David Rasicci, PhD

Assistant Professor, Department of Pathology, Anatomy & Laboratory Medicine

Organization:

West Virginia University School of Medicine

Department:

Pathology, Anatomy and Laboratory Medicine

Classification:

Faculty

• PhD, Pennsylvania State University, College of Medicine, 2022
• MS, Colorado State University, 2018
• BS, University of California, Santa Barbara, 2011

1. Bodt SML, Ge J, Ma W, Rasicci DV, et al. Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release. PNAS Nexus. Aug 2024;3(8):pgae279. https://doi.org/10.1093/pnasnexus/pgae279

2. Duno-Miranda S, Nelson SR, Rasicci DV, et al. Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state. J Gen Physiol. Jun 03 2024;156(6). https://doi.org/10.1085/jgp.202313522

3. Rasicci DV, Tolaymat O, Bolyard RJ, Dunmore CA, Zdilla MJ, Lambert HW. Geographical Impact of Human Gift Registries in West Virginia: A Model for Centralized Resources in Human Anatomy Education. Human Anatomy ed: Proceedings of the West Virginia Academy of the Sciences; 2023. https://doi.org/10.55632/pwvas.v95i1.1024

4. Rasicci DV, Ge J, Milburn GN, et al. Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure. Am J Physiol Heart Circ Physiol. Feb 01 2023;324(2):H198-H209. https://doi.org/10.1152/ajpheart.00272.2022

5. Doran MH, Rynkiewicz MJ, Rasicci DV, et al. Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. J Gen Physiol. Mar 06 2023;155(3). https://doi.org/10.1085/jgp.202213267

6. Doran MH, Rynkiewicz MJ, Pavadai E, Rasicci DV, et al. Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. J Gen Physiol. Feb 06 2023;155(2). https://doi.org/10.1085/jgp.202213274

7. Rasicci DV, Tiwari P, Bodt SML, et al. Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin. Elife. Nov 24 2022;11. https://doi.org/10.7554/eLife.77415

8. Touma AM, Tang W, Rasicci DV, et al. Nanosurfer Assay Dissects β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions. Biophys J. May 18 2022; https://doi.org/10.1016/j.bpj.2022.05.013

9. Mahmud Z, Tikunova S, Belevych N, Rasicci DV, et al. Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction. Front Physiol. 2022;13:892979. https://doi.org/10.3389/fphys.2022.892979

10. Rasicci DV, Kirkland O, Moonschi FH, et al. Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin. J Gen Physiol. Jul 2021;153(7) https://doi.org/10.1085/jgp.202012811