Epel B, Sundramoorthy SV, Krzykawska-Serda M, Maggio MC, Tseytlin M, Eaton GR, Eaton SS, Rosen GM, J PYK, Halpern HJ. "Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance." J Magn Reson. 2017;276:31-6. doi: 10.1016/j.jmr.2016.12.015. PubMed PMID: 28092786; PMCID: PMC5336491.
Tseytlin M. "Concept of Phase Cycling in Pulsed Magnetic Resonance Using Sinusoidal Magnetic Field Modulation." Z Phys Chem. 2017;231(3):689-703. doi: 10.1515/zpch-2016-0843. PubMed PMID: WOS:000393583200019, NIHMSID: NIHMS863707.
Tseytlin M. "Full Cycle Rapid Scan EPR Deconvolution Algorithm." J Magn Res. 2017; 281 (272)
Khramtsov VV, Bobko AA, Tseytlin M, Driesschaert B. "Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment." Anal Chem. 2017;89(9):4758-71. doi: 10.1021/acs.analchem.6b03796. PubMed PMID: 28363027.
Moser J, Lips K, Tseytlin M, Eaton GR, Eaton SS, Schnegg A. "Using rapid-scan EPR to improve the detection limit of quantitative EPR by more than one order of magnitude." J Magn Reson. 2017;281:17-25. doi: 10.1016/j.jmr.2017.04.003. PubMed PMID: 28500917.
Tseytlin M, Epel B, Sundramoorthy S, Tipikin D, Halpern HJ. "Decoupling of excitation and receive coils in pulsed magnetic resonance using sinusoidal magnetic field modulation." J Magn Reson. 2016;272:91-9. doi: 10.1016/j.jmr.2016.09.004. PubMed PMID: 27673275; PMCID: PMC5071169.
Biller JR, Mitchell DG, Tseytlin M, Elajaili H, Rinard GA, Quine RW, Eaton SS, Eaton GR. "Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo." J Vis Exp. 2016(115). doi: 10.3791/54068. PubMed PMID: 27768025; PMCID: PMC5092072.
Z. Yu, M. Tseytlin, S.S. Eaton, and G. R. Eaton, "Multiharmonic Electron Paramagnetic Resonance for Extended Samples with both Narrow and Broad Lines", J. Magn. Reson., 254, pp 86-92
Elajaili HB, Biller JR, Tseitlin M, Dhimitruka I, Khramtsov VV, Eaton SS, Eaton GR. "Electron spin relaxation times and rapid scan EPR imaging of pH-sensitive amino-substituted trityl radicals". Magn Reson Chem. 2015 Apr;53(4):280-4. doi: 10.1002/mrc.4193. Epub 2014 Dec 12. PMID: 25504559
Biller JR, Tseitlin M, Mitchell DG, Yu Z, Buchanan LA, Elajaili H, Rosen GM, Kao JP, Eaton SS, Eaton GR. "Improved sensitivity for imaging spin trapped hydroxyl radical at 250 MHz." Chemphyschem. 2015 Feb 23;16(3):528-31. doi: 10.1002/cphc.201402835. Epub 2014 Dec 8. PMID: 25488257
Tseitlin M, Yu Z, Quine RW, Rinard GA, Eaton SS, Eaton GR. "Digitally generated excitation and near-baseband quadrature detection of rapid scan EPR signals". J Magn Reson. 2014 Oct 30;249C:126-134. doi: 10.1016/j.jmr.2014.10.011. [Epub ahead of print] PMID: 25462956
Yu Z, Quine RW, Rinard GA, Tseitlin M, Elajaili H, Kathirvelu V, Clouston LJ, Boratyński PJ, Rajca A, Stein R, Mchaourab H, Eaton SS, Eaton GR. "Rapid-scan EPR of immobilized nitroxides". J Magn Reson. 2014 Oct;247:67-71. doi: 10.1016/j.jmr.2014.08.008. Epub 2014 Aug 30. PMID: 25240151
Tseitlin M, Biller JR, Elajaili H, Khramtsov VV, Dhimitruka I, Eaton GR, Eaton SS. "New spectral-spatial imaging algorithm for full EPR spectra of multiline nitroxides and pH sensitive trityl radicals". J Magn Reson. 2014 Aug;245:150-5. doi: 10.1016/j.jmr.2014.05.013. Epub 2014 Jun 17. PMID: 25058914 Free PMC Article
Biomedical Imaging and Bioengineering
Development of novel bio-imaging methodologies, including theory, hardware and software.
The focus of our lab has been mostly on the development of novel electron paramagnetic resonance (EPR) imaging techniques. An alternatively used name is electron spin resonance (ESR). EPR is in many aspects similar to a better known nuclear magnetic resonance (NMR) modality. The same quantum mechanics laws govern both nuclear and electron spins. EPR is applied to solve medical and biological problems to a much less extent compared to NMR, and especially to its imaging modality magnetic resonance imaging (MRI). The major reason has been that protons (possess nuclear spin, S=1/2) in water are abundant in living organisms. Biomedical EPR requires the development of bio-compatible molecular probes that have to be injected or implanted into the biological object under investigation. Such probes have been developed worldwide. Our WVU collaborators Drs. Khramtsov, Bobko and Driesschaert are pioneers in the field of EPR probes synthesis. The major goal of our lab is to develop instrumentation and data processing methods that enable reliable extraction of functional information, e.g. oxygen concentration, within a limited experimental time. Compared to measurement of inanimate objects, animals and people cannot be held for a long time immobilized in the magnet. Imaging experiment lasts from 3 to 20 minutes. During this time, thousands of EPR spectra have to be measured to post-processed to form an image.
Students help winding wire around a coil that will be used in the EPR spectrometer.
A student is tuning EPR system before measurement.