Contact
Positions
Assistant Professor
- Organization:
- West Virginia University School of Medicine
- Department:
- Microbiology, Immunology & Cell Biology
- Classification:
- Faculty
Member
- Organization:
- West Virginia University WVU Cancer Institute
- Department:
- WVU Cancer Institute Research Programs
- Classification:
- Faculty
Education
- PhD, East Carolina University, Brody School of Medicine, 2015
Publications
Select Publications
1. Busada JT, Ramamoorthy S, Cain, DW, Xu X, Cook DN, Cidlowski JA. (2019) Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation. J Clin Invest. 129(3): 1345-1358. 2019.
2. Busada JT*, Peterson KN, Khadka S, Xu X, Oakley RH, Cook DN, Cidlowski JA. Glucocorticoids and Androgens Protect from Gastric Metaplasia by Suppressing Group 2 Innate Lymphoid Cell Activation. Gastroenterology. 161(2):637-652. 2021.
*Corresponding author
3. Busada JT*, Kadka S, Peterson KN, Druffner SR, Stumpo DJ, Zhou L, Cidlowski JA, Blackshear PJ. Tristetraprolin prevents gastric metaplasia in mice by suppressing pathogenic inflammation. Cell and Mol Gastro Hepatol. 12(5):1831-1845. 2021.
*Corresponding author
4. Khadka S, Druffner SR, Duncan BC, Busada JT. Glucocorticoid regulation of cancer development and progression. Front Endocrinol (Lausanne). 2023;14:1161768. Epub 2023/05/05. doi:0.3389/fendo.2023.1161768. 2023.
5. Druffner SR, Venkateshwaraprabu S, Khadka S, Duncan BC, Morris MT, Sen-Kilic E, Damron FH, Liechti GW, Busada JT. Comparison of gastric inflammation and metaplasia induced by Helicobacter pylori or Helicobacter felis colonization in mice. Microbiol Spectr. 12(6):e0001524. Epub 20240429. doi: 10.1128/spectrum.00015-24. 2024.
6. Khadka S, Dziadowicz SA, Xu X, Wang L, Hu G, Carrero JA, DiPaolo RJ, Busada JT. Endogenous glucocorticoids are required for normal macrophage activation and gastric Helicobacter pylori immunity. Am J Physiol Gastrointest Liver Physiol. Epub 20240723. doi: 10.1152/ajpgi.00114.2024. 2024.
7. Morris MT, Duncan BD, Piazuelo MB, Olfert IM, Xu X, Hussain S, Peek RM, Busada JT. Chronic cigarette smoke exposure masks pathological features of Helicobacter pylori infection while promoting tumor initiation. Cancer Prevention Research. doi: 10.1158/1940-6207.CAPR-24-0378. 2025.
Research Program
WVU Cancer Institute Research Programs
Research Interests
Gastric cancer is the 5th most common cancer in the world. Most cases of gastric cancer are associated with infection by the bacteria Helicobacter pylori. The infection causes massive gastric inflammation, which damages the stomach, and promotes gastric carcinogenesis. The factors that regulate gastric inflammation and how the inflammatory microenvironment promotes cancer development are unclear. Our goal is to understand how inflammation promotes gastric cancer development to facilitate the discovery of new gastric cancer diagnostics and treatments. Visit the lab website for more information what the lab is doing and our specific research projects.