Sam Mukdadi, PhD

Associate Professor, Mechanical and Aerospace Engineering Associate Professor, Benjamin M. Statler College of Engineering and Mineral Resources

Member

Organization:

West Virginia University WVU Cancer Institute

Department:

WVU Cancer Institute Research Programs

Classification:

Faculty

• PhD, University of Colorado, Boulder, 2002

Most Recent:

High-resolution vascular tissue characterization in mice using 55MHz ultrasound hybrid imaging.
Mahmoud AM, Sandoval C, Teng B, Schnermann JB, Martin KH, Mustafa SJ, Mukdadi OM.
Ultrasonics. 2013;53(3):727-738.
NIHMS422749.

Nonlinear characterization of breast cancer using multi-compression 3D ultrasound elastography in vivo.
Sayed AM, Layne G, Abraham J, Mukdadi OM.
Ultrasonics. 2013;53(5):979-991.
PMC3624066.

Three-dimensional modeling and finite element analysis in treatment planning for orthodontic tooth movement.
Ammar HH, Ngan P, Crout RJ, Mucino VH, Mukdadi OM.
Am J Orthod Dentofacial Orthop. 2011;139(1):e59-e71.

Resonance frequencies of piezoelectric plates surrounded by solid and fluid half-spaces.
Cortes DH, Mukdadi OM.
Journal of Sound and Vibration. 2011;330(23):5558-5568.

Elastic guided wave propagation in a periodic array of multi-layered piezoelectric plates with finite cross-sections.
Cortes DH, Datta SK, Mukdadi OM.
Ultrasonics. 2010;50(3):347-356.

High-resolution 3D ultrasound jawbone surface imaging for diagnosis of periodontal bony defects: an In Vitro study.
Mahmoud AM, Ngan P, Crout RJ, Mukdadi OM.
Ann Biomed Eng. 2010;38(11):3409-3422.

Non-destructive ultrasonic evaluation of CFRP-concrete specimens subjected to accelerated aging conditions.
Mahmoud AM, Ammar HH, Mukdadi OM, Ray I, Imani FS, Chen A, Davalos JF.
Ndt & e International. 2010;43(7):635-641.

In vivo vascular wall tissue characterization using a strain tensor measuring (STM) technique for flow-mediated vasodilation analyses.
Mahmoud AM, Frisbee JC, D'Audiffret A, Mukdadi OM.
Phys Med Biol. 2009;54(20):6217-6238.

Dispersion of elastic guided waves in piezoelectric infinite plates with inversion layers.
Cortes DH, Datta SK, Mukdadi OM.
International Journal of Solids and Structures. 2008;45(18-19):5088-5102.

Atomic-layer deposition for fabricating capacitive micromachined ultrasonic transducers: Initial characterization.
Liu L, Mukdadi OM, Tripp MK, Herrmann CF, Hertzberg JR, George SM, Bright VM, Shandas R.
Sensors and Materials. 2008;20(1):15-34.

Received his Ph.D. degree in December 2002 from the University of Colorado at Boulder. From December 2002 to December 2005 he was a Research Fellow working at the Department of Pediatric Cardiology at the Children's Hospital at Denver and the Department of Mechanical Engineering at the University of Colorado at Boulder. In December 2005, he has been appointed as Assistant Professor of Mechanical and Aerospace Engineering at West Virginia University.

His current research interests are focused on the development of broadband ultrasound transducers for harmonic contrast imaging, biomedical diagnostic and therapeutic ultrasound, cardiovascular biomechanics, ultrasonic nondestructive evaluation techniques, and micro- and nano- material characterization. He has authored/co-authored over 30 technical articles. In 2001, he received an outstanding paper award from American Society of Mechanical Engineers (ASME).

Breast Cancer

My cancer research focus is on 2D and 3D ultrasound imaging of breast tumors and characterization. We have developed a novel technique that is capable for differentiating benign masses from malignant tumors. A tissue nonlinearity based technique was tested in vivo at the cancer center at WVU.

Another focus is the development of hybrid ultrasound-PET imaging modality that could provide structural and functional imaging. The would provide accurate assessment of the tumor size and type noninvasively.  







 







My interdisciplinary research on biomedical imaging and tissue characterization has a strong translational component. We develop our hypothesis based on physical properties and mechanical behavior of tissues and translate it to clinical applications to help accurate and early diagnosis of cancer. Bridging between Physics, Engineering and clinical practice is our research focus to improve the quality of life.

 Novel Molecular Hybrid PET-Ultrasound Imaging System for Early Diagnosis Biopsy Guidance of Prostate Cancer, WVU Program to Stimulate Competitive Research PSCoR, 2012, $28,000, Role: PI.



 Endorectal Prostate Probe with Combined PET and US Modalities, WVU Mary Babb Randolph Cancer Center, PPG grant, $9000, Role: PI.



 Non-Invasive High-Resolution Diagnosis of Periodontal Attachment Levels Using Real-Time Quantitative Ultrasound Imaging, NIH, 2009-2012, $393,750, Role: PI.



 Center for Transportation Security and Infrastructure Innovations, PSCoR RCG, 2007-2012, $1,500,000, Role: co-PI.



 High Frequency 3D Echodentographic Imaging System for Early Diagnosis of Periodontal Disease, WVU Program to Stimulate Competitive Research PSCoR, 2009, $32,666, Role: PI.



 High resolution biomedical imaging for clinical diagnosis, West Virginia EPSCoR, 2006-2007, $50,000, Role: PI.