Evan DeVallance

Research Assistant Professor

Organization:

West Virginia University School of Medicine

Department:

Physiology, Pharmacology & Toxicology

Classification:

Faculty

Graduate Program Affiliations: Cellular and Integrative Physiology

Reactive oxygen and nitrogen species are generated by numerous salutary and pathobiological processes. They can produce a number of cellular responses triggered by tightly controlled redox signaling mechanisms, via modifications of reactive cysteines. However, there is a significant gap in knowledge regarding how redox signaling regulations chromatin structure and epigenetics. The focus of my laboratory is to understand how specific triggers and sources of oxidants lead to redox-mediated changes in cellular epigenetics. This basic cellular process is likely to function in most cells while specific pathways may provide novel therapeutic targets in disease states.

AHA 23CDA1038976

U54GM104942

Projects

1.Uncovering A novel redox-mediated epigenetic pathway in the aging vasculature.

2.Defining a redox-mediated epigenetic priming of vascular inflammation.