Jonathan Busada , PhD

Assistant Professor

Organization:

West Virginia University School of Medicine

Department:

Microbiology, Immunology & Cell Biology

Classification:

Faculty

Member

Organization:

West Virginia University WVU Cancer Institute

Department:

WVU Cancer Institute Research Programs

Classification:

Faculty

• PhD, East Carolina University, Brody School of Medicine, 2015

Recent Publications: 

*Corresponding author 

Khadka S, Druffner SR, Duncan BC, Busada JT. Glucocorticoid regulation of cancer development and progression. Front Endocrinol (Lausanne). 2023;14:1161768. Epub 2023/05/05. doi: 10.3389/fendo.2023.1161768.

Busada JT*, Peterson KN, Khadka S, Xu X, Oakley RH, Cook DN, Cidlowski JA*. Glucocorticoids and Androgens Protect from Gastric Metaplasia by Suppressing Group 2 Innate Lymphoid Cell Activation. Gastroenterology. 161(2):637-652. 2021.

*Co-corresponding author

Kirsanova O, Renegar RH, Busada JT, Serra ND, Harrington EV, Johnson TA, Geyer CB. The rapamycin analog Everolimus reversibly impairs male germ cell differentiation and fertility in the mouse. Biol Reprod. 103(5):1132-1143. 2020.

Chung Nien Chin S, O'Connor L, Scurr M, Busada JT, Graham A, Alipour Talesh G, Tran C, Sarkar S, Minamoto M, Giraud A, Cidlowski J, Sutton P, and Menheniott T. Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer. Am J Physiol Gastrointest Liver Physiol. 319(2): G175-188. 2020.

Diaz-Jimenez DO, Petrillo MG, Busada JT, Hermosa MA, Cidlowski JA. Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4. J Biol Chem. 295(10): 3213-3227. 2020.

Busada JT, Ramamoorthy S, Cain, DW, Xu X, Cook DN, Cidlowski JA. (2019) Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation. J Clin Invest. 129(3): 1345-1358. 2019.

Oakley RH, Ramamoorthy S, Foley JF, Busada JT, Lu NZ, Cidlowski JA. (2018) Glucocorticoid receptor isoform-specific regulation of development, circadian rhythm, and inflammation in mice. FASEB J. 32(10):5258-5271. 2018.

Busada JT and Cidlowski JA. Mechanisms of glucocorticoid action during development. Curr Top in Dev Biol. 125:147-170. 2017.

 

WVU Cancer Institute Research Programs

Gastric cancer is the 5th most common cancer in the world. Most cases of gastric cancer are associated with infection by the bacteria Helicobacter pylori. The infection causes massive gastric inflammation, which damages the stomach, and promotes gastric carcinogenesis. The factors that regulate gastric inflammation and how the inflammatory microenvironment promotes cancer development are unclear. Our goal is to understand how inflammation promotes gastric cancer development to facilitate the discovery of new gastric cancer diagnostics and treatments. Visit the lab website for more information what the lab is doing and our specific research projects.