Aaron Erdely

Professor

Organization:

West Virginia University School of Medicine

Department:

Physiology, Pharmacology & Toxicology

Classification:

Adjunct Faculty

• PhD, West Virginia University, 2002

Full list of Publications: Erdely A - Search Results - PubMed (nih.gov)

Recent Publications:

1.     Wright S, Cassee FR, Erdely A, Campen MJ [2024]. Micro- and nanoplastics concepts for particle and fibre toxicologists. Part Fibre Toxicol. Apr 2;21(1):18.

2.     Zeidler-Erdely PC, Kodali V, Falcone LM, Mercer R, Leonard SS, Stefaniak AB, Grose L, Salmen R, Trainor-DeArmitt T, Battelli LA, McKinney W, Stone S, Meighan TG, Betler E, Friend S, Hobbie KR, Service S, Kashon M, Antonini JM, Erdely A [2024]. Absence of lung tumor promotion with reduced tumor size in mice after inhalation of copper welding fumes. Carcinogenesis. Jul 24 doi: 10.1093/carcin/bgae048.

3.     Young TL, Scieszka D, Begay JG, Lucas SN, Herbert G, Zychowski K, Hunter R, Salazar R, Ottens AK, Erdely A, Gu H, Campen MJ [2023]. Aging influence on pulmonary and systemic inflammation and neural metabolomics arising from pulmonary multi-walled carbon nanotube exposure in apolipoprotein E-deficient and C57BL/6 female mice. Inhal Toxicol. Mar-Apr;35(3-4):86-100. Epub 2022 Jan 17.

4.     Kodali V, Roberts JR, Glassford E, Gill R, Friend S, Dunn KL, Erdely A [2022]. Understanding toxicity associated with boron nitride nanotubes: Review of toxicity studies, exposure assessment at manufacturing facilities, and read-across. J Mater Res. Oct 31;37(24):4620-4638.

5.     Kodali V, Kim KS, Roberts JR, Bowers L, Wolfarth MG, Hubczak J, Xin X, Eye T, Friend S, Stefaniak AB, Leonard SS, Jakubinek M, Erdely A [2022]. Influence of impurities from manufacturing process on the toxicity profile of boron nitride nanotubes. Small Dec;18(52):e2203259.

6.     Mostovenko E, Canal CG, Cho M, Sharma K, Erdely A, Campen MJ, Ottens AK [2022]. Indirect mediators of systemic health outcomes following nanoparticle inhalation exposure. Pharmacol Ther. Jul;235:108120.

7.     Fraser K, Hubbs A, Yanamala N, Mercer RR, Stueckle TA, Jensen J, Eye T, Battelli L, Clingerman S, Fluharty K, Dodd T, Casuccio G, Bunker K, Lersch TL, Kashon ML, Orandle M, Dahm MM, Schubauer-Berigan MK, Kodali V, Erdely A [2021]. Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model. Part Fibre Toxicol, Dec 20;18(1):47.

8.     Fraser K, Kodali V, Yanamala N, Birch ME, Cena L, Casuccio G, Bunker K, Lersch TL, Evans DE, Stefaniak A, Hammer MA, Kashon ML, Boots T, Eye T, Hubczak J, Friend SA, Dahm M, Schubauer-Berigan MK, Siegrist K, Lowry D, Bauer AK, Sargent LM, Erdely A [2020]. Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities. Part Fibre Toxicol, Dec 7;17(1):62. ***Best Paper Award for the journal.

9.     Kodali VK, Shoeb M, Meighan TG, Eye T, Friend SA, Hubczak J, Kashon ML, Zeidler-Erdely PC, Antonini JM, Erdely A [2020]. Bioactivity of circulating factors after pulmonary exposure to mild- and stainless-steel welding fumes. Toxicol Sci, Sep 1;177(1):108-120.

10.  Schubauer-Berigan MK, Dahm MM, Toennis CA, Sammons DL, Eye T, Kodali V, Zeidler-Erdely PC, Erdely A [2020]. Association of occupational exposures with ex vivo functional immune response in workers handling carbon nanotubes and nanofibers. Nanotoxicology, Apr;14(3):404-419.

Recent Invited Oral Presentations:

1.     “Understanding Exposure, Hazard Identification, and Human Health Effects: How Ultrafine/Nano Particle Toxicology Influenced Occupational Safety and Health.” Invited Keynote speaker for the combined international meetings of Inhaled Particles and NanOEH Conference sponsored by the British Occupational Hygiene Society held in Manchester, UK in May 2023.

2.     “Particle Risk and Construction Materials.” Investigators from this project organized and chaired a session specific to novel applications in the construction industry at the combined international meetings of Inhaled Particles and NanOEH Conference sponsored by the British Occupational Hygiene Society held in Manchester, UK in May 2023. A session talk was also given by the co-chair (PI of this project) on use of carbon nanotubes in concrete.

3.     “Characterization of aerosolized particles generated during cutting of carbon nanotubes-embedded concrete.” Presentation made at the combined international meetings of Inhaled Particles and NanOEH Conference sponsored by the British Occupational Hygiene Society held in Manchester, UK in May 2023.

4.     “The road traveled for predicting potential human health effects of carbon nanotubes and nanofibers.” An invited talk for the International Particle Toxicology Conference, August 2022.

5.     Presented our invited external case study for the high aspect ratio nanomaterial integrated approaches to testing and assessment (IATA) framework to members of the GRACIOUS project. GRACIOUS Case Study Workshop, May 2021.

6.     Presented our results, conclusions, and recommendations as part of an external case study for the GRACIOUS integrated approaches to testing and assessment (IATA) framework. GRACIOUS Impacts Forum. Final stakeholder engagement and training workshop, September 2021.

7.     “Controlled exposure and toxicity assessments for nanomaterial use in construction.” Invited speaker in an Educational Session titled “Exposures, Toxicity, and Hazard Communication of Nanomaterials in Construction” for the American Industrial Hygiene Conference and Expo, May 2021.

8.     “What We Know About NanoEHS: Human Exposure. An Integrated Approach.” Presented and was a panelist for National Nanotechnology Initiative (NNI) Public NanoEHS Webinar "What We Know About NanoEHS: Human Exposure," which was part of the NanoEHS webinar series. Panelists shared their perspectives on key findings in quantifying and assessing the effects of human exposure to nanomaterials. March 2021.

9.     “Characterization, toxicity, and modeling of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities.” National Nanotechnology Initiative (NNI) Nanotechnology Environmental and Health Implications (NEHI) Working Group, January 2021.

10.  “Understanding the changing exposure and toxicity profile of engineered nanomaterials from production to application.” National Nanotechnology Initiative (NNI) Nanotechnology Environmental and Health Implications (NEHI) Working Group, November 2020.

Graduate Program Affiliations: Cellular and Integrative Physiology

The overall research objective of my laboratory at the National Institute for Occupational Safety and Health (NIOSH) is the understanding of how occupational exposures can potentially cause adverse health effects. The exposures include chemicals, process-derived particulates/chemicals, and engineered nanomaterials. We evaluate effects at the site of exposure, such as the lung following inhalation, as well as systemic effects after exposure which can include immune, neurological, and cardiovascular.

Historically, occupational laboratory research was centered around understanding how a particular toxicant caused established disease, such as seen with asbestos or silica. More recently, research has included the transition into understanding the potential for adverse health effects prior to established human disease, such as seen with engineered nanomaterials. The latter, while a much-preferred approach, requires significant multidisciplinary expertise to properly address a potential health burden before it materializes.  

Our laboratory offers a collaborative approach to answer both existing and emerging concerns. The integration of exposure and toxicity assessments provides context into human health as well as the proper design for human health evaluations for emerging concerns. Our studies utilize acellular, various in vitro approaches, in vivo animal models, ex vivo evaluations, and when necessary, human health studies to address existing and emerging issues.

Research Topics:

1.Combustion source mixtures: Characteristics and investigation of health effects. This project will aid in

2.Plastics – a new emerging global human health concern? Plastics are ubiquitous. Recent evaluations are trying to establish whether any potential link to adverse human health effects or exacerbation of existing disease exists. This project will aid in answering those questions.

3.Occupational exposures and gestation. This project will evaluate occupational toxicants and the effects on pregnancy.

4.Commercialization of engineered nanomaterials. This project will focus on how the application of engineered nanomaterials to large scale everyday existing products effects exposure and potential toxicity.