David Rasicci, PhD

Assistant Professor, Department of Pathology, Anatomy & Laboratory Medicine

Organization:

West Virginia University School of Medicine

Department:

Pathology, Anatomy and Laboratory Medicine

Classification:

Faculty

• PhD, Pennsylvania State University, College of Medicine, 2022
• MS, Colorado State University, 2018
• BS, University of California, Santa Barbara, 2011

1. Rasicci DV, Kirkland O, Moonschi FH, Wood NB, Szczesna-Cordary D, Previs MJ, Wenk JF, Campbell KS, and Yengo CM. Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin. J Gen Physiol 153: 2021. 10.1085/jgp.202012811

2. Mahmud Z, Tikunova S, Belevych N, Wagg CS, Zhabyeyev P, Liu PB, Rasicci DV, Yengo CM, Oudit GY, Lopaschuk GD, Reiser PJ, Davis JP, and Hwang PM. Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction. Front Physiol 13: 892979, 2022. 10.3389/fphys.2022.892979

3. Touma AM, Tang W, Rasicci DV, Vang D, Rai A, Previs SB, Warshaw DM, Yengo CM, and Sivaramakrishnan S. Nanosurfer assay dissects β-cardiac myosin and cardiac myosin-binding protein C interactions. Biophys J 121: 2449-2460, 2022. 10.1016/j.bpj.2022.05.013

4. Rasicci DV, Tiwari P, Bodt SML, Desetty R, Sadler FR, Sivaramakrishnan S, Craig R, and Yengo CM. Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin. Elife 11: 2022. 10.7554/eLife.77415

5. Doran MH, Rynkiewicz MJ, Pavadai E, Bodt SML, Rasicci DV, Moore JR, Yengo CM, Bullitt E, and Lehman W. Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. J Gen Physiol 155: 2023. 10.1085/jgp.202213274