person

Anna Shvedova, PhD

Adjunct Professor

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Phone
304-285-6177
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NIOSH
Morgantown, WV 26506
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Positions

Adjunct Professor

Organization:
School of Medicine
Classification:
Adjunct Faculty

Publications

Presentations At National And International Meetings

  • Presentations at more than 60 Congresses and Meetings

Patents

  • Antioxidant drug EMOXIPIN is patented as a “Retinoprotector for Treating Intraocular Hemorrhage, Myopic, Chorioretinal Dystrophies, Congenital Retinal Dystrophies, Retinal Burns and Prevention of Injury in Laser Coagulation” in:
    • US 4486440
    • FR 83143339-2551 659
    • CH 658595
    • DE 3330053C2
    • IT 1197696

Full-length manuscripts:

  1. Kagan VE, Shvedova AA, Novikov KN, Kozlov YP. Light-induced free radical oxidation of membrane lipids in photoreceptors of frog retina. Biochem. Biophys. Acta 330: 76-79, 1973.
  2. Novikov KN, Shvedova AA, Kagan VE, Kozlov YP, Ostrowsky MA. Photo- induced changes in photoreceptor membranes and rhodopsin revealed by craft-co-polymerization. Biophys.USSR 19(2): 280-284, 1974.
  3. Sibeldina LA, Kagan VE, Shvedova AA, Novikov KN, Kobelev VS. NMR study of molecular organization of photoreceptor membranes. Proc. Natl. Acad. Sc. USSR 224(2): 228- 231, 1975.
  4. Novikov KN, Kagan VE, Shvedova AA, Kozlov YP. Lipid-protein Interactions in photoreceptor membranes under lipid peroxidation. Biophys. USSR 20 (6): 1039-1042, 1975.
  5. Kagan VE, Shvedova AA, Novikov KN, Kozlov YP. Effects of conformational rearrangements on spontaneous and induced lipid peroxidation in frog retina rod outer segments. Biophys. USSR 20 (6): 1043-1048, 1975.
  6. Novikov KN, Shvedova AA, Tyurin VA, Shukolyukov SA, Kagan VE. On the role of lipid composition in kinetics of phospholipids free radical oxidation in photoreceptor membranes. Biophys. USSR 22 (5): 942-944, 1977.
  7. Kagan VE, Shukolyukov SA, Tyurin VA, Shvedova AA, Korchagin VP, Galuschenko IV. Effects of chemical modification of lipids by molecular oxygen on thermal stability of rhodopsin in photoreceptor membranes of wall-eyed pollock. Studia Biophys. 72 (1): 51-58, 1978.
  8. Kagan VE, Shvedova AA, Novikov KN. Participation of phospholipases in repair of photoreceptor membranes after lipid peroxidation. Biophys. USSR 23 (2): 279-284, 1978.
  9. Shvedova AA, Ostrowsky MA, Bogoslowsky Al, Scherbatova Ol, Zueva MV, Trutneva KV. Damage of the retina by visible light and the role of antioxidant. Excerpta Medica 442: 114, 1978.
  10. Shcherbatova OI, Zueva MV, Shvedova AA, Shamshinova AM, Kaban AA. State of the organ of vision in workers in the diamond-processing industry. Vestn Ophthalmology. 3:56-9, 1980.
  11. Iakovlev AA, Shvedova AA, Ostrovskii MA. Effect of antioxidants on the oxygenation and bio-potentials of the retina (experimental studies). Vestn Oftalmol. 2):37-40, 1978
  12. Kagan VE, Lankin VZ, Shvedova AA, Novikov KN, Dobrina SK, Bratkovskaya LB, Kuliev IY. Enzymic and non-enzymic protective antioxidant systems in photoreceptors. Bull. Exp. Biol. Med. USSR 8:164-166, 1979.
  13. Shvedova AA, Sidorov AS, Novikov KN, Galuschenko IV, Kagan VE. Lipid peroxidation and electric activity of the retina. Vision Res. 19: 49-55, 1979.
  14. Ostrowscky MA, Bogoslowsky AL, Zueva MV, Shvedova AA. Investigation of the mechanisms of visible light injury on the normal animal retina. Vest. Acad. Med. Sci. USSR 12:57-61, 1979.
  15. Korchagin VP, Bratkovskaya LB, Shvedova AA, Arkhipenko YV, Kagan VE, Shukolyukov SA. Oligomerization of intrinsic membrane proteins in the course of lipid peroxidation. Biochem. USSR 45 (10):1767-1772, 1980.
  16. Bratkovskaya LB, Novikov KN, Shvedova AA, Polischuk RF, Kagan VE, Kozlov YP. Pyridine nucleotide-dependent systems of lipid peroxidation induction in retina photoreceptors. Biol. Sciences 6: 21-26, 1981.
  17. Kuliev IY, Shvedova AA, Kagan VE, Krasnovsky AA, Kozlov YP. Light induced damage of the retina: participation of singlet oxygen and lipid peroxidation. Proc. Natl. Acad. Sc. USSR 263(5):1005-1009, 1982.
  18. Shvedova A, Kagan VE, Kuliev IY, Dobrina SK, Prilipko LL, Meerson FZ, Kozlov YP. Lipid peroxidation and damage of the retina in stress exposed rats. Bull. Exp. Biol. Med. USSR 4:24-27, 1982.
  19. Polyansky NB, Smirnov LD, Shvedova AA, Kagan VE, Tkachuk VA. Inhibition of phosphodiesterase of cyclic nucleotide from rabbit heart by 3-hydroxypyridines. Problems Med.Chem. 1: 123-127, 1983.
  20. Shvedova AA, Kagan VE, Kuliev IY, Vekshina OM. Mechanisms of retina damage by fluorescent dyes. Bull. Exp. Biol. Med. USSR 8: 48-50, 1983.
  21. Kagan VE, Bratkovskaya LB, Kuliev IY, Shvedova AA. The role of lipid peroxidation in retina damage under hyperbaric oxygenation and possibility of chemical protection by antioxidants. Proc. Natl. Acad. Sci. USSR 271 (1): 227-230, 1983.
  22. Shvedova AA, Alekseeva OM, Kuliev IY, Muranov KO, Kozlov YP, Kagan VE. Damage of photoreceptor membrane lipids and proteins induced by photosensitized oxidation. Curr. Eye Res.2 (10): 683-690, 1983.
  23. Polyansky NB, Smirov LD, Shvedova AA, Kagan VE. Inhibition of cyclic nucleotide phosphodiesterase from frog rod outer segments by 3-hydroxypyridines. Biol. Sciences 1: 27-31, 1984.
  24. Shvedova AA. Molecular mechanisms of emoxipin effect. In: Emoxipin, Medexport, Moscow, USSR, pp. 2-19, 1984.
  25. Shvedova AA, Fedulov AS, Marchenko LN, Zayats GR. Experimental application of emoxipin in treatment of traumatic hemophthalmia. In: Emoxipin, Medexport, Moscow, USSR, pp. 19-20, 1984.
  26. Katznelson LA, Nikolskaya VV, Beglyarova AS, Shvedova AA. Emoxipin in treatment of exudative forms of retinopathy. In: Emoxipin, Medexport, Moscow, USSR, pp. 21-22, 1984.
  27. Katsnelson LA, Gurtovaya EE, Malyuta GD, Bogdanova LV, Shvedova AA. Emoxipin in treatment of hemophthalmia In: Emoxipin, Medexport, Moscow, USSR, pp.22-23, 1984.
  28. Katsnelson LA, Gurtovaya EE, Nikolskaya VV, Bogdanova LV, Shvedova AA. Emoxipin in treatment of retinal vein thrombosis. In: Emoxipin, Medexport, Moscow, USSR, pp. 24-25, 1984.
  29. Katsnelson LA, Agranovich MS, Gurtovaya EE, Karpova NA, Rosenfeld IA, Shvedova AA. Emoxipin in treatment of central chorioretinal dystrophies (CCRD). In: Emoxipin, Medexport, Moscow, USSR, pp. 25-26, 1984.
  30. Makarskaya NV, Brovkina AF, Shvedova AA, Akhmedzhanova EV. Prospects for emoxipin application in the case of laser destruction of intraocular vascular tumors. In: Emoxipin, Medexport, Moscow, USSR, pp. 32-35, 1984.
  31. Bogdanova LV, Katsnelson LA, Shvedova AA. Medication of laser and sun burns of the retina with emoxipin preparation. In: Emoxipin, Medexport, Moscow, USSR, pp. 38, 1984.
  32. Katsnelson LA, Dnestrova GI, Yelyseyeva RF, Shvedova AA. Application of emoxipin for treatment of stargardt disease. In: Emoxipin, Medexport, Moscow, USSR, pp. 41-43, 1984.
  33. Kleimenov AN, Rozenfel'd MA, Burlakova EB, Zenkov IuV, Shvedova AA. Effect of the antioxidant OP-6 on some model reactions of the blood coagulation system. Vopr Med Khim. 29(1):33-7, 1983
  34. Kagan VE, Polyansky NB, Muranov KO, Shvedova AA, Smirnov LD, Dyumaev KM. Suppression of aggregation and inhibition of phosphodiesterase of cyclic nucleotide in platelets by 3- hydroxypyridines. Bull. Exp. Biol. Med. USSR 4: 41 6-41 8, 1984.
  35. Komarov PG, Bilenko MV, Shvedova AA, Kagan VE. Evaluation of the efficiency of different compounds in inhibition of enzymic lipid peroxidation. Probl. Med. Chem. 2: 40-45, 1985 (in Russian).
  36. Babijaev MA, Shvedova AA, Arkhipenko YV, Kagan VE. Accumulation of lipid peroxidation products in cataract lenses. Bull. Exp. Biol. Med. USSR 9: 299301, 1985.
  37. Muranov KO, Polyansky NV, Shvedova AA, Smirov LD, Kagan VE. Changes in the cyclic nucleotide level and the inhibition of human platelet aggregation upon exposure to 3-hydroxypyridines. Bull. Exp. Biol. Med. USSR 10: 432434, 1986.
  38. Muranov KO, Gashev SB, Smirov LD, Shvedova AA, Ritov VB. Inhibition of platelet aggregation by antioxidants. Bull. Exp. Biol. Med. USSR 3: 337-339, 1986.
  39. Kagan VE, Ivanova SM, Murzakhmetova MK, Shvedova AA, Smirnov LD. Antioxidants-stabilizers to the Ca++-transport enzyme system in sarcoplasmic reticulum membranes in vivo. Bull. Exp. Biol. Med. USSR 11: 52-54, 1986.
  40. Egorov CJ, Babijaev MA, Krasnovsky AA, Shvedova AA. Photosensitized generation of singlet oxygen by endogenous substances of the eye lens. Biophys. USSR 32: 169-172, 1987.
  41. Shvedova AA, Platonov ES, Polyansky NV, Babijaev MA, Kagan VE. The chemical nature of the fluorescent products accumulating in the lipids of the lenses in mice with hereditary cataract. Bull. Exp. Biol. Med. USSR 3: 301-304, 1987.
  42. Shvedova AA, Polyansky NB, Akopyan GK, Dzhafarov Al. Effect of emoxipin on basal cyclic nucleotide phosphodiesterase activity and late receptor potential of isolated retina. Bull. Exp. Biol. Med. USSR 9: 289-291, 1989.
  43. Pashin EN, Shvedova AA. The effect of a synthetic antioxidant emoxipin on coronary vessels tone. Pharmacol. Toxicol. USSR 52: 17-19, 1989.
  44. Egorov EA, Shvedova AA, Obraztsova IA. The results of clinical trial of antioxidant emoxipin in an ophthalmology setting. Vest. Ophthalmol. 5: 52-55, 1989.
  45. Golikov AP, Ovchinnikov VL, Polumiskov VUY, Davydov BV, Karev VA, Konorev LA, Shvedova AA. Antioxidant Emoxipin: The effects on formation of necrotic and reparative processes in myocardial infarction. Cardiol. USSR 7: 50-53, 1990.
  46. Kocherginsky NW, Shvedene NV, Shvedova AA. Detection of emoxipin with a membrane electrode. Chem. Pharmaceut. J. USSR 24 (12): 77-78, 1990.
  47. Horseva Ml, Kocherginsky NW, Shvedova AA. Transport of tetracycline antibiotics through biomimetic membranes. Biotech. Bulgaria 1: 39-43, 1990.
  48. Mishina EV, Filippenko NG, Pichugin VV, Zherdev VP, Lebedev AV, Kameneva NV, Shvedova AA. Pharmacokinetic and pharmacodinamic of Emoxipin under normal and pathological conditions. Bull. Exp. Biol. Med. USSR 10: 389-390, 1990.
  49. Shvedova AA, L'vov KM, Polianskii NB, Bekmurzaev BM. Study of soluble proteins in mouse normal and cataract lenses. Bull. Exp. Biol. Med. USSR, 6: 609-610, 1991.
  50. Kagan VE, Serbinova EA, Maguire JJ, Shvedova AA, Packer L. On the path from ubiquin one to ubiquinol: chain breaking lipid peroxyl radical scavenging or vitamin E radical recycling? In: Oxidative Damage and Repair (Chemical, Biological and Medical Aspects), K.J.A. Davies, Ed., Pergamon Press, 121-125, 1991.
  51. Kagan VE, Shvedova AA, Serbinova EA, Khan S, Swanson K, Powell R, Packer L. Dihydrolipoic acid acts as a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. J. Biochem. Pharmacol. 8:1637-1649, 1992.
  52. Shvedova AA, Kramarik JA, Keohavong P, Chumakov KM, Karol MH. Use of anti-TNF-? antiserum to investigate toxic alveolitis arising from cotton dust exposure. Exp. Lung Res. 20: 297-315, 1994.
  53. Menshikova EV, Ritov VB, Shvedova AA, Elsayed N, Karol MH, Kagan VE. Pulmonary microsomes contain a Ca++-transport system sensitive to oxidative stress. Biochem. Biophys. Acta 1228: 165-174, 1995.
  54. Shvedova AA, Kisin ER, Kagan VE, Karol MH. Increased lipid peroxidation and decreased antioxidants in lungs of guinea pigs following an allergic pulmonary response. Toxicol. Appl. Pharmacol. 132: 72-81, 1995.
  55. Shvedova AA, Menshikova EV, Ritov VB, Kagan VE, Karol MH. Murine pulmonary Ca++-transport system activated by allergic immune response retains sensitivity to oxidative stress. Exp. Lung Res. 21: 743-769, 1995.
  56. Shvedova AA, Satoh T, Tollerud D, Guevarra L, Karol MH. Elevated levels of IL-6, INF-?, and TNF-? in mice in response to cotton dust are modulated by anti-TNF-? antiserum. Exp. Lung Res. 22: 149-161, 1996.
  57. Shvedova AA, Tyurina YY, Gorbunov NV, Tyurin VA, Castranova V, Kommineni C, Ojimba J, Gandley R, McLaughlin M, Kagan VE. tert-Butyl hydroperoxide/hemoglobin-induced oxidative stress and damage to vascular smooth muscle cells. Biochem. Pharmacol. 57: 989-1001, 1998.
  58. Shvedova A, Osipov A, Kommineni C, Jeffries B, Castranova V, Vallyathan V, Kagan V. Peroxidase/H2O2 enhances hypersensitivity responses Induced by eugenol: inhibitory effect of an antioxidant, lipoic acid. Env. Nutr. Interact. 3: 15-31, 1999.
  59. Shvedova AA, Kommineni C, Jeffries B, Castranova V, Tyurina YY, Tyurin VA, Serbinova EA, Fabisiak JP, Kagan VE. Redox cycling of phenol induces oxidative stress in human keratinocytes: evidence for enhanced lipid and thiol oxidation and antioxidant depletion, J. Invest. Derm. 114: 354-364, 2000.
  60. Kagan VE, Kuzmenko AI, Shvedova AA, Kisin ER, Tyurina YY, Yalowich JC. Myeloperoxidase-catalyzed phenoxyl radicals of vitamin E homologue, 2,2,5,7,8-Pentamethyl-6-hydroxylchromane, do not induce oxidative stress in live LH-60 cells. Biochem. Res. Com.270. 1086-1092, 2000.
  61. Kagan VE, Fabisiak JP, Shvedova AA, Tyurina YY, Tyurin VA, Schor NF, Kawai K. Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis. FEBS Letters, 477, 1-7. 2000.
  62. Tyurina YY, Shvedova AA, Kawai K, Tyurin VA, Kommineni C, Quinn PJ, Schor NF, Fabisiak JP, Kagan VE. Phospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine. Toxicology. 148, 93-101, 2000.
  63. Al-Humadi NH, Shvedova AA, Battelli L, Diotte N, Castranova V, Kommineni C. Dermal and systemic toxicity after application of semi-synthetic metal working fluids in B6C3F1 mice. J. Tox. Environ. Health 61:579-589, 2000.
  64. Shvedova AA, Kisin E, Kisin J, Castranova V, Kommineni C. Elevated oxidative stress in skin of B6CF1 mice affects dermal exposure to metal working Fluid. Ind. Toxicol. Ind. Health, 16(7-8):267-76, 2001.
  65. Shvedova AA, Tyurina YY, Tyurin VA, Kikuchi Y, Kagan VE, Quinn, PJ. Quantitive Analysis of phospholipid peroxidation and antioxidant protection in live human keratinocytes, Bioscience Reports, 21(1):33-43, 2001.
  66. Kagan VE, Kozlov AV, Tyurina YY, Shvedova AA, Yalowich JC. Antioxidant mechanisms of NO against iron-catalyzed oxidative stress in cells. Antioxidants and Redox Signal. 3(2):189-202, 2001.
  67. Kagan VE, Kuzmenko AI, Tyurina YY, Shvedova AA, Matsura T, Yalowich JC. Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase. Cancer Res. 61(21):7777-84, 2001.
  68. Shvedova AA, Tyurina BYY, Kawai K, Tyurin VA, Kommineni C, Castranova V, Fabisiak JP, Kagan VE. Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide. J. Invest. Dermatol. 118(6):1008-18, 2002.
  69. Johnson EA, Shvedova AA, Kisin E, O’Callaghan JP, Kommineni C, Miller, DB. D-MDMA during oxidative stress: effects on dopaminergic neurotoxicity and hepatotoxicity. Brain Res. 933 (2) 150-163, 2002.
  70. Kagan VE, Shvedova AA, Tyurina YY, Tyurin VA, Fabisiak JP, Schor NF. Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling. Redox Cell Biology & Genetics, Methods in Enzymology 352:159-74, 2002.
  71. Tyurina YY, Tyurin VA, Liu SX, Smith CA, Shvedova AA, Schor NF, Kagan VE. Phosphatidylserine peroxidation during apoptosis. A signaling pathway for phagocyte clearance. Subcell Biochem. 36:79-96. Review, 2002.
  72. Kagan VE, Kisin ER, Kawai K, Serinkan BF, Osipov AN, Serbinova EA, Wolinsky I, Shvedova AA. Towards mechanisms-based antioxidant interventions: lessons from natural antioxidants. Ann. N.Y Acad Sci. 959: 188-199, 2002.
  73. Modriansky M, Tyurina YY, Tyurin VA, Matsura T, Shvedova AA, Yalowich JC, Kagan VE. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants? Toxicology, (1):105-17, 2002.
  74. Shvedova AA, Kisin ER, Murray AR, Smith S, Castranova V, Kommineni C. Enhanced Oxidative Stress in the skin of vitamin E deficient mice exposed to semi-synthetic metal working fluid. Toxicology, 176(1-2):135-43, 2002.
  75. Shvedova AA, Kisin ER, Murray AR, Goldsmith T, Reynolds JS, Castranova V, Frazer DG, Kommineni C. Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets. Toxicology, 177(2-3):285-297, 2002.
  76. Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova V, Mason RP, Kadiiska MB, Gunther MR, Antioxidant Balance and Free Radical Generation in Vitamin E-Deficient Mice after Dermal Exposure to Cumene Hydroperoxide. Chem Res Toxicol.15(11):1451-1459, 2002.
  77. Tyurina YY, Tyurin VA, Shvedova AA, Fabisiak JP, KaganVE. Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling. Methods Enzymol. 352:159-74, 2002.
  78. Kagan VE, Kuzmenko A.I, Shvedova AA, Kisin E.R., Li R., Martin I., Quinn P.J., Tyurin V.A., Tyurina Y.Y., Yalowich J.C.. Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells. Bioch. Bioph. Acta , 2003, 1620(1-3):72-84.
  79. Kagan VE, Borisenko GG, Serikan BF, Tyurina YY, Tyurin VA, Jiang J, Liu SX, Shvedova AA, Fabisiak JP, Fadeel B. Appetizing rancidity of apoptotic cells for macrophages: oxidation/externalization/recognition of phosphatidylserine. Am. J. Phys., 2003, 285(1):L1-17.
  80. Shvedova AA, Kisin ER, Murray AR., Schwegler-Berry D, Gandelsman VZ, Maynard A, Paul Baron, Castranova V. Exposure to carbon nanotube material II: assessment of the biological effects of nanotube materials using human keratinocytes. J. Tox. Env.Health, 66, 1901-1918, 2003
  81. Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V. Exposure to Carbon Nanotube Material I: Aerosol Release During the Handling of Unrefined Single Walled Carbon Nanotube Material. J. Tox. Env. Health, 2004, 67(1):87-107
  82. Shvedova AA, Kisin ER, Murray A, Kommineni C, Vallyathan V, Castranova V. Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer. Biochemistry (Moscow), 2004, 69 (1), 23-31
  83. Shvedova A, Kisin E, Murray A, Schwegler-Berry D, Gandelsman V, Baron P, Maynard A, Gunter M, Castranova V. Exposure of human bronchial cells to carbon nanotubes caused oxidative stress and cytotoxicity. Proceedings of the Meeting of the SFRR Europe (June 26-29, 2003), Vol. ISBN 88-7587-002; CD ISBN 88-7587-003-9, 2004 http://www.monduzzi.com/proceedings/moreinfo/20030627.htm
  84. Matsura T, Masachika K, Yamada K, Shvedova AA, Kagan VE. Fine-tuning phagocytic clearance of apoptotic cells by phosphatidylserine oxidation. J. Clin. Biochem. & Nutr., 34, 11-24, 2003
  85. Jiang J, Borisenko GG, Osipov A, Martin I, Chen R, Shvedova AA, Sorokin A, Tyurina YY, Potapovich A, Tyurin VA, Graham SH, Kagan VE. Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells. J Neurochem. 90 (5):1036-49, 2004
  86. Shvedova A, Kisin E, Murray A, Schwegler-Berry D, Gandelsman V, Baron P, Maynard A, Gunter M, Kagan V.E., Castranova V. Assessment of Carbon Nanotube Cytotoxicity Using Human Cells and Animal Models. Proceeding of the Toxicology Forum 29th Annual meeting, p. 697-710 (Feb, 2-4, Washington, DC, 2004), 2004 (http://www.toxforum.org/Winter_2004.pdf)
  87. Heck DE, Kagan VE, Shvedova AA, Laskin JD. An Epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary massive concerning origins of apoptosis. Toxicology. 208(2):259-71, 2005
  88. Shvedova A, Kisin E, Mercer R, Murray A, Johnson VJ, Potapovich A, Tyurina Y, Gorelik O, Arepalli S, Schwegler-Berry D, Antonini J, Evans DE, Ku B-K, Ramsey D, Maynard A, Kagan V.E., Castranova V, Baron P. Unusual inflammatory and fibrogenic pulmonary responses to single walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol. 289, L698-L708, 2005
  89. Kagan VE, Bayir H, Shvedova A. Nanomedicine and nanotoxicology: Two sides of the same coin. J. Nanomedicine: Nanotechnology, Biology and Medicine 1, (4), 313-316, 2005
  90. Kagan, A.I. Potapovich, A.N. Osipov, Y.Y. Tyurina, E.R. Kisin, D. Schwegler-Berry, R. Mercer, V. Castranova, A.A. Shvedova. Oxidative interactions of single walled carbon nanotubes with RAW 264.7 macrophages: role of iron. Toxicol Lett. 165(1):88-100, 2006
  91. Bayir H, Fadeel B, Palladino MJ, Witasp E, Kurnikov IV, Tyurina YY, Tyurin VA, Amoscato AA, Jiang J, Kochanek PM, DeKosky ST, Greenberger JS, Shvedova AA, Kagan VE. Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria. Biochim Biophys Acta. 1757(5-6):648-59, 2006.
  92. Kagan VE, Tyurina YY, Bayir H, Chu CT, Kapralov AA, Vlasova II, Belikova NA, Tyurin VA, Amoscato A, Epperly M, Greenberger J, Dekosky S, Shvedova AA, Jiang J The "pro-apoptotic genies" get out of mitochondria: Oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes.Chem Biol Interact.163 (1-2):15-28, 2006
  93. Li Z, Hulderman T, Salmen R, Chapman R, Leonard SS, Young SH, Shvedova A, Luster MI, Simeonova PP. 2006. Cardiovascular Effects of Pulmonary Exposure to Single-Wall Carbon Nanotubes Environ Health Perspect: 115(3):377-82, 2007
  94. Murray A, Kisin ER, Kommineni C, Vallyathan V, Castranova V, Shvedova AA. Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide. Carcinogenesis 28(7):1582-8, 2007
  95. Tyurina YY, Basova LV, Konduru NV, Tyurin VA, Potapovich AI, Cai P, Bayir H, Stoyanovsky D, Pitt BR, Shvedova AA, Fadeel B, Kagan VE. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: Implications for the resolution of inflammation. J Biol Chem. 282(11):8498-509,2007
  96. Shvedova AA, Sager T, Murray AR, Kisin E, Porter DW, Leonard SS, Schwegler-Berry D, Robinson VA, Castranova V. Critical issues in the evaluation of possible adverse pulmonary effects from airborne nanoparticles. Nanotoxicology, Characterization, Dosing and Health Effects. Publisher: Informa Healthcare, USA Inc, NY, London, 2007
  97. Kagan VE, Rao KMK, Kisin ER, Young S-H, Meighan T, Murray AR, Tyurina YY, Castranova V, Shvedova AA. Pulmonary Effects of single-walled carbon nanotubes: inflammatory response, oxidative stress/signaling, and recognition by macrophages. Nanotechnology-Toxicological issues and environmental safety, 65-75, Publisher: Springer, 2007
  98. Shvedova AA, Kisin ER, Murray AR, Gorelik O, Arepalli S, Castranova V, Young SH, Gao F, Tyurina YY, Oury TD, Kagan VE. Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice. Toxicol Appl Pharmacol. 2007 221(3):339-48, 2007.
  99. Fadeel B, Kagan V, Krug H, Shvedova A, Svartengren M, Tran L, Wiklund L. There’s plenty of room at the forum: Potential risks and safety assessment of engineered nanomaterials. Nanotoxicology, 1 (2), 73-84, 2007
  100. Murray AR, Kisin ER, Castranova V, Gunther MR, Kommineni C. Shvedova AA. Phenol- induced in vivo oxidative stress in skin: evidence for enhanced free radical generation, thiol oxidation, and antioxidant depletion. Chem. Res. Toxicol. 20(12):1769-77.
  101. Kisin ER, Murray AR, Keane MJ, Shi XC, Schwegler-Berry D, Gorelik O, Arepalli S, Castranova V, Wallace WE, Kagan VE, Shvedova AA. Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells. J Tox Env Health A. 70(24):2071-9, 2007
  102. Baron PA, Deye GJ, Chen B-T, Schwegler-Berry D, Shvedova AA, Castranova V. Aerosolization of Single-Walled Carbon Nanotubes for an Inhalation Study. Inhal Tox (20):8, 751 – 760, 2008
  103. Mercer RR, Scabilloni J, Wang L, Kisin E, Murray AR, Schwegler-Berry D, Shvedova AA, Castranova V. Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model. Am J Physiol Lung Cell Mol Physiol. 294(1):L87-97, 2008
  104. Shvedova AA, Fabisiak JP, Kisin ER, Murray AR, Roberts JR, Tyurina YY, Antonini JM, Feng WH, Kommineni C, Reynolds J, Barchowsky A, Castranova V, Kagan VE. Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity. Am J Respir Cell Mol Biol. Vol. 38. pp 579–590, 2008
  105. Shvedova AA, Kisin E, Murray AR, Kommineni C, Castranova V, Fadeel B, Kagan VE. Accumulation of neutrophils and decreased fibrosis in NADPH oxidase-deficent C57BL/6 mice exposed to carbon nanotubes. Tox. Appl. Pharm. 231(2):235-40, 2008.
  106. Shvedova AA, Kisin E, Murray AR, Johnson, VJ, Gorerlik O, Arepalli S, F. Hubbs, R. R. Mercer, P. Keohavong, N. Sussman, J. Jin, J. Yin, S. Stone, B. T.Chen, G. Deye, A. Maynard, V. Castranova, P. A. Baron, V. E. Kagan. Am J Physiol Lung Cell Mol Physiol., 295(4):L552-65, 2008
  107. Elder A, Lynch I, Grieger K, Chan-Remillard S, Gatti A, Gnewuch H, Kenawy E-R, Korensten R, Kuhlbusch T, Linker F, Matias S, monteiro-Riviere N, pinto V, Rudnitsky R, Savolainen K, Shvedova A. Disposition of Nanoparticles as a Function of their Interactions with Biomolecules. In “Nanomaterials Risks and Benefits”, Eds. Linkov & Steevens, Springer, pp 4-19, 2009 (Proceedings of the NATO Advanced Research Workshop on Nanomaterials: Environmental Risks and Benefits” Faro, Portugal 27-30 April 2008).
  108. Shvedova AA, Kisin ER, Porter D, Schulte P, Kagan VE, Fadeel B, Castranova V, Mechanisms of Pulmonary Toxicity and Medical Applications of Carbon Nanotubes: Two Faces of Janus? Pharmacol. Ther. December 6, 2008, PMID: 19103221. [Epub ahead of print]
  109. Murray AR, Kisin ER, Leonard SS, Houng SH, Kommineni C, Kagan VE, Castranova V, Shvedova AA. Oxidative Stress and Inflammatory Response in Dermal Toxicity of Single-Walled Carbon Nanotubes, Toxicology, 2009 [in press]
  110. Konduru N, Tyurina YY, Fen W, Basova LV, Belikova NA, Hülya Bayir1, Clark K, Rubin M, Stolz D, Vallhov H, Scheynius A, Witasp E, Bengt Fadeel6, Kichambare PD, Star A, Kisin ER, Murray AR, Anna A. Shvedova AA, a Kagan VE. Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PloS ONE, 2009 [in press]
  111. Tyurin VA, Tyurina YY, Jung Mi-Y, Tungekar MA, Wasserloos KJ, Bayir H, Greenberger JS, Kochanek PM, Shvedova AA, Pitt B, Kagan VE. Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues. J. Chomatogr., 2009 [in press]

Selected Presentations (1990-01)

  1. Kagan V, Khan S, Swanson C, Shvedova A, Serbinova E, Packer L. Antioxidant action of thioctic and dihydrolipoic acid. Free Radical Biology 8 Medicine 9: 15, 1990, Oxidative Damage & Repair, Int. Med. of Society of Free Radical Research, Pasadena, 1990.
  2. Shvedova AA, Kramarik JA, Keohavong P, Chumakov KM, Karol MH. Expression of TNF-? in vivo after cotton dust exposure. Cytokines and Lung Function, FASEB, Saxton's River, Vermont, 1993.
  3. Shvedova AA, Kramarik JA, Keohavong P, Karol MH. Role of TNF-? in development of toxic alveolitis following inhalation of cotton dust. Society of Toxicology Annual Meeting, Dallas, 1994.
  4. Shvedova AA, Stoyanovsky DA, Graham C, Kagan VE, Karol MH. The relationship between TNF-?, pro- and antioxidant factors in eosinophilic inflammation following allergic airway constriction in guinea pigs. American Lung Association/American Thoracic Society International Conference, Boston, 1994.
  5. Shvedova AA, Menshikova EV, Ritov VB, Kagan VE, Karol MH. Allergic immune response activates calcium transport in murine lungs. Society of Toxicology Annual Meeting, Baltimore, 1995.
  6. Shvedova AA, Karol MH, Kagan VE. Role of free radical intermediates in hypersensitivity responses induced by eugenol. International Congress of Toxicology – VII, Seattle, 1995.
  7. Shvedova A, Osipov A, Karol M, Kagan V. Peroxidase/H202 enhances hypersensitivity responses induced by eugenol: Inhibitory effects of an Antioxidant, Lipoic Acid. The Second International Meeting on Oxygen/Nitrogen Radicals and Cellular Injury, Durham, NC, 1997.
  8. Shvedova AA, Tyurina YY, Tyurin VA, Gorbunov NV, Castranova V, McLaughlin M, Ojimba J, Gandley R, Kagan VE. Nitric Oxide but not nitrosothiols inhibit tert-butyl hydroperoxide/hemoglobin-induced oxidative stress and cytotoxicity. Society of Toxicology Annual Meeting, Seattle, WA, March 1-5, 1998.
  9. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Castranova V, Kagan VE. Lipid peroxidation in human epidermal keratinocytes induced by redox-cycling of phenol. International Conference of Chemistry of Organic Peroxides. Moscow, Russia, June15-18, 1998.
  10. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Castranova V, Kagan VE. Redox-cycling and cytotoxicity of phenol in keratinocytes: evidence for enhanced lipid and thiol oxidation and antioxidant depletion. III Int. Congress of Pathophysiology. Lahti, Finland, June 28-July 03, 1998.
  11. Shvedova AA, Tyurina YY, Tyurin VA, Kommineni C, Jeffries BA, Castranova V, Kagan VE. Free Radical mechanism(s) of cytotoxicity of phenolic compounds to skin. IX Biennial Meeting International Society for Free Radical Research. September 7-11, 1998.
  12. Shvedova AA, Tyurina YY, Tyurin VA, Jeffries B, Kommineni C, Castranova V, Kagan VE. Combination of phenolic compounds with arachidonic acid induces Afutile thiol pumping@ and oxidative stress in epidermal human keratinocytes. Society of Toxicology Annual Meeting, New Orleans, March 2-8, 1999.
  13. Al-Humadi NH, Kommineni C, Shvedova AA, Battelli L, Castranova V. Adverse responses to semi-synthetic metal working fluids in B6C3F1 Mice. Society of Toxicology Annual Meeting, New Orleans, March 2-8, 1999.
  14. Shvedova AA, Kommineni C, Tyurina YY, Tyurin VA, Castranova V, Kagan VE. Toxic effects of phenolics to skin. Advances in the Biology and Treatment of the Skin, Piscataway, NJ. June 23 - 25, 1999.
  15. Kommineni C, Kisin ER, Ebeling A, Al-Humadi N, Castranova V, Shvedova AA. Oxidative stress affects dermal exposure to metal working fluid in B6CF1 mice. 14-th Annual Conference, Foundations of Immunotoxicology, Morgantown, September 8-10, 1999.
  16. Shvedova AA, Kisin ER, Kommineni C, Schwegler-Berry D, Tyurina YY, Tyurin VA, Castranova V, Kagan VE. Redox-cycling of occupational phenolic compounds induces oxidative stress and cytotoxicity in human epidermal keratinocytes. SFRR Meeting, Bio-Flavonoids & Polyphenols in Health and Diseases, December 2-5, Dinard, France, 1999.
  17. Johnson E, Shvedova A, Kisin E, O'Callaghan JP, Kommineni C, Miller D. Vitamin E deficiency increases susceptibility of the BALB/C mice to MDMA-induced dopaminergic neurotoxicity. Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000.
  18. Kagan VE, Tyurina YY, Tyurin VA, Kawai K, Fabisiak JP, Kommineni C, Castranova V, Shvedova A. Oxidative stress in keratinocytes: role in apoptotic signaling. Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000.
  19. Kisin E, Kommineni C, Tyurina YY, Tyurin VA, Schwegler-Berry D, Castranova V, Kagan VE, Shvedova A. Redox-cycling of phenols cause depletion of GSH, oxidative stress and cytotoxicity in normal human epidermal keratinocytes (NHEK). Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000.
  20. Kommineni C, Kisin ER, Al-Humadi N, Castranova V, Shvedova AA. Elevated oxidative stress in skin of B6CF1 mice affects dermal exposure to metal working fluid, Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000.
  21. Kisin E, Kommineni C, Tyurina YY, Tyurin VA, Schwegler-Berry D, Castranova V, Kagan VE, Shvedova AA. Redox-cycling of phenols cause depletion of GSH, oxidative stress and cytotoxicity in normal human epidermal keratinocytes (NHEK). Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000.
  22. Shvedova AA, Kisin E, Kommineni C, Mason RP, Kadiiska MB. Antioxidant balance and free radical generation in vitamin E deficient mice after dermal exposure to cumene hydroperoxide. Society of Toxicology Annual Meeting, Philadelphia, March 19-23, 2000.
  23. Kagan VE, Shvedova AA. Phenolic antioxidants and pro-oxidants: are they really so different? Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001.
  24. Smith C, Kisin E, Murray A, Castranova V, Kommineni C, Shvedova AA. Oxidative stress in the skin of vitamin E deficient mice exposed to metal working fluid. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001.
  25. Shvedova AA, Kisin E, Murray A, Castranova V, Kommineni C, Gunter MR. Phenol induced in vivo oxidative stress in skin: evidence for enhanced free radical generation, thiol oxidation and antioxidant depletion. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001.
  26. Al-Humadi NH, Shvedova AA, Kommineni C. Used semi-synthetic metal working fluid (UMWF) dermal and systemic effects in B6C3F1 mice. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001.
  27. Shvedova AA, Tyurina YY, Tyurin VA, Kisin ER, Kikuchi Y, Quinn PJ, Kagan VE. Superoxide-induced reduction of coenzyme Q and its interaction with vitamin E synergistically protects human keratinocytes against oxidative stress. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2v001.
  28. Kagan VE, Kuzmenko AI, Tyurina YY, Kisin ER, Shvedova AA, Yalowich JC. Lipoate/Ascorbate-dependent recycling prevents myeloperoxidase-catalyzed oxidation of vitamin E homologues phenoxyl radical in live HL-60 cells. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001.
  29. Kisin E, Smith C, Murray A, Kisin J, Kommineni C, Castranova V, Kagan V, Shvedova AA. Phenolic Compounds Cause Depletion of GSH, Oxidative stress and cytotoxicity in normal human dermal cells. Society of Toxicology Annual Meeting, San Francisco, March 25-29, 2001.
  30. Shvedova AA, Kisin E, Kawai K, Kagan VE. Antioxidant Interactions and Biomarkers of Oxidative stress in skin and keratinocytes as they relate to apoptosis and aging. 9th Congress International Association of Biomedical Gerontology, Vancouver, B.C. Canada, June 27-30, 2001.
  31. Shvedova AA, Kisin E, Murray A, Goldsmith T, Reynolds JS, Castranova V, Frazer DG, Kommineni C. Sub-chronic effects of metal working fluids on pulmonary functions in B6C3F1 mice: role of vitamin E. Society of Toxicology Annual Meeting, Nashville, March 17-21, 2002.
  32. Shvedova AA, Kisin ER, Kommineni C, Castranova V, Mason RP, Kadiiska MB, Gunther MR. Cumene Hydroperoxide induces depletion of antioxidants and free radical formation in skin of vitamin E-deficient mice. The 13th Japanese Annual Vitamin E Meeting, Hiroshima, Japan, January 17-21, 2002.
  33. Shvedova AA, Kisin ER, Murray AR, Kawai K, Castranova V, Howard PC. Oxidation biomarkers and antioxidant protection of skin against UV-irradiation and chemical exposure. Reactive Oxygen and Nitrogen Species: Diagnostic, Preventive, and Therapeutic Values. International Symposium, Russia, July 9-13, 2002.
  34. Shvedova AA, Kisin ER, Murray AR, Mason RP, Kadiiska M, Castranova V, Gunther M. In vivo detection of vitamin E-dependent protection against free radical formation and oxidative stress in skin treated with cumene hydroperoxide. 9th Annual Meeting, Oxygen Society, San Antonio, TX, Nov. 20-24, 2002
  35. Shvedova AA, Kisin ER, Kommineni C, Gunter MR, Rao MK, Castranova V. Inflammatory response and free radical formation in skin of B63CF1 mice with diminished levels of glutathione after phenol exposure. 42nd Ann. Meeting SOT, Salt Lake City, UT, March 9-13, 2003
  36. Shvedova AA, Murray AR, Kisin ER, Kagan VE, Gandelsman VZ, Castranova V. Exposure of human bronchial epithelial cells to carbon nanotubes caused oxidative stress and cytotoxicity. Free Radicals and Oxidative Stress: Chemistry, Biochemistry and Pathophysiological Implications, SFRR Meeting, June 26-29, 2003, Ioannina, Greece
  37. Shvedova AA, Tyurina YY, Kawai K, Tyurin VA, Castranova V, Kagan VE. Oxidative Phospholipid Signaling During Apoptosis in Keratinocytes. Clearance of Dying Cells by Phagocytes: Mechanisms & Consequences. Gordon Res. Con. New London, CT, Aug 3-8, 2003
  38. Baron P., Maynard A, Shvedova AA, Kisin E., Castranova V. Preliminary studies of generation, exposure, and toxicity of carbon nanotubes. Am. Ass. Aeros Res. Meeting, October 20-24, 2003 Anaheim, CA
  39. Xu, M, Kisin, A. R. Murray, C. Kommineni, V. Vallyathan, V. Castranova, A.A. Shvedova. Activation of AP-1 and Pro/Antioxidant Status in Skin of AP-1 Transgenic Mice During Cancer Promotion with Cumene Hydroperoxide. 43th Society of Toxicology meeting, Baltimore, March 21-25, 2004
  40. Murray A, Kisin E, Kawai K, Kagan VE, Kommineni C, Castranova V, Shvedova AA. Role of Vitamin E in the Antioxidant Defense System of Skin in Young and Old Mice Exposed to Cumene Hydroperoxide, 43th Society of Toxicology meeting, Baltimore, March 21-25, 2004
  41. Shvedova A.A. Pulmonary Toxicity of Carbon Nanotubes: From Cellular Responses to Animal Model. Nanoscale Materials and Public Health. Toxicology Forum. February 2-4, 2004, Washington DC
  42. Shvedova A.A., Kisin E, Keshava N, Murray A.R, Gorelik O, Arepalli S, GandelsmanV.Z, Castranova V. Cytotoxic and genotoxic effects of single wall carbon nanotube exposure on human keratinocytes and bronchial epithelial cells, 227th ACS National Meeting, March 28-April 1, 2004, Anaheim, CA
  43. Shvedova A.A. Pulmonary toxicity of carbon nanotubes. International congress on nanotechnology, San Francisco, CA, Nov 7-10, 2004
  44. Shvedova A.A., Kisin E, Murray A.R, Gorelik O, Arepalli S, GandelsmanV.Z, Mercer B, Hubbs A, Kagan VE, Castranova V. Oxidative stress and pulmonary toxicity of carbon nanotubes.11TH Annual meeting SFRBM, November 17-21, 2004
  45. Shvedova AA. Pulmonary toxicity of carbon nanotube: what we know and what we do not know. National Nanotechnology Infrastructure Network (NNIN): Nanosafe: A workshop on Environmental Health and Safety in Nanotechnology Research, Atlanta, GA, Dec 1-3, 2004 http://snf.stanford.edu/Links/NanosafetyAgenda.html
  46. Shvedova AA. Pulmonary response to carbon nanotubes. 44th Society of Toxicology meeting, New Orleans, March 6-10, 2005
  47. Mercer R., Scabilloni J, Kisin E, Gorelik O, Arepalli S, Murray AR, Castranova V, Shvedova AA Responses of lung parenchyma to carbon nanotubes. 44th Society of Toxicology meeting, New Orleans, March 6-10, 2005
  48. Shvedova AA. Comparative toxicity of nanomaterials in vivo and in vitro. 229th American Chemical Society meeting, San Diego, CA, March 12-16, 2005
  49. Shvedova AA. Unusual pulmonary response to carbon nanoparticles. First Annual Meeting of American Academy of Nanomedicine. Johns Hopkins University, MD, August 15-16, 2005
  50. Shvedova AA. Pulmonary oxidative stress, inflammation, and fibrosis induced by single wall carbon nanotubes. 2nd International Symposium on Nanotechnology and Occupational Health, Minneapolis, MN, October 3-6, 2005
  51. Shvedova AA. Pulmonary toxicity of carbon nanotubes. 8th International Conference on Mechanisms of Action of Inhaled Fibers, Particles, and Nanoparticles in Lung and Cardiovascular Diseases, October 25 – 28, 2005, Research Triangle Park, NC
  52. Shvedova AA. Oxidative stress and pulmonary toxicity of carbon nanotubes. 1st International Meeting “Nanotoxicology: Biomedical Aspects”, January 28 – February 1, 2006, Miami Beach, FL
  53. Shvedova AA. Single-walled carbon nanotubes induced oxidative stress, acute inflammation and pulmonary fibrosis. 45th Society of Toxicology meeting, San Diego, March 5-9, 2006
  54. Shvedova AA. Animal studies: pulmonary toxicity of nanomaterials/carbon nanotubes. Nobel Forum. Mini-Symposium on nanotoxicology: potential risks and safety assessment. Stockholm, Sweden, November 27, 2006
  55. Shvedova AA. and Kagan VE. Pulmonary Toxicity of Carbon Nanotubes. International Conference on Nanotechnology: Occupational and Environmental Health & Safety: Research to Practice, Cincinnati, OH, December 4-7, 2006
  56. Murray AR, Kisin E, Kommineni C, Kagan VE, Castranova V, Shvedova AA. Single-Walled Carbon Nanotubes Induce Oxidative Stress and Inflammation in Skin. 46th Society of Toxicology Meeting, Charlotte, NC, March, 25-29, 2007
  57. Shvedova AA., Kisin ER, A. Murray A, O. Gorelik O, Arepalli S, Castranova V, Young S-H, F. Gao F, Tyurina YY, Oury T, Kagan VE. Vitamin E deficiency enhanced pulmonary response and oxidative stress induced by single-walled carbon nanotubes in C57B6/L mice. 46th Society of Toxicology Meeting, Charlotte, NC, March, 25-29, 2007
  58. Shvedova AA. Pulmonary Toxicity of Singled-Walled Nanotubes. International Conference on Nanotoxicology, Venice, Italy, April,19-21, 2007
  59. Shvedova AA. Pulmonary Toxicity of Nanoparticles. Experimental Biology Meeting, Washington DC, April 30-May 3, 2007
  60. Shvedova AA. Kagan VE. Oxidative stress, pulmonary response and progressive fibrosis induced by exposure to singled-walled nanotubes. Vth International Conference on Peroxynitrate and Reactive Nitrogen Species, Montevideo, Uruguay, September 2-6, 2007.
  61. Shvedova AA. Pulmonary Toxicity of Single-Walled Nanotubes in vivo: Mechanisms and Consequenses. 3rd NASA-NIST Workshop on Nanotube Measurements, NIST, Gaithersburgh, MD, USA, Sep 26-28, 2007
  62. Shvedova AA. Inhalation Exposure to Single-Walled Carbon Nanotubes. European NanOSH Conference –Nanotechnologies: A Critical Area in Occupational Safety and Health, Helsinki, Finland, 3–5 December 2007
  63. Shvedova AA. Single-Walled Carbon Nanotubes: Are They Mutagenic? Mary Babb Randolph Cancer Center – National Institute of Occupational Safety and Health MBRCC - NIOSH Scientific Retreat in Cancer, Morgantown, West Virginia, February 12, 2008
  64. Murray AR, Kisin ER, Leonard S, Kommineni C, Kagan VE, Castranova V, Shvedova AA. Induction of Oxidative Stress and Inflammation in the Skin Following Exposure to Single-Walled Carbon Nanotubes, Zurich, March 12-15, 2008
  65. Shvedova AA. Kagan VE. Pulmonary Toxicity of Carbon Nanotubes In Vivo: Mechanisms, Regulations, and Reality. “Nanomaterials: Environmental Risks and Benefits and Emerging Consumer Products” Faro, Portugal, 27-30, April, 2008
  66. Shvedova AA. "Carbon Nanotube in the Rodent Lungs: Recognition and Modulation of Toxicity". ATS, International Conference, Toronto, Canada, May 16-21, 2008.
  67. Shvedova AA. Relevant to animal studies: Aspiration vs Inhalation. Nanotoxicology, 2nd International meeting, Zurich, Switzerland, September 7-10, 2008.
  68. Shvedova AA., Kisin ER, Murray AR, Kommineni C, Castranova V, Fadeel B, Kagan VE. NADPH oxidase regulates neutrophils and fibrosis in C57BL/6 mice exposed to carbon nanotubes. 48th Annual SOT Meeting, Baltimore, MD, March 15-19
  69. Shvedova AA. Nanotoxicology In Vivo: Pulmonary Effects of Carbon Nanotubes. 6th Symposium on Nanomedicine, Royal Swedish Academy of Sciences, Stockholm, Sweden, September 9-11, 2009.
  70. Shvedova AA. Carbonaceous nanotubes in the lung: mechanisms of damage and consequences. 4th Symposium of the Center for Disease Biology and Integrative Medicine: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease, Tokyo, Japan, October 26-27, 2009
  71. Shvedova AA. Unsolicited pulmonary effects of carbon nanotubes: genetic, nutritional and microbial factors. 4th Oxygen/Nitrogen Radicals and Cellular Injury Meeting, NY Academy of Sciences, New York, USA, October 28-30

Awards

  • Bronze and Silver Awards for Achievements in Economics and Science (USSR, 1989, 1990)
  • Award for Scientific Achievements, the Institute of Chemical Physics, USSR, 1988
  • Award for Scientific Achievements and Merit, the Academy of Sciences USSR, 1989, 1990
  • Award of a grant from NIEHS (#ES05651), 1992-1995
  • Award for outstanding service as the President-Elect of the Allegheny-Erie Regional Chapter of the Society of Toxicology, 1998
  • Special recognition award for service as the President of the Allegheny-Erie Regional Chapter, the Society of Toxicology, 1999
  • Certificate of appreciation for outstanding service to the Allegheny-Erie Regional Chapter, the Society of Toxicology as Past President, 2000
  • Award for meritorious service as founding President of the Dermal Toxicology Specialty Section, the Society of Toxicology, 2001
  • The Society of Toxicology Public Communication Award for recognition of major contributions to broadening the awareness of the general public to toxicological issues, 2001
  • Fellow of the Academy of Toxicological Sciences, 2001- current
  • The Society of Toxicology Women in Toxicology Service Recognition Award, 2006
  • Alice Hamilton Award for Excellence in Occupational Safety and Health, 2006
  • CDC Charles C. Shepard Science Award; Honorable Mention for Outstanding Scientific Paper in Laboratory and Methods Category, 2006
  • Alice Hamilton Award for Excellence in Occupational Safety and Health, 2006
  • CDC Charles C. Shepard Science Award; Honorable Mention for Outstanding Scientific Paper in Laboratory and Methods Category, 2008

Honors And Special Scientific Recognition

  • Chair of Young Investigator Committee, Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia 1981-1989
  • Secretary of Russian-Indian Chapter, the International Society, Moscow, Russia 1989-1990
  • Member of Newsletter Committee, Allegheny-Erie Regional Chapter, SOT Member of Newsletter Committee, A-E Regional Chapter of SOT 1994-1995
  • President-Elect, Allegheny-Erie Regional Chapter of SOT 1997-1998
  • President of Allegheny-Erie Regional Chapter of SOT 1998-1999
  • Chair of Nomination Committee, Allegheny-Erie SOT 1999-2000
  • Coordinator for Summer Student Program, NIOSH/CDC 1998-current
  • Member of Placement Committee, the Society of Toxicology 1999-2001
  • Founder and Interim President of the Dermal Toxicology Specialty Section, SOT 1999-2000
  • President of the Dermal Toxicology Specialty Section, SOT 2000-2001
  • Who’s Who in America 1996-2000
  • American Women in Science 1998-1999
  • Member of New York Academy of Sciences 2001-current
  • Chairperson of Placement Committee, the Society of Toxicology 2001-2002
  • Fellow of the Academy of Toxicological Sciences 2001-current

Editorial/Manuscript Review Expirience (Past/Current)

  • Associate Editor, Toxicology and Applied Pharmacology 2008-current
  • Editorial Board of Toxicology and Applied Pharmacology 2003- 2007
  • Editorial Board of Regulatory Toxicology and Pharmacology 2004-2008
  • Reviewer for Journal Leukocyte Biology 1993-1996
  • Reviewer for Toxicological Sciences 1997-current
  • Reviewer for the Journal Industrial Toxicology 2002- current
  • Ad hoc Reviewer for Toxicology and Applied Pharmacology 2001- 2003
  • Editorial Board of Toxicology and Applied Pharmacology 2003- current
  • Reviewer for Chemical Research in Toxicology 2003- current
  • Reviewer for nutrition book “Body Stat,” Viking Penguin Press 1996
  • Reviewer In Vitro Toxicology 2004-current
  • Editorial Board of Toxicology & Apply Pharmacology Journal 2003-current

Additional Info

Professional Appointments

  • 1971-1972 Research Assistant, MV Lomonsov Moscow State University, Moscow
  • 1972-1978 Research Associate, Institute of Chemical Physics, USSR Academy of Sciences, Moscow
  • 1978-1984 Staff Research Scientist, Institute of Chemical Physics, USSR Academy of Sciences
  • 1984-1990 Team Leader, Institute of Chemical Physics, USSR Academy of Sciences
  • 1990-1991 Visiting Scholar, Department of Molecular and Cell Biology, University of California, Berkeley, CA 96804
  • 1991-1992 Pharmaceutical Consultant, Medicine Inc, Southampton, PA 18966
  • 1992-1995 Faculty, Center for Environmental and Occupational Health and Toxicology, University of Pittsburgh, Pittsburgh, PA 15238
  • 1995-1996 Manager, Nutrition Research, General Nutrition Corporation (GNC), Pittsburgh, PA 15222
  • 1996-1997 Research Assistant Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213
  • 1997-Present Senior Staff Scientist, National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, Health Effects Laboratory Division, Morgantown, WV 26505
  • 2001-Current Adjunct Professor of the Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV

Professional Societies

  • Society of Toxicology USA
  • American Association for Advancement in Science
  • International Society for Free Radical Research
  • New York academy of Sciences
  • Society for Investigative Dermatology

Additional Info

Specialties By Training Or Experience

Biology, human and animal physiology, membrane toxicology, occupational toxicology, particle/vapor toxicology, molecular and cellular toxicology, dermal and pulmonary toxicology, pathophysiology, physiology and biochemistry of vision, biochemistry and physiology of nutrition, lipid biophysics and biochemistry, free radical biology and medicine, inflammatory diseases, cardio- and cerebral vascular pathophysiology, risk assessment, effects of workplace exposures on human and animal body functions, preventive measures of exposures and control/intervention research.


Organizing And Chairing Meetings/Workshops

  • Toxicology in Court,” Allegheny-Erie Chapter, Society of Toxicology, Fall Meeting, October 28, 1997
  • Women Health Issue: Consideration to Toxicological Studies, Allegheny-Erie Chapter, Society of Toxicology, Spring Meeting, May 15, 1998
  • Paracelsus Goes to School- Science Teacher Workshops, Pittsburgh, PA, May 14, 1998; Cuyahoga Falls, OH, June 2, 1999; Pittsburgh, PA, May 16, 2000
  • Phenolic Compounds: Free Radical Mechanisms of Toxicity, Catalysis, and Protections, Symposium, Society of Toxicology 40th Annual Meeting, San Francisco, CA, March 29, 2001
  • How to Market Yourself as a Toxicologist, 41st Annual Society of Toxicology Meeting, March 18, 2002, Nashville, TN
  • 3rd International Conference on Oxygen/Nitrogen Radicals: Cell Injury and Disease, Morgantown, WV, June 1-5, 2002
  • Reactive Oxygen and Nitrogen Species: Diagnostic, Preventive, and Therapeutic Values, International Symposium,” Pre-Symposium to the XI-th Biennial Meeting of the Society for Free Radical Research International, St. Petersburg, Russia, July 9-13, 2002
  • Occupational Skin Exposure: Current Trends and Future Directions from the Field to Genomics, symposium, 43-rd Annual SOT Meeting, Baltimore, March 21-25, 2004
  • Toxicology Forum, February 2-4, 2004
  • 227th American Chemical Society National Meeting, March 28-April 1, 2004
  • 44th annual Society of Toxicology Meeting, March 6-11, New Orleans, CA 2005
  • 1st International Symposium, Nanotoxicology: Biomedical Aspects, Miami, FL 2006
  • Nobel Mini-Symposium on Nanotoxicology: Potential Risks and Safety Assessment, Stockholm, Sweden, November 27, 2006
  • Invited workgroup expert at “Predicting Nano-Bio Inter-actions” at the International Council on Nanotechnology (ICON) focused on the development of a framework for understanding the interactions between engineered nanoparticles and biological systems at the molecular level, Zurich, Switzerland, June 4-8, 2007

Interagency and Cooperative Agreements/Joint Research

  • Memorandum of Understanding NIOSH/NASA (2003-current)
  • NIOSH/FDA (2002-2005)
  • University of London/NIOSH, London, UK (2001-current)
  • EPA/NIOSH Toxic Substances Control Act (TSCA) review committee on Carbon Nanoparticles (2005)
  • University of Pittsburgh/NIOSH/EPA/NIEHS Nanotoxicology meeting (2006)
  • WVU/NIOSH/ NIEHS (2001-current)

Peer-Reviewer and Site Visit Evaluation

Expert review panel to evaluate the progress of a DOD Multi-Disciplinary University Initiative “Research between Physicochemical Characteristics and Toxicological Properties of Nanomaterials”, funded by Air Force Office of Scientific Research, Rochester, MN, October 12, 2006.

Research Program

Mechanism of chronic allergic skin and lung disease caused by industrial chemicals, vapor and particulates. Nanotoxicology. Free radical reactions and inflammatory cell responses, molecular regulation of oxidant, pro-inflammatory cytokine and growth fa...

Grants and Research

Teaching, Training And Developing Staff

  • Teaching and training six pre-doctoral students, 1983-1988.
  • Supervising and training five Ph.D. students and three post-doctoral fellows, 1984-90.
  • Training and supervising five associate researches and technicians, 1987-1989, 1993-97.
  • Teaching and coordinating summer student program at NIOSH/CDC and WVU/BRIN program 1998-2002.
  • Lecturing at West Virginia Science Teacher Association Meeting, 2001.
  • Supervising and training twenty college students from WVU and other universities at NIOSH 1997-2005.
  • Mentoring female students providing leadership and encouraging them to achieve their professional goals in health sciences and toxicology field (1997-current).
  • Supervising Ph.D. student – Ashley Murray, WVU, 2000-2006, WV, mentoring and training under-gradients, and gradient/rotation training students (1999-current).
  • Lecturing in occupational health course, WVU 2003-current.

Invited Presentations

  • Allegheny-Erie Regional Chapter, Society of Toxicology, Spring Meeting, Pittsburgh, PA, May 1998
  • International Conference on Chemistry of Organic Peroxides, Moscow, Russia, June 1998
  • Dermal Investigative Group Meeting, NIOSH/CDC, Cincinnati, OH, May 1999
  • International Contact Dermatitis Symposium, San Francisco, CA, October 1999
  • Manufacturing Technology and Consumable Product Division, Milacron, Cincinnati, OH, May 2000
  • Division of Life Science, King’s College, University of London, UK, August 2000
  • Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR, December 2000
  • Department of Physiology and Integrative Pharmacology, WVU, Morgantown, WV, February 2001
  • Society of Toxicology 40-th Annual Meeting, San Francisco, CA, March 2001
  • NanoSpace 2001: Exploring Interdisciplinary Frontiers. International Conference on Integrative Nano/Microtechnology for Space and Biomedical Applications, NASA, Galveston, TX, March 2001
  • Meijo University, Section of Radiochemistry, Faculty of Pharmaceutical Sciences, Nagoya, Japan, January 2002
  • NIOSH Ultrafine Aerosol Workshop, Wheeling, WV, Sept. 16 - 17, 2003
  • Institute Physico-Chemical Medicine, Moscow, Russia, Oct. 18-22, 2003
  • NASA/JSC-ES4/GBT, Houston, TX, Nov. 14-16, 2003
  • The Toxicology Forum's, 29th Toxicology Annual Winter Meeting Washington DC, February 2-4, 2004
  • International Congress of Nanomaterials 227th American Chemical Society Meeting, Symposium: Nanotechnology & the Environmental Toxicology & Bio-interactions of Nano-materials, March 28-April 1, 2004
  • Nanotoxicology Workshop, Gainsville, Fl. Nov 3 - 4 2004
  • International Congress on Nanotechnology, San Francisco, CA, Nov 7 - 10, 2004
  • National Nanonotechnology Infrastructure Network (NNIN): (Nanosafe: A workshop on Environmental Health and Safety in Nanotechnology Research), Atlanta, GA, Dec 1-3, 2004
  • 229th American Chemical Society National Meeting, San Diego, CA 2005, April 12-15
  • 2nd International Symposium on Nanotechnology and Occupational Health, Minneapolis, MN, October 3-6, 2005
  • ILSI Health and Environmental Science Institute: Nanomaterial Safety EHS Subcommittee, Washington, DC October 11, 2005
  • 8th International Meeting on Effects of Mineral Dusts and Nanoparticles, EPA, Triangle Park, NC, October 25 – October 28, 2005
  • 1st International Meeting: Nanotoxicology: Biomedical Aspects, Miami, FL, January 29 - February 1, 2006
  • Nobel Mini-Symposium on Nanotoxicology: Potential Risks and Safety Assessment, Karolinska Institute, Stockholm, Sweden, November 27, 2006
  • International Conference on Nanotechnology: Occupational and Environmental Health & Safety: Research to Practice, Cincinnati, OH, December 4-7, 2006
  • 2nd International Nanotoxicology Meeting, Venice, Italy, April 18-21, 2007
  • FASEB/ASPET, Experimental Biology Meeting, Washington, DC, April 30-May 2, 2007
  • ICON Workshop: “Towards Predicting Nano-Bio Interactions”, June 5 - 7, 2007, Zurich, Switzerland
  • 3rd NASA-NIST Workshop on Nanotube Measurements, NIST, Gaithersburgh, MD, USA, Sep 26-28, 2007
  • European NanOSH Conference –Nanotechnologies: A Critical Area in Occupational Safety and Health, Helsinki, Finland, 3–5 December 2007
  • Mary Babb Randolph Cancer Center – National Institute of Occupational Safety and Health MBRCC - NIOSH Scientific Retreat in Cancer, Morgantown, West Virginia, February 12, 2008
  • NATO workshop: Risk, Uncertainty and Decision Analysis for Nanomaterials: Environmental Risks and Benefits and Emerging Consumer Products, Portugal, Faro, April 26-30, 2008
  • American Thoracic Society (ATS), Toronto, May 16-21, 2008
  • Nanotoxicology 2nd International meeting, Switzerland, Zurich, September 7-10, 2008