Patrick S. Callery, PhD

Professor Emeritus

Organization:

West Virginia University School of Pharmacy

Department:

Pharmaceutical Sciences

Classification:

Faculty

Member

Organization:

West Virginia University WVU Cancer Institute

Department:

WVU Cancer Institute Research Programs

Classification:

Faculty

• PhD, University of California, San Francisco, 1974

Top 10 papers:

Spirochaete flagella hook proteins self-catalyse a lysinoalanine covalent crosslink for motility.
Miller MR, Miller KA, Bian J, James ME, Zhang S, Lynch MJ, Callery PS, Hettick JM, Cockburn A, Liu J, Li C, Crane BR, Charon NW.
Nat Microbiol. 2016 Aug 8;1(10):16134. doi: 10.1038/nmicrobiol.2016.134.
PMID: 27670115

Localized delivery of chemotherapy to the cervix for radiosensitization. 
Hodge LS, Downs LS Jr, Chura JC, Thomas SG, Callery PS, Soisson AP, Kramer P, Wolfe SS, Tracy TS. 
Gynecol Oncol. 2012 Oct;127(1):121-5. doi: 10.1016/j.ygyno.2012.07.097. Epub 2012 Jul 14.
PMID: 22796462

Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metabolite.
Peer CJ, Younis IR, Leonard SS, Gannett PM, Minarchick VC, Kenyon AJ, Rojanasakul Y, Callery PS.
Xenobiotica. 2012 Dec;42(12):1170-7. doi: 10.3109/00498254.2012.696740. Epub 2012 Jun 22.
PMID: 22725664

Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines.
Wichitnithad W, O'Callaghan JP, Miller DB, Train BC, Callery PS.
Bioorg Med Chem. 2011 Dec 15;19(24):7482-92. doi: 10.1016/j.bmc.2011.10.038. Epub 2011 Oct 21.
PMID: 22078410

Effects of different carboxylic ester spacers on chemical stability, release characteristics, and anticancer activity of mono-PEGylated curcumin conjugates.
Wichitnithad W, Nimmannit U, Callery PS, Rojsitthisak P.
J Pharm Sci. 2011 Dec;100(12):5206-18. doi: 10.1002/jps.22716. Epub 2011 Aug 17.
PMID: 21850703

Reversible and irreversible protein glutathionylation: biological and clinical aspects.
Cooper AJ, Pinto JT, Callery PS.
Expert Opin Drug Metab Toxicol. 2011 Jul;7(7):891-910. doi: 10.1517/17425255.2011.577738. Epub 2011 May 11. Review. Erratum in: Expert Opin Drug Metab Toxicol. 2011 Sep;7(9):1183.
PMID: 21557709

Identification of isobaric product ions in electrospray ionization mass spectra of fentanyl using multistage mass spectrometry and deuterium labeling.
Wichitnithad W, McManus TJ, Callery PS.
Rapid Commun Mass Spectrom. 2010 Sep 15;24(17):2547-53. doi: 10.1002/rcm.4673.
PMID: 20740529

Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents.
Cooper AJ, Krasnikov BF, Niatsetskaya ZV, Pinto JT, Callery PS, Villar MT, Artigues A, Bruschi SA.
Amino Acids. 2011 Jun;41(1):7-27. doi: 10.1007/s00726-010-0552-0. Epub 2010 Mar 22. Review.
PMID: 20306345

Trace evidence of trans-phenylpropene as a marker of smoked methamphetamine.
Shakleya DM, Plumley AE, Kraner JC, Bell SM, Callery PS.
J Anal Toxicol. 2008 Oct;32(8):705-8.
PMID: 19007525

Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1.
Younis IR, Elliott M, Peer CJ, Cooper AJ, Pinto JT, Konat GW, Kraszpulski M, Petros WP, Callery PS.
J Pharmacol Exp Ther. 2008 Dec;327(3):770-6. doi: 10.1124/jpet.108.142208. Epub 2008 Sep 12.
PMID: 18791061

1994-1997 - Science Advisor, Baltimore District Office, Food and Drug Administration
1994-pres. - Reviewer for National Institute on Drug Abuse SBIR, Contracts, and Concept Reviews
2003-2007 - Member, FDA Food Advisory Committee
2006 - Site visit team, Laboratory of Medicinal Chemistry, National Cancer Institute; Ad hoc reviewer, ZRG1 BCMB-A, Sharing Instrumentation Review Panel, National Institutes of Health
2007 - Ad hoc reviewer, ZRG1 BCMB-L, Drug Discovery and Development Special Emphasis Panel, National Institutes of Health
2007-pres - Editorial Board, Journal of Pharmaceutical and Biomedical Analysis
2008 - Ad Hoc reviewer, S10 mass spectrometers, National Institutes of Health; Ad hoc reviewer, F32 postdoctoral fellowships; Ad hoc reviewer, SBIR proposals, NIDA; Ad hoc reviewer, NIDA contracts
2009 - Reviewer: ZRG1 BCMB-H; ZRG1 IMST-G (11) B; ZRG1 IMST-B (30) I; ZRG1 IMM-E (58) R; SBIR proposals, NIDA; NIDA N44DA-9-8869 and N44DA-9-8874.
2010-pres. - Editorial Board, Journal of Analytical Toxicology
Patents
M.D. Loberg, P.S. Callery, and M. Cooper, New Pharmaceutical Chelates and Methods of External Imaging. U.S. Patent 4,017,596, 1977, plus foreign patents.  Marketed in U.S. by New England Nuclear and in  Canada by Merck Frosst.
P.S. Callery, J. Wright, N. Zenker, and C.S. Stone, Antihypertensive Benzoxazolones. U.S. Patent 4,034,100, 1977, plus foreign patents.  Assigned to Merck and Co.
P.S. Callery, J. Wright, and N. Zenker, Antihypertensive Benzimidazolones. U.S. Patent 4,073,929, 1977, plus foreign patents.  Assigned to Merck and Co.
P.S.Callery, M.J. Egorin, Y. Li, and Z.-M. Yuan, Diaziridinylpolyamine Anti-Cancer Agents. U.S. Patent 5,612,329, 1997.
T.S. Tracy, D.D. Glover, P.S. Callery, A.P. Soisson, and J.E. Smith, Cervical Isolation and Delivery Apparatus. U.S. Patent 7,165,550, 2007

Biosketch:

Education:

Post-doctoral Training- University of Maryland

Graduate Training - Ph.D., Pharmaceutical Chemistry, University of California San Francisco
Undergraduate Training - B.S., Pharmacy, University of Utah
 

Research Interests:

Anticancer drug discovery
 

Research Techniques

Mass spectrometry for structure elucidation and drug quantification. Drug discovery techniques emphasizing enzyme inhibition mechanism studies and identification of anticancer drug prototypes.

Patents

M.D. Loberg, P.S. Callery, and M. Cooper, New Pharmaceutical Chelates and Methods of External Imaging. U.S. Patent 4,017,596, 1977, plus foreign patents. Marketed in U.S. by New England Nuclear and in Canada by Merck Frosst.

Positions:

Assistant Professor, University of Maryland Baltimore, 1974-1978
Associate Professor, University of Maryland Baltimore, 1978-1990
Professor, University of Maryland Baltimore, 1990-1997
Adjunct Professor of Chemistry, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1993-
Professor and Chair, Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 1997-2009
Member, Mary Babb Randolph Cancer Center, 1997 -
Professor of Pharmaceutical Sciences,  2009 -
 

Teaching

Special Service

Member, Scientific Working Group on Forensic Toxicology
School of Pharmacy Class of 2014 advisor

Professional Memberships

Alexander B. Osborn Hematopoietic Malignancy and Transplantation Program

Anticancer agent, busulfan, is bioactivated by glutathione transferases to a reactive metabolite, EdAG.  We are investigating a linkage between EdAG formation and liver damage associated with HVOD.