- West Virginia University School of Medicine
- Human Performance - Exercise Physiology
Program 2: Breast Cancer
- BS, Loma Linda University, CA, 1993
- PhD, Loma Linda University, CA, 2000
Ten Most Recent:
High-fat, high-calorie diet enhances mammary carcinogenesis and local inflammation in MMTV-PyMT mouse model of breast cancer.
Cowen S, McLaughlin SL, Hobbs GR, Coad JE, Martin KH, Olfert IM, Vona-Davis LC.
Cancers (Basel). 2015;7(3):1125-1142.
Improved arterial-ventricular coupling in metabolic syndrome after exercise training: a pilot study.
Fournier SB, Donley DA, Bonner DE, Devallance E, Olfert IM, Chantler PD.
Med Sci Sports Exerc. 2015;47(1):2-11.
Muscle-derived vascular endothelial growth factor regulates microvascular remodelling in response to increased shear stress in mice.
Uchida C, Nwadozi E, Hasanee A, Olenich S, Olfert IM, Haas TL.
Acta Physiol (Oxf). 2015;214(3):349-360.
Loss of adipocyte VEGF impairs endurance exercise capacity in mice.
Zachwieja NJ, O'Connell GC, Stricker JC, Allen J, Vona-Davis LC, Bryner R, Mandler W, Olfert IM.
Med Sci Sports Exerc. 2015;47(11):2329-2339.
Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart.
Croston TL, Thapa D, Holden AA, Tveter KJ, Lewis SE, Shepherd DL, Nichols CE, Long DM, Olfert IM, Jagannathan R, Hollander JM.
Am J Physiol Heart Circ Physiol. 2014;307(1):H54-H65.
Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity.
Darquenne C, Borja MG, Oakes JM, Breen EC, Olfert IM, Scadeng M, Prisk GK.
J Appl Physiol (1985). 2014;117(8):880-886.
Aerobic exercise training reduces arterial stiffness in metabolic syndrome.
Donley DA, Fournier SB, Reger BL, Devallance E, Bonner DE, Olfert IM, Frisbee JC, Chantler PD.
J Appl Physiol (1985). 2014;116(11):1396-1404.
Exercise reveals impairments in left ventricular systolic function in patients with metabolic syndrome.
Fournier SB, Reger BL, Donley DA, Bonner DE, Warden BE, Gharib W, Failinger CF, Olfert MD, Frisbee JC, Olfert IM, Chantler PD.
Exp Physiol. 2014;99(1):149-163.
Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats.
Frisbee JC, Goodwill AG, Frisbee SJ, Butcher JT, Brock RW, Olfert IM, DeVallance ER, Chantler PD.
Am J Physiol Heart Circ Physiol. 2014;307(12):H1714-H1728.
Angiotensin II evokes angiogenic signals within skeletal muscle through co-ordinated effects on skeletal myocytes and endothelial cells.
Gorman JL, Liu ST, Slopack D, Shariati K, Hasanee A, Olenich S, Olfert IM, Haas TL.
PLoS One. 2014;9(1):e85537
HONORS & AWARDS
1991, Lambda Beta National Honor Society
1992, Walla Walla County Outstanding Emergency Medical Services Recognition
1994, Loma Linda University Student Research Award
1999, Poctor & Gamble Professional Opportunity Award, American Physiological Society (EEP Section)
2000, Gatorade Young Investigator Award, American Physiological Society (EEP Section)
2000, Carl Gisolfi Student Award in Exercise Science, APS Integrative Biology of Exercise
2005-08, Parker B. Francis Fellowship Award
2005-08, TRDRP New Investigator Award
2009, American Physiological Society Research Career Enhancement Award
2011, American College of Sports Medicine Visiting Scholar Award
About I. Mark Olfert
2016- Current Director, Clinical & Translational Sciences PhD Graduate Program. West Virginia University School of Medicine, Robert C. Byrd Health Science Center.
2015 - Current Associate Professor (tenured), Division of Exercise Physiology, West Virginia University School of Medicine, Robert C. Byrd Health Science Center, Morgantown, WV 26506 (effective 7/1/2015
2009 - 2015 Assistant Professor (tenure-track), Division of Exercise Physiology, West Virginia University School of Medicine, Robert C. Byrd Health Science Center, Morgantown, WV 26506
2006 - 2009 Adjunct Assistant Professor of Medicine, Division of Physiology, Department of Medicine, University of California-San Diego, La Jolla, CA 92093
2003 - 2005 Assistant Project Physiologist, Division of Physiology, Department of Medicine, University of California-San Diego, La Jolla, CA 92093
2001 - 2003 Postdoctoral Fellow, Division of Physiology, Department of Medicine, University of California-San Diego, La Jolla, CA 92093
1994 - 1997 Clinical Instructor, Dept. of Cardiopulmonary Science, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92354
1993 Pulmonary Research Specialist, Dept. of Preventive Medicine, School of Public Health and School of Medicine, Loma Linda University, Loma Linda, CA 92354
American Physiological Society (APS)
American College of Sports Medicine (ACSM)
International Society of Mountain Medicine (ISMM)
Review Boards & Committees
2001-2003, Trainee Representative, Steering/Program Committee EEP Section American Physiological Society
2007-2008, Ireland Health Research Board (Ad hoc)
2009-2010, AHA Study Group Member (R4–Cell Transport, Physiology & Metabolism)
2009, Fondazione per la Ricerca Scientifica Termale (FoRST), Italy (Ad hoc)
2011, NIH (NHLBI) Special Emphasis Panel ZHL1 (Ad hoc)
2013-2015 Veterans Health Administration, RRD2 & 5 Study Section (Ad hoc)
2014-current, Crew Cardiovascular Health, Study Section (Ad hoc)
2014-current, American Heart Association, National Affiliate, Lung Basic Science 2 (member)
2015-current, Veterans Health Administration, RRD5 Study Section (member)
Frontiers in Physiology, Review Editor for Specialty Section for Frontiers in Exercise Physiology, 2012-
Sport Sciences for Heath Journal, 2012-2016
Journal of Applied Physiology, 2012-2015
My laboratory conducts research in cardiopulmonary and skeletal muscle physiology as it pertains to health and disease. My research covers two broad areas, 1) pulmonary gas exchange and ventilation under conditions of stress (e.g. disease, exercise, high altitude) and 2) factors limiting O2 transport and exercise capacity, particularly in context of the formation and/or remodeling of skeletal muscle microvessels (i.e. angiogenesis) in chronic diseases, such as chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), renal failure, and/or diabetes.
The current major focus in my laboratory is to better understand the molecular regulation of skeletal muscle angiogenesis. One factor of particular interest is vascular endothelial growth factor (VEGF), which is a critical factor for vessel formation during growth and development, but is also found to be important throughout life (e.g. in response to wound healing, tumor progression, and exercise-induced skeletal muscle angiogenesis). Recent discoveries in my laboratory have also expanded our interest in the role of negative angiogenic regulators and extracellular matrix proteins, such as thrombospondin (TSP) and matrix metalloproteinases (MMPs), may play in pathophysiology of cardiac and skeletal muscle co-morbidities associated with COPD and other chronic diseases.
Students working in my laboratory can expect to learn and use a multidisciplinary approach in involving cellular and molecular, histochemical, biochemical, and classical physiologic techniques in the study of human and animal (i.e. transgenic) models. These studies take a translational approach to better understand the pathophysiology of cardiac and skeletal muscle dysfunction in association chronic cardiac, respiratory and/or metabolic disease.
Grants and Research
EXTRAMURAL GRANTS & FUNDING
2014-2015, WVCTI Obesity/Metabolic Disease Pilot project grant NIH/NIGMS
U54GM104942 (PI: Olfert $50K)
2014-2014, WVU Research Corporation: Program to Stimulate Competitive Research
(PSCoR)(PI: Olfert $25K)
2012-2013, American Cancer Society / Mary Babb Randolph Cancer Center (ACS-IRG)
Award (PI: Olfert $30,000)
2012-2012, WVU Research Funding and Development Grant (PI: Olfert, $25,000)
2009-2011, American Heart Association (Great Rivers Affiliate), Beginning Grant-in-Aid
2006-2008, NIH Clinical Research LRP Award (PI, $21,948)
2006-2010, NIH R01 #HL080203 (Co-investigator)
2005-2008, Tobacco Related Disease Research Program, New Investigator Award
2005-2009, NASA / National Space Biomedical Research Institute (co-investigator)
2005-2008, Parker B. Francis Fellowship Award in Pulmonary Research (PI, $132,000)
2004-2006, NIH Clinical Research LRP Award (PI, $54,200)
2003-2005, American Heart Association (Western States Affiliate), Beginning Grant-in-Aid
Patient Care Information
Fellowship, Division of Physiology, School of Medicine
University of California San Diego, La Jolla, CA, 2003
Other Speciality Training, Registered Respiratory Therapist
Other Speciality Training, Certified Pulmonary Function Technician
Other Speciality Training, Physiological Training Course (with Chamber Flight to FL250 and Rapid Decompression)
NASA Johnson Space Center, 2006