Knox Van Dyke, PhD

Professor Emeritus

Organization:

West Virginia University School of Medicine

Department:

Biochemistry and Molecular Medicine

Classification:

Unknown

Van Dyke, K., Ghreeb,E., Van Dyke, M., Van Dyke, C., Gunther,M., and Van Thiel ,DH., "Does Nitric Oxide and/or Superoxide cause Type 2 Diabetes and Can it be Prevented?" Biology and Medicine Journal 2014, 6 (1) :1-10.

Sosa, Arturo, J., Chavez, P., Van Dyke, K., "Inhibitory Effect of Tetrandrine and Paclitaxel or Doxorubicin on Multi-Drug Resistant Cancer Cells Associated with MDR ATPase" International Journal of Pharmacotherapy, 2014;4(1): 48-47.

Settle, T., Moritz, J., Leonard, SS, Falkenstein, E., Fix, N., Van Dyke, K., and Klandorf, H., "Effects of a Phytogenic Food Additive Versus an Antibiotic Feed Additive on Oxidative Stress in Broiler Chicks and a Possible Mechanism Determined by Electron Spin Resonance", International Journal of Poultry Science;2013:12, 1-8.

Zuguang Ye, Knox Van Dyke, and Richard Rossan, "Effective Treatment with a Tetrandrine /Chloroquine Combination for Chloroquine Resistant Falciparum Malaria\ in Aotus Monkeys" Malaria Journal 2013;12:117-124.

Van Dyke, Knox; Jabbour, Nabil; Hoeltdke, Robert; Van Dyke Chris; and Van Dyke ,Mark, "Oxidative/Nitrosative (O/N) Stresses Trigger Diabetes I-Preventable in Streptozotocin Rats – and Detectable in Human Disease", in Annals of The New York Academy of Sciences ,1203,138-145, Aug 2010.

Hoeldtke Robert,D; Bryner, Kimberly, D.; Van Dyke, Knox; "Oxidative stress and autonomic nerve function in early type I diabetes in Clinical Autonomic Research" published on line pp 1-10 September 25, 2010.

Chemotherapy & Inflammation

Research is centered in two main areas: chemotherapy and inflammation. These studies include an examination of antimicrobial, antiviral, antimal, and anticancer drugs. Other research is involved with host defense systems and the drugs that affect them.

Description of Research:

Currently we study inflammation by measuring oxidative processes and genetic activation of inflamed tissues and cells. We have examined a variety of air-borne particles which can cause inflammation and eventually fibrosis. We believe the development of fibrosis (scarring) is due to inflammation which occurs chronically. Therefore, by making the particles less toxic (by coating), or by removing particles, the toxic load could be lightened. If that is not the case, then management of the system of chronic inflammation is necessary. We have been successful in regulating the inflammation ,from silica, asbestos and coal in the lung. We are developing new methods (including genetic probes) to control diseases such as black lung, silicosis, fibrosis and emphysema.

Dr. Van Dyke is a member of the Interdepartmental Graduate Program in Genetics.