Md Shahrier Amin, MD, PhD

Assistant Professor

Organization:

West Virginia University School of Medicine

Department:

Pathology, Anatomy and Laboratory Medicine

Classification:

Faculty

• MBBS, Dhaka Medical College, Dhaka, Bangladesh
• PhD, University of Ottawa, ON, Canada
• AP, University of Ottawa, 2013

Selected Publications:

• Kang J, Materu-Borras M, Monroe HL, Sen-Kilic E, Miller SJ, Dublin SR, Huckaby AB, Yang E, Pyles GM, Nunley MA, Chapman JA, Amin MS, Damron FH, Barbier M. Monoclonal antibodies against lipopolysaccharide protect against Pseudomonas aeruginosa challenge in mice. Front Cell Infect Microbiol,  13:1191806. PMID: 37424774; PMCID: PMC10326049, 2023.
• Lee KS, Wong TY, Miller OA, Cooper M, Rader NA, Amin MS, Winters M, Martinez I, Barbier M, Bevere JR, Ernst RK, Dicks MD, Biswas S, Damron FH. Intranasal VLP-RBD vaccine adjuvanted with BECC 470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice. Vaccine, 28;S0264-410X(23)00783-1, PMID: 37407405; PMCID: PMC10300285; DOI: 10.1016/j.vaccine.2023.06.080; 2023.
• Fakadej T, Hathaway QA, Balar AB, Amin MS, Lakhani DA, Kim C. Eosinophilic Myocarditis: Case report and brief review of the literature. Radiology Case Reports, 18:1, 306-311, 2023. PMID: 36388617.
• Balar A B, Mallicoat TA, Vos JA, Amin MS, Lakhani DA, Kim C. Aortic root abscess from Enterococcus faecalis infective endocarditis: Case report and brief review of the literature. Radiology Case Report, 17(11), 4193-4198, 2022. PMID: 36105831.
• Gross A, Amin MS, Jelic T. Liesegang rings in the setting of end-stage renal disease. Int J Urol Case Reports, IJUCR-2022-0009, 2022. PMID: 36341183.
• Lee KS, Wong TY, Russ BP, Hospool AM, Miller OA, Rader NA, Givi J, Winters MT, Wong ZA, Cyphert HA, Denvir J, Stoilov P, Barbier M, Amin MS, Martinez I, Bevere JR, Damron FH. SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice. PLOS ONE, 17(8): e0273430, 2022. PMID: 36037222.
• Garrison A, Amin MS, Williams J. Malignant mesothelioma of the tunica vaginalis, ASCP case reports, June 2022.
• Saleem M, Balla S, Amin MS, Farid S, Caccamo M, Sokos G, Bianco CM. Hereditary apolipoprotein A-I–associated cardiac amyloidosis: Importance of endomyocardial biopsy when suspicion remains high. JACC, 3(7), 1032-1037, 2021.
• Noorbakhsh S, Boner E, Amin MS. Burn Injury: Pathophysiology, Classification, and Treatment, Academic Pathology, 28;8:23742895211057239, PMID: 34869832; PubMed Central PMCID: PMC8637691, 2021.
• Esprit DH, Amin MS, Koratala A. Uncommon things to note about a common cause of nephrotic syndrome. Clin Case Reports, July, 2018, 1-2.
• Wright TC, Wyles CC, Amin MS, Jenkins SM, Day PL, Murray DL, Trousdale RT, Edwards WD, Maleszewski JJ. Myocardial Cobalt Levels Are Elevated in the Setting of Total Hip Arthroplasty. The Journal of Bone & Joint Surgery, June, 2017, 15;99(22):e118.
• Sethi S, Dasari S, Amin MS, Vrana JA, Theis JD, Alexander MP, Kurtin PJ. Clinical, biopsy, and mass spectrometry findings of renal gelsolin amyloidosis. Kidney International, January, 2017, 91(4):964-971.
• Amin MS, Dasari S, Kurtin P, Vrana J, Theis J, Grogg K, Nasr SH, Fervenza FC, Leung N, Sethi S. Clinical features, renal biopsy and mass spectrometry findings of apolipoprotein A-IV associated renal amyloidosis. Kidney International, 2016: 90(3)658-664.
• Weberpals JI, Amin MS, Chen BE, Tu D, Spaans J, Squire JA, Eisenhauer EA, Virk S, Ma D, Duciaume M, Hoskins P, Lebrun D. First application of the Automated Quantitative Analysis (AQUA) technique to quantify PTEN protein expression in ovarian cancer: a correlative study of NCIC CTG OV. Gynecologic Oncology, 140(3): 486-493, 2016.
• Al-Hijji M, Park JY, El Sabbagh A, Amin MS, Maleszewski J, Borgeson DD. The forgotten valve: isolated severe tricuspid valve stenosis. Circulation, 132(7): e123:5, 2015.
• Baldwin RM, Haghandish N, Daneshmand M, Amin MS, Paris G, Falls TJ, Bell JC, Islam S, Cote J. Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression. Oncotarget, 6(5): 3013-3032, 2015.
• Khandelwal A, Virmani V, Amin MS, George U, Khandelwal K, Gorsi U. Radiology–pathology conference: malignant solitary fibrous tumor of the seminal vesicle. Clinical Imaging, 2012.
• Van Huysse J, Amin MS, Yang B, Leenen FH. Salt-induced hypertension in a mouse model of Liddle’s syndrome is mediated by epithelial sodium channels in the brain. Hypertension. 60(3):691-696, 2012.
• Hilton JF, Amin MS, Daneshmand M, Weberpals JI, Lorimer I, Islam S, Mallick R, Kanji F, Hopkins S, Verma S. BRCA1 protein levels and PI3KA mutations as predictive biomarkers for response to neoadjuvant chemotherapy in locally advanced breast cancer: An exploratory analysis. Oncology Letters, 4(1), 141-145, 2012.
• Mai KT, Belanger EC, Djordjevic B, Amin MS, Nguyen B. Urinary bladder sinuses - a novel morphological lesion with clinical and pathological significance. Applied immuno-histochemistry and molecular morphology, 20(5), 494-500, 2012.
• Paget JA, Restall IJ, Daneshmand M, Mersereau JA, Simard M, Parolin DAE, Lavictoire SJ, Amin MS, Islam S, Lorimer IAJ. Repression of cancer cell senescence by PKCi. Oncogene, 2(31):3584-3596, 2012.
• Amin MS, Senterman M, Islam S. Co-expression and cellular localization of p16 (INK 4a) and Mib1 (Ki-67) help in differentiating high grade squamous intraepithelial lesions from immature squamous metaplasia of the uterine cervix. Canadian Journal of Pathology, 3(4):22-27, 2011.
• Amin MS, Reza E, El-Shahat E, Wang HW, Tesson F, Leenen FH. Enhanced expression of epithelial sodium channels in the renal medulla of Dahl S rats. Canadian Journal of Physiology and Pharmacology, 89(3):159-168, 2011.
• Weberpals JI, Tu D, Squire JA, Amin MS, Islam S, Pelletier LB, O'Brien AM, Hoskins PJ, Eisenhauer EA. Breast cancer 1 (BRCA1) protein expression as a prognostic marker in sporadic epithelial ovarian carcinoma: an NCIC CTG OV.16 correlative study. Annals of Oncology, 22(11):2403-2410, 2011.
• Wang HW, Amin MS, El-Shahat E, Huang BS, Tuana BS, Leenen FH. Effects of central sodium on epithelial sodium channels in rat brain. American Journal of Physiology and Pharmacology: Regulatory, Integrative and Comparative Physiology, 299(1):R222-233, 2010.
• Amin MS, Reza E, Wang H, Leenen FH. Sodium transport in the choroid plexus and salt-sensitive hypertension. Hypertension,54(4):860-867, 2009.
• Huang BS, Amin MS, Leenen FH. The central role of the brain in salt-sensitive hypertension. Current opinion in cardiology,21:295-304, 2006.
• Amin MS, Wang HW, Reza E, Whitman SC, Tuana BS, Leenen FH. Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology; 289:R1787-R1797, 2005.

Link to PubMed for full list of publications: https://www.ncbi.nlm.nih.gov/myncbi/1lyton59nCD/bibliography/public/

2015 Society for Cardiovascular Pathology Young Investigator Award Competition (runner-up).
2012 Dr. Virbala Acharya Award for best platform presentation (won).
2010 Dr. Nadia Mikhael Award for best platform presentation (won).
2009 Best Poster Award at Pathology Annual Research Day (won).
2007 Ontario Graduate Scholarship in Science and Technology (2007-2009).
2006 Honorable mention for Poster at the CIHR National Poster Competition (runner-up).
2006 Honorable mention for oral presentation at University of Ottawa Heart Institute Annual Research Day (runner-up).
2006 Travel award from National Research Forum for Young Investigators in Circulatory and Respiratory Health.
2005 University of Ottawa Excellence Scholarship (2005-2007).
2005 Pfizer / Canadian Institutes of Health Research (CIHR) / Canadian Hypertension Society (CHS) Doctoral Research Award (2005-2007).
2004 Travel award from Canadian Hypertension Society.

Book chapters, Thesis

• Amin MS, Bonsib SM. “Non-neoplastic diseases of the kidney.” In “Urologic Surgical Pathology” by David B. Bostwick, 4th edition.
• Leenen FH, Amin MS, Stewart AFR, and Tesson F. Genetic basis of salt-sensitive hypertension in humans. Chapter 16 in Genes and Cardiovascular Functionedited by Ostadal B, Nagano M, Dhalla NS, 1st Edition, 2011, Springer Science Business Media.
• Amin MS. Epithelial sodium channels in the brain: effect of high salt diet on their expression. PhD Thesis, 2011. https://www.ruor.uottawa.ca/fr/handle/10393/20074

• Fellowship - Renal and transplant pathology, Mayo Clinic
• Fellowship – Cardiovascular pathology, Mayo Clinic
• Residency – Anatomic Pathology, University of Ottawa

Medical Specialties

• Autopsy
• Cardiovascular Pathology
• Pathology
• Renal Pathology
• Transplant Pathology

Board Certifications

• Anatomic Pathology, American Board of Pathology

Special Training

• Residency, Anatomical Pathology
  University of Ottawa, ON, Canada
• Fellowship, Renal Pathology
  Mayo Clinic, Rochester, MN
• Fellowship, Cardiovascular Pathology
  Mayo Clinic, Rochester, MN

Research Interests:

• Renal and Cardiac Amyloidosis
• Implementing artificial intelligence and telepathology for diagnostic services in resource poor settings
• Solid organ transplantation
• Long term effects of novel drugs and farming practices on human health
• Neural regulation of cardiovascular and renal function
• Salt sensitive hypertension
• Fluid and ion transport in the choroid plexus