- PhD, University of Louvain, Belgium
Nel J, Desmet CM, Driesschaert B, Saulnier P, Lemaire L, Gallez B. Preparation and evaluation of trityl-loaded lipid nanocapsules as oxygen sensors for electron paramagnetic resonance oximetry. Int J Pharm. 2019;554:87-92.
Poncelet M, Driesschaert B, Tseytlin O, Tseytlin M, Eubank TD, Khramtsov VV.Dextran-conjugated tetrathiatriarylmethyl radicals as biocompatible spin probes for EPR spectroscopy and imaging.Bioorg Med Chem Lett. 2019;29(14):1756-1760.
Driesschaert B, Khramtsov, VV. Synthesizing paramagnetic probe useful for monitoring tumor microenvironment, comprises trityl moiety, alkyne composition and solvent and mixing trityl moiety and alkyne composition in presence of solvent to create reaction mixture. 2019, WO2019018655-A1.
Sanzhaeva U, Xu X, GuggilapuP, Tseytlin M, Khramtsov VV*, Driesschaert B. Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase, Angew. Chem. Int. Ed. 2018;57(36):11701-11705.
Video abstract: https://vimeo.com/292981331Gorodetskii AA, Eubank TD,
Driesschaert B, Poncelet M, Ellis E, Khramtsov VV, Bobko AA.Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors, J. Mag. Reson. 2018; 297:42-50.
Scheinok S, Leveque P, Sonveaux P, Driesschaert B, Gallez B. Comparison of different methods for measuring the superoxide radical by EPR spectroscopy in buffer, cell lysates and cells.. 2018; 52(10):1182-1196.
Bobko AA, Eubank TD, Driesschaert B, Khramtsov VV. In Vivo Assessment of pH, pO2, Redox Status and Concentrations of Phosphate and Glutathione in Tumor Microenvironment by Electron Paramagnetic Resonance Spectroscopy, J. Vis. Exp.2018; 133, doi:10.3791/56624.
Driesschaert B, Bobko AA, Khramtsov VV. Triarylmethyl based biradical as a superoxide probe, Free Rad. Res. 2018; 52(3):373-379.
Marchand V, Levêque P, Driesschaert B, Marchand-Brynaert J, Gallez B. In vivo EPR extracellular pH-metryin tumors using a triphosphonatedtrityl radical. Magn. Reson. Med. 2017;77(6):2438-2443.
Driesschaert B, Bobko AA, Khramtsov VV, Zweier JL. Nitro-Triarylmethyl Radical as DualOxygen and Superoxide Probe.Cell. Biochem. Biophys. 2017;75(2):241-246.
Khramtsov VV, Bobko AA, Tseytlin M, Driesschaert B. Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment. Anal. Chem. 2017;89(9):4758-4771. Featured the journal cover picture
Bobko AA, Eubank TD, Driesschaert B, Dhimitruka I, Evans J, Mohammad R, Tchekneva EE, Dikov MM, Khramtsov VV. Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression. Sci. Rep. 2017;7:41233.
About Benoit Driesschaert
Dr. Driesschaert earned his Ph.D. from the Université Catholique de Louvain (UCL) Belgium. In 2014, he moved to the Ohio State University to carry out his postdoctoral research. In 2017 Dr. Driesschaert was awarded an NIH K99/R00 Pathway to independence from the NIBIB to launch his independent research programs. He is now an Assistant Professor at the Department of Pharmaceutical Sciences.
- Development of advanced contrast agents for magnetic resonance based imaging (EPR/NMR)
- Nanoformulation and drug delivery system
- Development of fluorescence probes to image reactive oxygen species (ROS)
- Development of polarizing agents for NMR and MRI
Description of Research
Research in my laboratory is focused on the development and applications of probes for medical imaging. Specifically, the lab is developing advanced paramagnetic probes that enable in vivo measurement of physiologically relevant parameters, such as enzyme activities, oxygen concentration or pH non-invasively using magnetic resonance based techniques (EPR/NMR). The development of nanoparticles loaded with an imaging probe and/or a therapeutic agent for diagnostic and/or therapeutic purpose is also an important part of our work. The laboratory develop fluorescence probes that allows for in vivo imaging of reactive oxygen species (ROS). Finaly, we desing and synthesize polarizing agents that allow to enhance the sensititivy of NMR and MRI techniques.