- Ophthalmology and Visual Sciences
- Adjunct Faculty
- Rockefeller Neuroscience Institute
- PhD, Weimann Institute of Science, Rehovot, Israel
- Wright ZC, SIngh RK, Alpino R, Goldberg AF, Sokolov M, Ramamurthy V. ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment. Hum Mol Genet (2016) [Epub ahead of print].
- Sinha S, Belcastro M, Datta P, Seo S, Sokolov M. Essential role of the chaperonin CCT in rod outer segment biogenesis. Invest Ophthalmol Vis Sci (2014) 55(6): 3775-85. PMCID: PMC4062400.
- Gao X, Sinha S, Belcastro M, Woodard C, Ramamurthy V, Stoilov P, Sokolov M. Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins. J Biol Chem (2013 Sep 6); 288(36):25760-8.
- Sinha S, Majumder A, Belcastro M, Sokolov M, Artemyev NO. Expression and subcellular distribution of UNC119a, a protein partner of transducin α subunit in rod photoreceptors. Cell Signal (2013 Jan) 25(1): 341-8. doi: 10.1016/j.cellsig.2012.10.005.
- Belcastro M, Song H, Sinha S, Song C, Mathers PH, Sokolov M. Phosphorylation of phosducin accelerates rod recovery from transducin translocation. Invest Ophthalmol Vis Sci (2012 May 1) 53(6): 3084-91. doi: 10.1167/iovs.11-8798.
- Yang J, Wang L, Song H, Sokolov M. Current understanding of usher syndrome type II. Front Biosci (2012 Jan 1) 17:1165-83.
- Posokhova E, Song H, Belcastro M, Higgins L, Bigley LR, Michaud NA, Martemyanov KA, Sokolov M. Disruption of the chaperonin containing TCP-1 function affects protein networks essential for Rod outer segment morphogenesis and survival. Mol Cell Proteomics. 2010 Sep 17.
- Edrington TC, Sokolov M, Boesze-Battaglia K. Peripherin/rds co-distributes with putative binding partners in basal rod outer segment disks. Exp Eye Res (2011) 92(5):439-42.
This laboratory studies biochemistry and cell biology of photoreceptors, sensory neurons of the retina responsible for acquisition of visual information. Our primary research interest is to elucidate molecular and cellular functions of chaperonin CCT/TRiC in neurons using mouse photoreceptors as a model. Our long-term goal is to explore the link between the protein-folding activity of CCT/TRiC complex and pathological neurodegenerative processes in the retina and brain caused by perturbation of protein homeostasis. In our studies we utilize variety of techniques including transgenic gene manipulation, global and targeted analyses of genes and proteins expression, and fluorescent microscopy. Our vision research laboratories are located on the 3d floor of WVU Eye Institute. We accept and train students from the Neuroscience and Biochemistry and Molecular Biology graduate programs.