F. Heath Damron , PhD

Associate Professor and Director of the Vaccine Development center WVU-Health Sciences Center

Organization:

West Virginia University School of Medicine

Department:

Microbiology, Immunology & Cell Biology

Classification:

Faculty

2022

1. Wong TY, Lee KS, Russ BP, Horspool AM, Kang J, Winters MT, Allison Wolf M, Rader NA, Miller OA, Shiflett M, Izac J, Varisco D, Sen-Kilic E, Cunningham C, Cooper M, Cyphert HA, Barbier M, Martinez I, Bevere JR, Ernst RK, Damron FH. Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge. NPJ vaccines. NPJ Vaccines; 2022 Dec 14;7(1):36. PMID: 35288576
2. Weaver KL, Blackwood CB, Horspool AM, Pyles GM, Sen-Kilic E, Grayson EM, Huckaby AB, Witt WT, DeJong MA, Wolf MA, Damron FH, Barbier M. Long-Term Analysis of Pertussis Vaccine Immunity to Identify Potential Markers of Vaccine-Induced Memory Associated With Whole Cell But Not Acellular Pertussis Immunization in Mice. Front Immunol. Front Immunol; 2022 Feb 8;13. PMID: 35211125
3. Wong TY, Horspool AM, Russ BP, Ye C, Lee KS, Winters MT, Bevere JR, Miller OA, Rader NA, Cooper M, Kieffer T, Sourimant J, Greninger A, Plemper RK, Denvir J, Cyphert HA, Barbier M, Torrelles JB, Martinez I, Martinez-Sobrido L, Damron FH. Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice. J Virol. J Virol; 2022 Jan 26;96(6). PMID: 35080423

2021

4. Hall JM, Bitzer GJ, DeJong MA, Kang J, Wong TY, Wolf MA, Bevere JR, Barbier M, Damron FH. Mucosal Immunization with DTaP Confers Protection against Bordetella pertussis Infection and Cough in Sprague-Dawley Rats. Infection and Immunity. 2021 Nov 16;89(12):e0034621. doi: 10.1128/IAI.00346-21. Epub 2021 Sep 13 PMID: 34516235
5. Horspool AM, Russ BP, Wolf MA, Kang J, Blackwood CB, Hall JM, Wong TY, DeJong MA, Bitzer G, Bevere JR, Eggleston R, Stewart A, Costello L, Welch S, Kieffer T, Hodder S, Damron FH. Serological survey of SARS-CoV-2 incidence conducted at a rural West Virginia hospital. medRxiv 2021 Aug 18;2021.08.16.21262128. doi: 10.1101/2021.08.16.21262128. Preprint
6. Hall JM, Kang J, Kenney SM, Wong TY, Bitzer GJ, Kelly CO, Kisamore CA, Boehm DT, DeJong MA, Wolf MA, Sen-Kilic E, Horspool AM, Bevere JR, Barbier M, Damron FH Reinvestigating the Coughing Rat Model of Pertussis To Understand Bordetella pertussis Pathogenesis. Infection and Immunity. 2021 Nov 16;89(12):e0030421. doi: 10.1128/IAI.00304-21. Epub 2021 Jun 14. PMID: 34125597
7. K.M. Edwards, M.D.Decker, F. Heath Damron Chapter 45 Pertussis Vaccines, Plotkin’s Vaccines 8^th Edition 2022
8. A. Horspool, T. Kieffer, B.Russ, M. DeJong, M. Wolf, J. Karakiozis, B. Hickey, P. Fagone, D. Tacker, J. R Bevere, I. Martinez, M. Barbier, P. Perrotta, F. H. Damron Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection mSphere  2021 Jan 20;6(1):e01324-20 PMID: 33472985
9. E. Sen-Kilic, C. Blackwood, A. Huckaby, A. Horspool, K. Weaver, A. Malkowski, W. Witt, J. Bevere, F.H. Damron, and Mariette Barbier Defining the mechanistic correlates of protection conferred by whole-cell vaccination against Pseudomonas aeruginosa acute murine pneumonia. Infection and Immunity 2021 Jan 19;89(2):e00451-20 PMID: 33199354
10. M Wolf, D. Boehm, M. A DeJong, T Wong, E. Sen-Kilic, J. M Hall, C. Blackwood, K. L Weaver, C. Kelly, C. Kisamore, G. Bitzer, J. Bevere, M. Barbier, F H. Damron Intranasal immunization with acellular pertussis vaccines results in long-term immunity to Bordetella pertussis in mice Infection and Immunity 2020 2020 Dec 14;IAI.00607-20 PMID: 33318136

• Article of Significant Interest of the Issue

2020

11. C. B. Blackwood, E. Sen-Kilic, D. T. Boehm, J. M. Hall, M. E. Varney, T. Y. Wong, S. D. Bradford, J. R Bevere, W. T. Witt, F. H. Damron, M. Barbier. Innate and Adaptive Immune Responses against Bordetella pertussis and Pseudomonas aeruginosa in a Murine Model of Mucosal Vaccination against Respiratory Infection. Vaccines (Basel) PMID: 33153066 DOI: 10.3390/vaccines8040647
12. F. H. Damron, M. Barbier, P. Dubey, K. M. Edwards, X. Gu, N. P. Klein, K. Lu, K. H. G. Mills, M. F. Pasetti, R. C. Read, P. Rohani, P. Sebo and E. T. Harvill, Overcoming Waning Immunity in Pertussis Vaccines: Workshop of the National Institute of Allergy and Infectious Diseases Journal of Immunology PMID: 32769142
13. C. Locht, N.H Carbonetti, J. D Cherry, F H. Damron, K. M Edwards, R.Fernandez, E.T Harvill, D. Hozbor, K. H G Mills, M. E. Rodriguez, F. Mascart, Highlights of the 12th International Bordetella Symposium, Clinical Infectious Diseases,  PMID: 32463883

 

2019

14. E. Sen-Kilic, C. B. Blackwood, D. T. Boehm, W. T. Witt, A. C. Malkowski, J. R. Bevere, T. Y. Wong, J. M. Hall, S. D. Bradford, M. E. Varney, F. H. Damron, M. Barbier.  Intranasal peptide-based FpvA-KLH conjugate vaccine protects mice from Pseudomonas aeruginosa acute murine pneumonia Frontiers in Immunology 2019; 10: 2497. Published online 2019 Oct 23. doi: 10.3389/fimmu.2019.02497 PMID: 31708925
15. D. T. Boehm, M. A. Wolf, J. M. Hall, T. Y. Wong, E. Sen-Kilic, H. D. Basinger, S.A. Dziadowicz, M. P. Gutierrez, C. B. Blackwood, S. D. Bradford, K. A. Begley, W. T. Witt, M. E. Varney, M. Barbier and F. H. Damron. Intranasal acellular pertussis vaccine provides mucosal immunity and protects mice from Bordetella pertussis Nature Vaccines volume 4, Article number: 40 (2019) PMID: 31602318
16. D. T. Boehm, M. E. Varney, T. Y. Wong, E. S. Nowak, E. Sen-Kilic, J. M. Hall, S. D. Bradford, K. A. Begley, J. U. Bevere, M. S. Epperly, J. A. Maynard, E. L. Hewlett, M. Barbier, F. H. Damron.  Characterizing the innate and adaptive responses of immunized mice to Bordetella pertussis infection using in vivo imaging and transcriptomic analysis.  https://www.biorxiv.org/content/10.1101/674408v2
17. T.Y. Wong, J.M. Hall, E. S. Nowak, D. T. Boehm, L. A. Gonyar, E. L. Hewlett, J. C. Eby, M. Barbier, and F. H. Damron. Analysis of the in vivo transcriptome of Bordetella pertussis during infection of mice. mSphere. 2019 Apr 17;4(2). pii: e00154-19. doi: 10.1128/mSphereDirect.00154-19.  PMID: 30996109
18. L.A. Gonyar, P.E. Gelbach, D.G. McDuffie, A.F. Koeppel, Q. Chen, G. Lee, L.M. Temple, S. Stibitz, E.L. Hewlett, J.A. Papin, F.H Damron, and J.C Eby In vivo gene essentiality and metabolism in Bordetella pertussis mSphere. 2019 May 22;4(3). pii: e00694-18. doi: 10.1128/mSphere.00694-18. PMID: 31118307
19. C.L. Hoffman, L.A. Gonyar, F. Zacca, F. Sisti, J. Fernandez, T. Wong, F.H. Damron, E. L. Hewlett EL4. Bordetella pertussis Can Be Motile and Express Flagellum-Like Structures MBio. 2019 May 14;10(3). pii: e00787-19. doi: 10.1128/mBio.00787-19. PMID: 31088927

2018

20. M.E. Varney, D.T. Boehm, K. DeRoos, E.S. Nowak, T.Y. Wong, E. Sen-Kilic, S.D. Bradford, C. Elkins, M.S. Epperly, W.T. Witt, M. A. Barbier and F. H. Damron. Bordetella pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naïve Infection by Driving Hematopoietic Stem and Progenitor Cell Expansion in Mice. Frontiers in Immunology 2018 vol: 9 pp:2376 PMID: 30405604
21. D.T. Boehm, J.M. Hall, T.Y. Wong, A. DiVenere, E. Sen-Kilic, J. R. Bevere, S. D. Bradford, C.B.Blackwood, C. Elkins, K. A. DeRoos, M.C. Gray, C. G. Cooper, M.E. Varney, J. A. Maynard, E. L. Hewlett, M. Barbier, and F.H.Damron. Evaluation of adenylate cyclase toxoid antigen in acellular pertussis vaccines using a Bordetella pertussis challenge model in mice. Infection and Immunity 2018 Sep 21;86(10). pii: e00857-17. doi: 10.1128/IAI.00857-17 PMID: 30012638
22. M.Barbier, J. Bevere, F.H.Damron.  Chapter 7: In Vivo Bacterial Imaging Using Bioluminescence. Methods in Molecular Biology Vol 1790 Reporter Gene Imaging
23. A.Little , Y. Okkotsu , A. Reinhart , F.H. Damron , M. Barbier , B. Barrett , A. G. Oglesby-Sherrouse , J. B.Goldberg, W. L Cody , M. Schurr , M. L. Vasil, M. J. Schurr.  Pseudomonas aeruginosa AlgR Phosphorylation Status Differentially Regulates Pyocyanin and Pyoverdine production. MBio 2018 Jan 30;9(1). pii: e02318-17. doi: 10.1128/mBio.02318-17 PMID: 29382736

2017

24. A. Reinhart, A. T. Nguyen, L. K. Brewer, J. Bevere, J. W. Jones, M. A. Kane, F. H. Damron, M. Barbier and A. G. Oglesby-Sherrouse. The Pseudomonas aeruginosa PrrF Small RNAs Regulate Iron Homeostasis During Acute Murine Lung Infection. Infection and Immunity. 2017 Apr 21;85(5). pii: e00764-16. doi: 10.1128/IAI.00764-16.  PMID: 28289146  
25. T. Wong, J. Hall, D. Boehm, M. Barbier, F. H. Damron. Development Of RNAseq Methodologies To Profile The In Vivo Transcriptome Of Bordetella pertussis During Murine Lung Infection bioRxiv 140632; doi: https://doi.org/10.1101/140632

2016

26. F. H. Damron, A. Oglesby-Sherrouse, A. Wilks, M. Barbier.  Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia.  Scientific Reports 2016 Dec 16;6:39172 PMID: 27982111
27. M. Barbier, D.T. Boehm, E. Sen-Kilic, C. Bonnin, T. Pinheiro, C. Hoffman, M. Gray, E. Hewlett, F.H. Damron Modulation of pertussis and adenylate cyclase toxins by sigma factor RpoE in Bordetella pertussis. Infection and Immunity 2016 Dec 29;85(1) PMID: 27849178
28. C. Hoffman, J. Eby, M. Gray F. H. Damron, P. Cotter, E. Hewlett. Bordetella adenylate cyclase toxin interacts with filamentous hemagglutinin to inhibit biofilm formation in vitro. Mol Microbiol. 2016 Oct 12. PMID: 27731909
29. M. Barbier M, F. H. Damron. Rainbow Vectors for Broad-Range Bacterial Fluorescence Labeling. PLoS One. 2016 Mar 3;11(3):e0146827. doi: 10.1371/journal.pone.0146827. eCollection 2016. PubMed PMID: 26937640; PubMed Central PMCID: PMC4777285

 

2015

30. Varga J., Barbier M., Mulet X, Bielecki P, Bartell J, Owings J, Martinez-Ramos I, Hittle L, Davis MR Jr, Damron F.H., Liechti G, Puchałka J, Dos Santos V, Ernst R, Papin J, Albertí S, Oliver A, Goldberg J. Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains. BMC Genomics 2015 Oct 30; 16(1):883 PMID 26519161
31. J. Dai, H. Wei, C. Tian, F. H. Damron, J. Zhou, D. Qiu. An extracytoplasmic function sigma factor-dependent periplasmic glutathione peroxidase is involved in oxidative stress response of Shewanella oneidensis.  BMC Microbiology 2015 Feb 18;15(1):34. doi: 10.1186/s12866-015-0357-0. 25887418. PMID 25887418
2014.  
32. M. Barbier*, F.H. Damron, P. Bielecki, M. Suárez-Diez, J. Puchałka, S. Albertí, V. dos Santos, J. B. Goldberg.  From the environment to the host: re-wiring of the transcriptome of Pseudomonas aeruginosa from 22°C to 37°C PLOS ONE 9(2): e89941. doi:10.1371/journal.pone.0089941 * M.B. and F.H.D contributed equally to this publication. PMID 24587139
2013.  
33. F.H. Damron* and M. Barbier* Predatory bacteria: Living Antibiotics, Biocontrol Agents, or Probiotics? Journal of Postdoctoral Research Dec. 2013 * M.B. and F.H.D contributed equally to this publication. Link to article - http://dx.doi.org/qnz
34. M. Barbier* and F.H. Damron.* A Recipe for a Successful Postdoctoral Research Symposium. Journal of Postdoctoral Affairs Link to article * M.B. and F.H.D contributed equally to this publication
35. Y. Yin, F. H. Damron, T. R. Withers, C. L. Pritchett, X. Wang, M. J. Schurr and H. D. Yu.  Expression of mucoid induction factor MucE is dependent upon the alternate sigma factor AlgU in Pseudomonas aeruginosa BMC Microbiology 13:232. PMID 24138584
36. F. H. Damron, M. Barbier, E. S. McKenney, M. J. Schurr and J. B. Goldberg. Genes Required for and Effects of Inducible Alginate Overproduction by Growth of Pseudomonas aeruginosa on PIAAMV. Journal of Bacteriology 195:4020-4036. PMID 23794622      
    1. Cover art: The image was selected from this publication and featured on the cover of the Journal of Bacteriology in August 2013
37. M. Barbier, J. P. Owings, I. Martinez-Ramos, F. H. Damron, R. Gomila, J. Blazquez, J. B. Goldberg, and S. Alberti. 2013. Lysine Trimethylation of EF-Tu Mimics Platelet-Activating Factor To Initiate Pseudomonas aeruginosa Pneumonia. MBio 4. PMID 23653444
    1. Highlighted on mBio sphere:  Protein as spork: Opportunistic pathogen uses 1 protein in 2 ways
    2. Highlighted on Science Daily: Pathogen Turns Protein Into a Virulence Factor in One Easy Step
38. F. H. Damron, E. S. McKenney, M. Barbier, G. W. Liechti, H. P. Schweizer, and J. B. Goldberg. 2013. Construction of Mobilizable Mini-Tn7 Vectors for Bioluminescent Detection of Gram-Negative Bacteria and Single-Copy Promoter lux Reporter Analysis. Applied Environmental Microbiology 79:4149-53. PMID 23584769
    1. Cover art: This image was featured on the cover of AEM 2013.
39. T.R. Withers, F. H. Damron, Y. Yin, H. Yu.  Truncation of type IV pilin induces mucoidy in Pseudomonas aeruginosa strain PAO579. 2013.  Microbiology Open 2:459-70. PMID 23533140
40. F. H. Damron, E. McKenney, H. P. Schweizer, J.B. Goldberg. 2013. Construction of a Broad-Host-Range Tn7-Based Vector for Single-Copy PBAD-Controlled Gene Expression in Gram-Negative Bacteria. Applied Environmental Microbiology 79: 718-721. PMID 23124231

 

2012.  

41. F. H. Damron and J. B. Goldberg. 2012. Proteolytic regulation of alginate overproduction in Pseudomonas aeruginosa. Molecular Microbiology 84:595-607.  PMID 22497280
42. F. H. Damron, J. P. Owings, Y. Okkotsu, J. J. Varga, J. R. Schurr, J. B. Goldberg, M. J. Schurr and H. D. Yu. 2012. Analysis of the Pseudomonas aeruginosa Regulon Controlled by the Sensor Kinase KinB and Sigma Factor RpoN. Journal of Bacteriology 194: 1317-1330. PMID 22210761
2011.  
43. J. Rao*, F. H. Damron*, M. Basler,  A. DiGiandomenico, N. E. Sherman, J.W. Fox, J. Mekalanos, and J. B. Goldberg. 2011. Proteomic analysis of nonmucoid and mucoid Pseudomonas aeruginosa clinical isolates from a cystic fibrosis patient. Frontiers in Cellular and Infection Microbiology. 2: 162 *J.R. and F.H.D contributed equally to this publication. PMID 21863142
44. F. H. Damron, M. R. Davis Jr., T. R. Withers, R. K. Ernst, J. B. Goldberg, G. Yu, and H. D. Yu. 2011. Vanadate and triclosan synergistically induce alginate overproduction by Pseudomonas aeruginosa strain PAO1.  Molecular Microbiology. 81: 554-570. PMID 21631603
    1. “Cystic Fibrosis - Study Findings from F.H. Damron et al. Broaden Understanding of Cystic Fibrosis” Life Science Weekly
45. F. H. Damron and H.D. Yu. 2011. Pseudomonas aeruginosa MucD regulates alginate pathway through activation of MucA degradation via MucP proteolytic activity. Journal of Bacteriology. 193, 286-291. PMID 21036998

2009

46. F. H. Damron, J.Napper, M.A. Teter and H.D. Yu.  2009. Lipotoxin F of Pseudomonas aeruginosa is an AlgU-dependent and alginate-independent outer membrane protein involved in resistance to oxidative stress and adhesion to A549 human lung epithelia Microbiology 155, 1028 - 1038.  PMID 19332805
47. F. H. Damron, D. Qiu and H.D. Yu. 2009. The Pseudomonas aeruginosa sensor kinase KinB negatively controls alginate production through AlgW-dependent MucA proteolysis. Journal of Bacteriology 191, 2285-2295. PMID 19168621

2008

48. D. Qiu*, F. H. Damron*, T.Mima, H.P. Schweizer, H.D. Yu. 2008. PBAD-Based shuttle vectors for functional analysis of toxic and highly regulated genes in Pseudomonas and Burkholderia spp. and other bacteria.  Applied Environmental Microbiology. 74:7422-7426.* D.Q. and F.H.D contributed equally to this publication.  PMID 18849445  
    1. Link to Google Scholar citations.