Nicole Bryan , MD, PhD

Associate Professor

Organization:

West Virginia University School of Medicine

Department:

Medicine

Classification:

Faculty

• MD, West Virginia University School of Medicine, 2011

• Othumpangat S, Bryan NB, Beezhold DH, Noti JD.  2017.  Upregulation of miRNA-4776 in influenza virus infected bronchial epithelial cells is associated with downregulation of NFKBIB and increased viral survival.  Viruses.  9(5).

• Bryan, NB., Dorfleutner, A, Kramer, SJ, Yun, C, Rojanasakul, Y, Stehlik, C.  2010.  Differential splicing of the apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) regulates inflammasomes.  Journal of Inflammation.  7(23).

• Bryan, NB, Dorfleutner, A., Rojanasakul, Y, Stehlik, C.  2009.  Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain.  Journal of Immunology.  182(5): 3173-82.  Featured Article.

• Dorfleutner, A., Bryan, NB, Talbott, SJ, Funya, KN, Rellick, SL, Reed, JC, Shi, X, Rojanasakul, Y., Flynn, DC, and Stehlik, C. 2007 Cellular PYRIN domain-only protein is a candidate regulator of inflammasome activation. Infect. Immun. 75 (3); 1484-1492.
   
• Khare, S, Dorfleutner, A, Bryan, NB, Yun, C., Radian, A.D., de Almeida, L., Rojanasakul, Y, Stehlik, C.  2012.  An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages.  Immunity.  36 (3): 464-476.

• Dorfleutner, A, Talbott, SJ, Bryan, NB, Funya, KN, Relllick, SL,  Reed, JC, Shi, X, Flynn, DC, Rojanasakul, Y and Stehlik, C. 2007. A shope fibroma virus PYRIN-only protein modulates the host immune response. Virus Genes.  35 (3): 685-694

WVU Clinical Science and Translation Institute Research Scholar                  2016 - Present

Patient Care Award West Virginia University                                                          2014

Van Liere Research Day 1^st Place Poster Award West Virginia University          2007, 2008, 2009

Hyma Award for Excellence in Chemistry West Virginia Wesleyan College        2001, 2002, 2003

Mason-Crickard Academic Scholarship West Virginia Wesleyan College           1999-2003

Nicole Bryan, MD, PhD is currently an Assistant Professor of Medicine in the section of Infectious Diseases at West Virginia University (WVU).  She obtained both her MD degree as well as her PhD degree in Cancer Cell Biology from West Virginia University.  She subsequently completed her residency in Internal Medicine and Fellowship in Infectious Diseases at West Virginia University.  Her research portfolio includes experience in both basic sciences as well as clinical research.  Her research focus during her PhD training focused on elucidating cellular regulatory mechanisms controlling the processing and release of the potent pro-inflammatory cytokine IL-1β.  During her Infectious Diseases fellowship training, she studied the impact of microRNA on the bronchial epithelial response to influenza infection in collaboration with researchers from NIOSH.  That work was recently nominated by NIOSH for the prestigious CDC Charles Shepard Award in the Laboratory Science category.  Regarding her clinical research, she is exploring the impact that intimate partner violence has on infectious disease transmission as well as treatment outcomes.  She is also studying the frequency of Hepatitis C screening during pregnancy, and clinical outcomes of mothers and infants after active infection has been identified.  Her current work is supported by funding from the CTSI Scholar program.  She is also actively involved in teaching and mentoring individuals at various stages in their medical training including medical students, residents, and fellows.  In addition, she maintains a very active clinical practice caring for patients with infectious diseases in the inpatient and outpatient settings.           

Special Training

• Fellowship, Infectious Diseases
  West Virginia University Hospital, 2016
• Residency, Internal Medicine
  West Virginia University, 2014