Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases.
Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA.
PLoS One. 2017 Jan 5;12(1):e0169584. doi: 10.1371/journal.pone.0169584.PMID: 28056085
Vascular Complications in Living Donor Liver Transplantation at a high volume Centre: Evolving Protocols and Trends Observed over 10 years.
Shiraz AR, Nayeem MA, Agarwal S, Goyal N, Gupta S.
Liver Transpl. 2016 Nov 23. doi: 10.1002/lt.24682. [Epub ahead of print] PMID: 27880991
Vascular endothelial over-expression of soluble epoxide hydrolase (Tie2-sEH) enhances adenosine A1 receptor-dependent contraction in mouse mesenteric arteries: role of ATP-sensitive K+ channels.
Yadav VR, Hong KL, Zeldin DC, Nayeem MA. Mol Cell Biochem. 2016 Nov;422(1-2):197-206. PMID: 27629787
Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARγ.
Hanif A, Edin ML, Zeldin DC, Morisseau C, Nayeem MA. PLoS One. 2016 Sep 1;11(9):e0162147. doi: 10.1371/journal.pone.0162147. PMID: 27583776
Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARγ.
Hanif A, Edin ML, Zeldin DC, Morisseau C, Nayeem MA. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R676-R688. doi: 10.1152/ajpregu.00237.2016. PMID:27488890
Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors.
Yadav VR, Nayeem MA, Tilley SL, Mustafa SJ. Br J Pharmacol. 2015 Oct;172(20):4959-69. doi: 10.1111/bph.13265. PMID: 26227882
High salt diet modulates vascular response in A2AAR (+/+) and A 2AAR (-/-) mice: role of sEH, PPARγ, and K ATP channels.
Pradhan I, Ledent C, Mustafa SJ, Morisseau C, Nayeem MA. Mol Cell Biochem. 2015 Jun;404(1-2):87-96. doi: 10.1007/s11010-015-2368-4. PMID: 25739357
High salt diet exacerbates vascular contraction in the absence of adenosine A₂A receptor.
Pradhan I, Zeldin DC, Ledent C, Mustafa JS, Falck JR, Nayeem MA. J Cardiovasc Pharmacol. 2014 May;63(5):385-94. doi: 10.1097/FJC.0000000000000058. PMID: 24390173
Adenosine A1 receptor signaling inhibits BK channels through a PKCα-dependent mechanism in mouse aortic smooth muscle.
Kunduri S, Dick G, Nayeem M, Mustafa S. Physiol Rep. 2013 Sep 1;1(3). pii: e00037. PMID: 23977428
Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2.
Kunduri SS, Mustafa SJ, Ponnoth DS, Dick GM, Nayeem MA. J Cardiovasc Pharmacol. 2013 Jul;62(1):78-83. doi: 10.1097/FJC.0b013e3182919591. PMID: 23519140
About Mohammed Nayeem
Mohammed Nayeem, MSc, PhD., is an Assistant Professor in the Department of Pharmaceutical Sciences at West Virginia University, School of Pharmacy. Dr. Nayeem is serving as mentor and co-mentor to PhD. students, Postdoctoral Fellows, undergraduate students and lab technicians. Dr. Nayeem is the Principal Investigator (PI) in a currently funded NHLBI R01 grant (R01HL114559) entitled “Role of Cyp2j-epoxygenases, sEH and PPARs in adenosine-induced vascular response”. He was also a Co-Investigator in funded another NHLBI R01 grant (R01HL094447) entitled “Role of CYP P450s in the Regulation of Vascular Tone through Adenosine Receptors”. Further, he got scored as a Principal Investigator (PI) in another NHLBI Supplemental R01 grant (R01HL114559-03S1) entitled “Angiotensin II and the role of adenosine receptors, epoxygenases, sEH and PPARs with aging” (pending). Dr. Nayeem’s laboratory investigates the mechanism of vascular regulation involves hypertension, salt-sensitive hypertension and coronary reactive hyperemia in adult and aging mice using regular diet /special diet (low salt & high salt) in A2A AR-null, sEH-null, Tie-2-cyp2j2 Tr, Tie-2-sEH Tr and their respective wild-type mice. Dr. Nayeem’s long-term goal is to identify and develop novel pharmacological agents to target in preventing the progression of prehypertension to hypertension in humans who have allelic variants (genetic polymorphism) that may act similarly to our transgenic (A2A AR-null, sEH-null, Tie-2-cyp2j2 Tr, Tie-2-sEH Tr) mice in the regulation of vascular tone and blood pressure.
The identification of these signaling pathways will help to unravel the potential mechanism involving arachidonic acid and adenosine receptors in the vascular regulation of hypertension, salt-sensitive hypertension and coronary reactive hyperemia. Dr. Nayeem’s laboratory is one of the very few laboratories that have established a correlation between CYP450s, soluble epoxide hydrolase activities and adenosine receptors signaling. His laboratory is well prepared to undertake the proposed research, because his multidisciplinary research team has expertise as well as unique access to adenosine receptors, cyp-epoxygenases, soluble epoxide hydrolase, PPARα, PPARγ antibodies and specific soluble epoxide hydrolase inhibitor; A2A AR-null, sEH-null, Tie-2-cyp2j2 Tr, Tie-2-sEH Tr and their respective wild-type mice. Dr. Nayeem has been working in cardiovascular physiology & pharmacology, particularly in the field of Cyp450s and adenosine receptors for almost twelve years, including his training at NIEHS/NIH. He published many papers in peer-reviewed journals and presented work at national and international conferences in the field of cardiovascular Pharmacology.