Stueckle

Todd Stueckle, PhD

Adjunct Assistant Professor

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304-285-6098
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Positions

Adjunct Assistant Professor

Organization:
School of Medicine
Classification:
Adjunct Faculty

Publications

Publications 

  1. Stueckle TA, Jensen J, Coyle J, Derk R, Wagner A, Dinu CZ, Kornberg TG, Friend S, Agarwal S, Gupta R, Rojanasakul LW. In vitro inflammation and toxicity assessment of pre- and post-incinerated organomodified nanoclays to macrophages using high-throughput screening approaches. Submitted. 

 

  1. O’Connell RC, Dodd TM, Clingerman SM, Fluharty KL, Coyle J, Stueckle TA, Porter DW, Bowers L, Stefaniak AB, Knepp AK, Derk R, Wolfarth M, Mercer RR, Boots TE, Sriram K, and Hubbs AF. 2022. Developing a Solution for Nasal and Olfactory Transport of Nanoparticles. Toxicologic Pathology. doi.org/10.1177/01926233221089209. 

 

  1. Fraser K, Hubbs A, Yanamala N, Mercer RR, Stueckle TA, Jensen J, Eye T, Battelli L, Clingerman S, Fluharty K, Dodd T, Casuccio G, Bunker K, Lersch TL, Kashon M, Orandle M, Dahm MM, Schubauer-Berigan MK, Kodali V, Erdely A. Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model. Part. Fibre Toxicol. 2021. Doi: 10.1186/s12989-021-00440-z. 

 

  1. Goodrich JM, Calkins MM, Caban-Martinez AJ, Stueckle T, Grant C, Calafat AM, Nematollahi A, Jung AM, Graber JM, Jenkins T, Slitt AL, Dewald A, Beitel S, Littau S, Gulotta J, Wallentine D, Hughes J, Popp C, Burgess, JL. Per- and Polyfluoroalkyl Substances, Epigenetic Age, and DNA Methylation: A Cross-Sectional Study of Firefighters. Epigenetics 2021, Doi:10.2217/epi-2021-0225. 

 

  1. Coyle JP, Derk R, Kornberg T, Singh D, Jensen J, Friend S, Mercer RR, Stueckle TA, Demokritou P, Rojanasakul Y, Rojanasakul LW. Carbon Nanotube Filler Enhances Incinerated Thermoplastics-induced Cytotoxicity and Metabolic Disruption In Vitro. Part. Fibre Toxicol. 2020. 17:40. 

 

  1. Eldawud R, Wagner A, Dong C, Gupta N, Rojanasakul Y, O’Doherty G, Stueckle TA, Dinu CZ. Potential antitumor activity of digitoxin and user-designed analog administered to human lung cancer cells. BBA General Subjects. 2020. 1864(11):129683.  

 

  1. Lee EG, Kwon J, Cena L, Afshari A, Park HD, Casuccio G, Bunker K, Lersch T, Gall A, Pham H, Wagner A, Agarwal S, Dinu CZ, Gupta R, Friend S, Stueckle TA. Characterization of aerosolized particles from nanoclay-enabled composites during manipulation processes.  Environ. Sci. Nano. 2020, 7, 1539-1553. 

 

  1. Stueckle TA, White A, Wagner A, Gupta RK, Rojanasakul Y, Dinu CZ.  Impacts of Organomodified Nanoclays and Their Incinerated Byproducts on Bronchial Cell Monolayer Integrity. Chem. Res. Toxicol. 2019, 32(12): 2445-2458. 

 

  1. Kornberg TG, Stueckle TA, Coyle J, Derk R, Demokritou P, Rojanasakul LW. Iron oxide nanoparticle-induced neoplastic-like cellular transformation is reduced with protective amorphous silica coating. Chem. Res. Toxicol. 2019, 32, 12, 2382-2397. 

 

  1. Stueckle TA, Roberts J. 2019. Perspective on current alternatives in nanotoxicology research. Appl. In Vitro Toxicol. 5(3):111-113. Guest Editorial. 

 

  1. Siegrist KJ, Reynolds SH, Porter DW, Mercer, RR, Bauer A, Lowry D, Cena L, Kashon ML, Stueckle TA, Wiley J, Salisbury JL, Mastovich J, Bunker K, Sparrow M, Lupoi JS, Stefaniak AB, Tsuruoka S, Endo M, Terrones M, McCawley M, Sargent LM. 2019. Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells. Part. Fibre Toxicol. 16:36.  

 

  1. Farcas MT, Stefaniak A, Knepp A Bowers L, Mandler KW, Jackson SR, Stueckle TA, Sisler JD, Friend SA, Qi C, Hammond D, Kashon M, Thomas TA, Matheson J, Qian Y. 2019. Three-dimensional (3-D) printer emission-induced cell toxicity. Toxicology Letters. 317:1-12. 

 

  1. Kiratipaiboon C, Stueckle TA, Ghosh R, Rojanasakul LW, Chen YC, Dinu CZ, Rojanasakul Y. Acquisition of Cancer Stem Cell-like Properties in Human Small Airway Epithelial Cells after a Long-term Exposure to Carbon Nanomaterials. Environmental Science: Nano. 2019, Jul 1;6(7):2152-2170. 

 

  1. Wagner A, White A, Tang MC, Agarwal S, Stueckle TA, Rojanasakul Y, Gupta RK, Dinu CZ. 2018. Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity. Sci. Rep. 8(1):10709. 

 

  1. Stueckle TA, Davidson DC, Derk R, Kornberg TG, Battelli L, Friend S, Orandle MS, Wagner A, Dinu CZ, Sierros K, Agarwal S, Gupta RK, Rojanasakul Y, Porter DW, Wang L.  2018. Short-term pulmonary toxicity assessment of pre- and post-incinerated organomodified nanoclay in mice. ACS Nano. 12(3):2292-2310. 

 

  1. Eldawud R, Wagner A, Dong C, Stueckle TA, Rojansakul Y, Dinu CZ. 2018. Carbon nanotubes physicochemical properties influence the overall cellular behavior and fate. NanoImpact.9: 72-84. 

 

  1. Kornberg TG, Stueckle TA, Antonini JA, Rojanasakul Y, Castranova V, Yang Y, Wang L.  2017. Potential toxicity and underlying mechanisms associated with pulmonary exposure to iron oxide nanoparticles: conflicting literature and unclear risk. Nanomaterials (Basel). 7(10). pii: E307. 

 

  1. Wagner A, White A, Stueckle TA, Banerjee D, Sierros K, Rojanasakul Y, Agarwal, S, Gupta RK, Dinu CZ. 2017. Early assessment and correlations of nanoclay’s toxicity to their physical and chemical properties. ACS Applied Materials and Interfaces. 9(37):32323-32335. 

 

  1. Stueckle TA, Davidson DC, Derk R, Wang P, Friend S, Schwegler-Berry D, Zheng P, Wu N, Castranova V, Rojanasakul Y, Wang L. 2017. Effect of surface functionalizations of MWCNTs on neoplastic transformation potential in primary human lung epithelial cells. Nanotoxicology. 11(5):613-624. 

 

  1. Stueckle TA, Davidson DC, Derk R, Kornberg TG, Schwegler-Berry D, Pirela SV, Deloid G, Demokritou P, Luanpitpong S, Rojanasakul Y, Wang L. 2017. Evaluation of tumorigenic potential of CeO2 and Fe2O3 engineered nanoparticles by a human cell in vitro screening model. NanoImpact 6:39-54.  

 

  1. Wagner A, Eldawud R, White A, Agarwal S, Stueckle TA, Sierros K, Rojanasakul Y, Gupta RK, Dinu CZ. 2017. Toxicity evaluations of nanoclays and thermally degraded byproducts through spectroscopical and microscopical approaches. Biochim Biophys Acta 1861:3406-3415. 

 

  1. He X, Despreaux E, Stueckle TA, Chi A, Castranova V, Dinu CZ, Wang L, Rojanasakul Y.  2016. Role of mesothelin in carbon nanotube-induced carcinogenic transformation of human bronchial epithelial cells. Amer J Physiol Lung Cell Mole Physiol. 311:L538-49. 

 

  1. Stueckle TA, Sargent L, Rojanasakul Y, Wang L.  2016. Genotoxicity and carcinogenic potential of carbon nanomaterials, Chpt. 10.  In: Biomedical applications and toxicology of carbon nanomaterials.  Editors: Chunying Chen and Haifang Wang, Wiley-VCH Verlag GmbH & KGaA, Weinheim, Germany.  P. 265-330.  doi:10.1002/9783527692866.ch10 

 

  1. Davidson DC, Derk R, He X, Stueckle TA, Cohen J, Pirela SV, Demokritou P, Rojanasakul Y, Wang L.  2016. Direct stimulation of human fibroblasts by nCeO2 in vitro is attenuated with an amorphous silica coating.  Part Fibre Toxicol. 13:23. 

 

  1. Mishra A, Stueckle TA, Mercer RR, Derk R, Rojanasakul Y, Castranova V, Wang L.  2015.  Identification of TGF-Beta Receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis.  Am J Physiol Lung Cell Mol Physiol. 309: L281-33. 

 

  1. Chen D, Stueckle TA, Luanpitpong S, Lu Y, Rojanasakul Y, Wang L.  2015. Gene expression profile of human lung epithelial cells chronically exposed to single walled-carbon nanotubes.  Nanoscal Res Lett. 10:12. 

 

  1. Derk R, Davidson DC, Manke A, Stueckle TA, Rojanasakul Y, Wang L.  2015. Potential in vitro model for testing the effect of exposure to nanoparticles on the lung alveolar epithelial barrier.  Sens. Biosens Res 3:38-45. 

 

  1. Pongrakhannon V, Luanpitpong S, Stueckle TA, Wang L, Nimmannit U, Rojanasakul Y.  2015. Carbon nanotubes induce apoptosis resistance of human lung epithelial cells through FLICE-inhibitory protein. Toxicological Sciences. 143:499-511. 

 

  1. Lohcharoenkal W, Stueckle TA, Wang L, Dinu CZ, Liu Y, Castranova V, Rojanasakul Y.  2014.  Role of H-Ras/ERK signaling in carbon nanotube-induced neoplastic transformation of human mesothelial cells. Front. Physiol. 5:222.   

 

  1. Luanpitpong S, Wang L, Stueckle TA, Tse W, Chen YC, Rojanasakul Y.  2014.  Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis.  Oncotarget 5:3541-3554. 

 

  1. Manke A, Luanpitpong S, Dong C, Wang L, He X, Battelli L, Derk R, Stueckle TA, Porter D, Sager T, Gou H, Dinu CZ, Wu N, Mercer RR, Rojanasakul Y.  2014. Effect of fiber length on carbon nanotube-induced fibrogenesis.  Int J Mole Sci. Nanotoxicology and Lung Diseases. 15: 7444-61.   

 

  1. Stueckle TA, Eldawud R, Manivannan S, Elbaz H, Rojanasakul Y, Dinu CZ.  2014.  Real time analysis of the effects of toxic, therapeutic and sub-therapeutic concentrations of digitoxin on lung cancer cells.  Biosensors and Bioelectronics.  59: 192-199.   

 

  1. Stueckle TA, Pongrakhannon V, Wang HL, O’Doherty GA, Dinu CA, Chanvorachote P, Rojanasakul Y.  2014.  Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation. Biochem. Pharmacol. 88: 23-35.  

 

  1. Stueckle TA, Wang L, Mishra A, Derk R, Castranova V, Rojanasakul Y. 2014. Neoplastic-like transformation effect of single-walled and multiwalled carbon nanotubes compared to asbestos on human lung small airway epithelial cells. Nanotoxicology, 8: 485-507.  

 

  1. Lohcharoenkal W, Wang L, Stueckle TA, Dinu CZ, Liu Y, Castranova V, Rojanasakul Y.  2013.  Chronic exposure to carbon nanotubes induces invasion of human mesothelial cells through matrix metalloproteinase-2.  ACS Nano. 7:7711-7723. 

 

  1. Stueckle TA, Lu Y, Davis ME, Wang L, Jiang BH, Holaskova I, Schafer R, Barnette J, Rojanasakul Y.  2012. Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in lung epithelial cells. Toxicol. Appl. Pharm. 261: 204-216. 

 

  1. Elbaz H, Stueckle TA, Tse W, Rojanasakul Y, Dinu CZ.  2012.  Digitoxin and its analogs as novel cancer therapeutics.  Exp. Hematol. Onco. 1:4. 

 

  1. Elbaz H, Stueckle TA, Wang HYL, O’Doherty GA, Lowry DT, Sargent LM, Wang LM, Dinu CZ, Rojanasakul Y.  2012.  Digitoxin and synthetic analog inhibit cell viability in lung cancer cells.  Toxicol. Appl. Pharmacol. 258:51-60. 

 

  1. Wang HL, Xin W, Zhou M, Stueckle TA, Rojanasakul Y, O’Doherty GA.  2011.  Stereochemical survey of digitoxin monosaccharides: novel potential anticancer agents with enhanced apoptotic activity and growth inhibitory effect in non-small cell lung cancer cells.  ACS Medicinal Chemistry Letters. 2: 73-78. 

 

  1. Stueckle TA, Shock B, Foran CM.  2009.  Multiple stressor effects of methoprene, permethrin and salinity on limb regeneration and molting in the mud fiddler crab, Uca pugnax.  Environmental Toxicology and Chemistry.  28: 2348-2359. 

 

  1. Shock B, Foran CM, Stueckle TA.  2009.  Effects of salinity stress on Uca pugnax’s survival, metabolism, limb regeneration and ecdysis.  Journal of Crustacean Biology 29: 292-300. 

 

  1. Stueckle TA.  2008.  An evaluation of the non-target effects of mosquito control pesticides on Uca pugnax physiology, limb regeneration and molting processes.  Ph.D. Dissertation.  West Virginia University, Morgantown, WV. 

 

  1. Stueckle TA, Likens J, Foran CM.  2008.  Limb regeneration and molting processes under chronic methoprene exposure in the mud fiddler crab, Uca pugnax.  Comparative Biochemistry and Physiology C 147: 366-377. 

 

  1. Stueckle TA, Griffin K, Foran CM.  2008.  No acute toxicity of the mud fiddler crab, Uca pugnax, exposed to sediment-borne permethrin.  Environmental Toxicology.  23: 530-538. 

 

  1. Pineda J, Starczak V, Stueckle TA.  2006.  Timing of successful settlement: demonstration of a recruitment window in the barnacle Semibalanus balanoides.  Marine Ecology Progress Series 320, 233-237. 

About Todd Stueckle

Biographical Information 

Education 

PhD, West Virginia University, Morgantown, WV 2008 

MA, Boston University Marine Program, Woods Hole, MA, 2002 

BS, Western Washington University, Bellingham, WA, 1998 

 

Research Program 

Identifying key events and modes of action of inhaled toxicants, such as nanomaterials, metals, and organics, that lead to chronic disease in pulmonary and other organ systems.  

 

Research Interests 

As human society moves well into the 21st Century, a major player in new or replacement technologies are engineered nanomaterials and associated nanotechnologies. These human-made materials take on a particle form smaller than most viruses and are incorporated into a diverse number of applications. Human workers are exposed during synthesis, handling, use, manipulation, and disposal; however, we know very little about the health consequences to exposed workers.  

Our lab’s long-term objective is to understand how low dose, repeated exposures to inhaled toxicants initiates and promotes chronic disease development. First, we attempt to fully characterize differences in particles to understand how these physicochemical differences impact delivered/internal dose and toxicological responses. Second, we use a tiered and comparative testing approach by employing novel in vitro exposure and biological models along with animal studies to elucidate key events in disease development.  This approach helps define adverse responses to occupational hazards and helps inform risk assessment to protect workers’ health. 

The lab’s recent research program has expanded past single, homogeneous particle exposures into more complex, realistic exposures that attempt to address emerging technologies and issues in occupational health. Ongoing studies evaluate nanocomposite dust release, halogenated organics, and thermoplastic toxicities. Recent pilot efforts have started to study per- and polyfluorinated alkyl substances (PFAS) and firefighting foam toxicity and the potential for chronic disease development.  

 

Mentoring Style 

Our federal research laboratory located at CDC/NIOSH Morgantown is highly collaborative and is focused on a team effort to accomplish our goals. Students take an active part. They are expected to learn and show their ability to formulate a specific set of scientific questions, and then find and develop those techniques and expertise to answer those questions. Weekly meetings with students help develop critical thinking skills from hypothesis generation, statistics, writing, and presenting their research findings. I have greatly benefited from formally and informally mentoring 11 undergraduate, 10 graduate, and 3 post-doctoral students. I am a long-standing active member of the Society of Toxicology and the associated regional chapter which provides excellent networking opportunities for students to present their research and build their career.