- West Virginia University WVU Cancer Institute
- WVU Cancer Institute Research Laboratories
- West Virginia University School of Medicine
- Microbiology, Immunology & Cell Biology
- PhD, University of Pittsburgh, School of Medicine, 2007
- MSc, National Autonomous University of Mexico (Universidad Nacional Autónoma de México, UNAM), 2001
Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells.
Barr JA, Hayes KE, Brownmiller T, Harold AD, Jagannathan R, Lockman PR, Khan S, Martinez I.
Sci Rep 2019 Mar 6;9(1):3662.
Immunoprecipitation of Tri-methylated Capped RNA.
Hayes KE, Barr JA, Xie M, Steitz JA, Martinez I.
Bio Protoc. 2018; 8(3).
Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase).
Shepherd DL, Hathaway QA, Pinti MV, Nichols CE, Durr AJ, Sreekumar S, Hughes KM, Stine SM, Martinez I, Hollander JM.
J Mol Cell Cardiol. 2017; 110: 15-25.
An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence.
Martinez I, Hayes KE, Barr JA, Harold AD, Xie M, Bukhari SIA, Vasudevan S, Steitz JA, DiMaio D.
Proc Natl Acad Sci U S A. 2017; 114(25): E4961-E4970.
Bone marrow microenvironment niche regulates miR-221/222 in acute lymphoblastic leukemia.
Moses BS, Evans R, Slone WL, Piktel D, Martinez I, Craig M, Gibson LF.
Mol Cancer Res. 2016; 14(10): 909-919.
Translational regulation of the mitochondrial genome following redistribution of mitochondrial microRNA in the diabetic heart.
Jagannathan R, Thapa D, Nichols CE, Shepherd DL, Stricker JC, Croston TL, Baseler WA, Lewis SE, Martinez I, Hollander JM.
Circ Cardiovasc Genet. 2015; 8(6): 785-802.
MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways.
Hu Z, Klein JD, Mitch WE, Zhang L, Martinez I, Wang XH.
Aging (Albany NY). 2014; 6(3): 160-175.
Damage associated molecular pattern molecule-induced microRNAs (DAMPmiRs) induction in human peripheral blood mononuclear cells.
Unlu S, Tang S, Wang E, Martinez I, Tang D, Bianchi ME, Zeh HJ, Lotze MT.
PLoS One. 2012; 7(6): e38899.
B-Myb, cancer, senescence, and microRNAs.
Martinez I, DiMaio D.
Cancer Res. 2011; 71(16): 5370-5373.
miR-29 and miR-30 regulate B-Myb expression during cellular senescence.
Martinez I, Cazalla D, Almstead LL, Steitz JA, DiMaio D.
Proc Natl Acad Sci U S A. 2011; 108(2): 522-527.
MicroRNAs and senescence.
Martinez I, Almstead LL, DiMaio D.
Aging (Albany NY). 2011; 3(2): 77-78.
Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells.
Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP, Khan SA.
Oncogene. 2008; 27(18): 2575-2582.
Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas.
Martinez I, Wang J, Hobson KF, Ferris RL, Khan SA.
Eur J Cancer. 2007; 43(2): 415-432.
Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): a natural disease model provides insights into viral carcinogenesis.
Ferris RL, Martinez I, Sirianni N, Wang J, Lopez-Albaitero A, Gollin SM, Johnson JT, Khan SA.
Eur J Cancer. 2005; 41(5): 807-815.
High prevalence of RET tyrosine kinase activation in Mexican patients with papillary thyroid carcinomas.
Martinez I, Mantilla A, Medrano ME, Hernandez R, Hernandez DM, Lazos M, Santiago H, Gonzalez B, Hidalgo A, Salcedo M.
Endocr Pathol. 2001; 12(2): 113-123.
[Comparative genomic hybridization: A new strategy for the genetic analysis of cancer].
Hidalgo A, Cheng S, Perez C, Martinez I, Gonzalez B, Salcedo M.
Cienc Desarr. 2000; 152: 27-33.
[The Molecular Diagnosis for Cancer, Topicality and Perspectives].
Salcedo M, Segura J, Arana R, Franco C, Hidalgo A, Martinez I.
Cienc Desarr. 1998; 141: 21-27.
Presence of the 918 mutation in the RET proto-oncogene in a Mexican patient with multiple endocrine neoplasia type 2B.
Hidalgo A, Medrano ME, Rodriguez S, Franco C, Martinez I, Benitez L, Salcedo M.
J Exp Clin Cancer Res. 1998; 17(2): 149-152.
Postdoctoral Fellowship - Yale University, 2007- 2012.
The recent discovery of different classes of non-coding RNAs and their importance in almost every cellular process has opened a new frontier in understanding the regulation of gene expression. The main interest in my laboratory is to study the importance of non-coding RNAs, such as microRNAs (miRNAs) and large intergenic non-coding RNAs (lincRNAs), during the process of carcinogenesis in cells infected by human papillomaviruses (HPVs).
miRNAs are double-stranded ~22 nt RNAs that can base-pair with specific messenger RNA (mRNA) targets and regulate their expression by translational repression or mRNA degradation. Many different miRNAs have been implicated in human cancers, either as oncogenic miRNAs or tumor suppressor miRNAs. In addition, viruses have been associated with 15-20% of all cancers and previous studies have shown that the expression of HPV oncogenes can regulate host miRNAs (such as miR-218) and influence the transcriptional profile of the infected cells. One of the biggest challenges in the miRNA field is to determine the mRNA targets of all miRNAs. By using a technology known as HITS-CLIP (high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation) my lab studies the global interactions between miRNAs and their targets during infection and transformation by HPV in head and neck cancers.
LincRNAs (another class of non-coding RNAs recently discovered) have the ability to regulate gene expression by directly interacting with chromatin-modifying proteins and helping them target specific genomic regions at distant loci. By using global lincRNA expression assays, reporter constructs, mutational and biochemical analyses, as well as functional assays, my lab also wants to explore the importance of lincRNAs in HPV-related cancers. HPV, like most oncogenic viruses, modulate a subset of specific cellular pathways: cell cycle regulation, apoptosis and cellular senescence (a form of irreversible growth arrest and a major tumor suppressor mechanism). Interestingly, the repression of the HPV viral oncogenes in cervical carcinoma cell lines reactivates the expression of the tumor suppressor proteins p53 and Rb which leads to a rapid induction of senescence. Thus, we are also interested in studying the differences in miRNA and lincRNA expression and processing pathways during senescence and other types of growth arrest such as quiescence.
Sara Crile Allen and James Frederick Allen Lung Cancer
Understanding the importance of non-coding RNAs in human papillomavirus-related cancers and models of growth arrest