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Vincent  Castranova

Vincent Castranova PhD

Adjunct Professor, Department of Basic Pharmaceutical Sciences, School of Pharmacy, WVU

PO Box 9300
Morgantown, West Virginia 26505

Program 5: Sara Crile Allen and James Frederick Allen Lung Cancer (Emerging)

Cancer Center Research Programs



West Virginia University, PhD


Long Bio

Dr. Castranova is the former chief of the Pathology and Physiology Research Branch, NIOSH Health Effects Laboratory Division, in Morgantown. He is also an adjunct professor in the Department of Department of Basic Pharmaceutical Sciences, West Virginia University, and the Department of Environmental and Occupational Medicine, University of Pittsburgh. He holds a Ph.D. degree in physiology and biophysics from West Virginia University.


Ten Most Recent:

Interlaboratory evaluation of rodent pulmonary responses to engineered nanomaterials: The NIEHS NanoGo Consortium.
Bonner JC, Silva RM, Taylor AJ, Brown JM, Hilderbrand SC, Castranova V, Porter DW, Elder A, Oberdorster G, Harkema JR, Bramble LA, Kavanagh TJ, Botta D, Nel AE, Pinkerton KE.
Environ Health Perspect. 2013;121(6):676-682.

Nanotechnology: toxicologic pathology.
Hubbs AF, Sargent LM, Porter DW, Sager TM, Chen BT, Frazer DG, Castranova V, Sriram K, Nurkiewicz TR, Reynolds SH, Battelli LA, Schwegler-Berry D, McKinney W, Fluharty KL, Mercer RR.
Toxicol Pathol. 2013;4(2):395-409.

The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.
Pacurari M, Addison JB, Bondalapati N, Wan YW, Luo D, Qian Y, Castranova V, Ivanov AV, Guo NL.
Int J Oncol. 2013;

Differential mouse pulmonary dose- and time course-responses to titanium dioxide nanospheres and nanobelts.
Porter DW, Wu NQ, Hubbs AF, Mercer R, Funk K, Meng F, Li J, Wolfarth M, Battelli L, Friend S, Andrew ME, Hamilton R, Sriram K, Yang F, Castranova V, Holian A.
Toxicol Sci. 2013;131(1):179-193.


Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats.
Roberts JR, Antonini JM, Porter DW, Chapman RS, Scabilloni JF, Young SH, Schwegler-Berry D,Castranova V, Mercer RR.
Part Fibre Toxicol. 2013;10:5


Titanium dioxide nanoparticles: a review of current toxicological data.
Shi H, Magaye R, Castranova V, Zhao J.
Part Fibre Toxicol. 2013;10(1):15

Systematic analysis of multiwalled carbon nanotube-induced cellular signaling and gene expression in human small airway epithelial cells.
Snyder-Talkington BN, Pacurari M, Dong C, Leonard SS, Schwegler-Berry D, Castranova V, Qian Y, Guo NL.
Toxicol Sci. 2013;133(1):79-89.


Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.
Tkach AV, Yanamala N, Stanley S, Shurin MR, Shurin GV, Kisin ER, Murray AR, Pareso S, Khaliullin T, Kotchey GP, Castranova V, Mathur S, Fadeel B, Star A, Kagan VE, Shvedova AA.
Small. 2013;9(9-10):1686-1690.

Neoplastic-like transformation effect of single-walled and multi-walled-carbon nanotubes compared to asbestos on human lung small airway epithelial cells.
Wang LY, Stueckle TA, Mishra A, Derk R, Meighan T, Castranova V, Rojanasakul Y.
Nanotoxicology. 2013; [Epub ahead of print]

Apoptosis induced by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS generation through both extrinsic and intrinsic apoptosis pathways.
Zhao J, Bowman L, Magaye R, Leonard SS, Castranova V, Ding M.
Int J Oncol. 2013;42(4):1349-1359.

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