Shailendra Singh, MD, FASGE

Professor & Director of Advanced Therapeutic Endoscopy
Director of Bariatric Endoscopy

Organization:

West Virginia University School of Medicine

Department:

Medicine

Classification:

Faculty

• MD, Maulana Azad Medical College, Delhi University, India, 2009

Singh S, Bilal M, Pakhchanian H, Raiker R, Kochhar GS, Thompson CC. Impact of Obesity on Outcomes of Patients With Coronavirus Disease 2019 in the United States: A Multicenter Electronic Health Records Network Study. Gastroenterology. 2020; 159(6) :2221-2225. doi:10.1053/j.gastro.2020.08.028 PMID: 32835663.

Singh S, Khan A. Clinical Characteristics and Outcomes of Coronavirus Disease 2019 Among Patients With Preexisting Liver Disease in the United States: A Multicenter Research Network Study. Gastroenterology. 2020 Aug;159(2):768-771.e3. doi: 10.1053/j.gastro.2020.04.064. Epub 2020 May 4. PMID: 32376408.

Singh S, Khan, A, Chowdhry M, Bilal M, Kochhar G, Clarke, K. Risk of Severe COVID-19 in Patients with Inflammatory Bowel Disease in United States. A Multicenter Research Network Study. Gastroenterology. 2020 Oct; 159(4) :1575-1578.e4 PMID: 32522507. doi.org/10.1053/j.gastro.2020.06.003.

Holzwanger EA, Bilal M, Glissen Brown JR, Singh S, Becq A, Ernest-Suarez K, Berzin TM. Benchmarking False Positive Definitions for Computer Aided Polyp Detection in Colonoscopy. Endoscopy. 2020 Nov 2. doi: 10.1055/a-1302-2942. Epub ahead of print. PMID: 33137833.

Chowdhry M, Haden D, Kemper S, Helmick K, Kawsara M, Huggett A, Stark A, Khan A, Shah M, Bhaty M, Farooq J, Singh S, McJunkin B. Usual opioid dosing does not adversely affect the course of healthcare-associated Clostridioides difficile infection. Pain Manag. 2020 Dec 22. doi: 10.2217/pmt-2020-0066. Epub ahead of print. PMID: 33350354.

Feuerstein JD, Bilal M, Berzin TM, Calderwood AH, Guturu P, Juncadella AC, Ketwaroo G, Mishkin D, Perdue DG, Sekhon S, Sengupta N, Singh S, Pleskow DK, Sawhney MS. Triage of General Gastrointestinal Endoscopic Procedures During the COVID-19 Pandemic: Results from a National Delphi Consensus Panel. Techniques and Innovations in Gastrointestinal Endoscopy. 2020. doi.org/10.1016/j.tige.2020.12.005.

S Singh, AN Bazarbashi, A Khan et al. Primary Obesity Surgery Endoluminal (POSE) for the Treatment of Obesity: A Systematic Review and Meta-analysis. Accepted for publication. Surgical Endoscopy.

Khan A, Gupta K, Chowdhry M, Maheshwari S, Patel C, Pervez H, Bilal M, Khan MA, Singh S. Thirty-Day Readmission Rates, Reasons, and Costs after Index Hospitalizations for Gastrointestinal Angiodysplasia related bleeding in the United States. Accepted for publication. European Journal of Gastroenterology & Hepatology.

Pakhchanian H, Raiker R, Mukherjee A, Khan A, Singh S, Chatterjee A. Outcomes of COVID-19 in Chronic Kidney Disease Patients. Accepted for Publication. Clinical Journal of the American Society of Nephrology.

Saurabh Chandan, Khan S, Babu PM, Bilal M, S Singh et al. Endoscopic ultrasound guided gastroenterostomy (EUS-GE) versus enteral stenting (ES) for gastric outlet obstruction (GOO) – A systematic review and meta-analysis of 659 patients. Accepted for publication Endoscopy International Open.

Khan A, Maheshwari S, Gupta K, Naseem K, Chowdry M, Singh S. Rate, reasons, predictors, and burden of readmissions after transjugular intrahepatic portosystemic shunt placement. J Gastroenterol Hepatol. 2020 Jul 25. doi: 10.1111/jgh.15194. Epub ahead of print. PMID: 32710679.

Singh S, de Moura DTH, Khan A, Bilal M, Chowdhry M, Ryan MB, Bazarbashi AN, Thompson CC. Intragastric Balloon Versus Endoscopic Sleeve Gastroplasty for the Treatment of Obesity: a Systematic Review and Meta-analysis. Obes Surg. 2020 Aug;30(8):3010-3029. doi: 10.1007/s11695-020-04644-8. PMID: 32399847.

Bilal M, Samuel R, Khalil MK, Singh S, Parupudi S, Abougergi MS. Nonvariceal upper GI hemorrhage after percutaneous coronary intervention for acute myocardial infarction: a national analysis over 11 months. Gastrointest Endosc. 2020 Jul;92(1):65-74.e2. doi: 10.1016/j.gie.2020.01.039. PMID: 32017916.

Singh S, Hourneaux de Moura DT, Khan A, Bilal M, Ryan MB, Thompson CC. Safety and efficacy of endoscopic sleeve gastroplasty worldwide for treatment of obesity: a systematic review and meta-analysis. Surg Obes Relat Dis. 2020 Feb;16(2):340-351. doi: 10.1016/j.soard.2019.11.012. Epub 2019 Dec 10. PMID: 31932205.

JAL Guacho, DTH de Moura, IB Ribeiro, AM da Ponte Neto, S Singh et al. Propofol versus midazolam sedation for elective endoscopy in patients with cirrhosis: A systematic review and meta-analysis of randomized controlled trials. World Journal of Gastrointestinal Endoscopy 2020; 12(8): 241-255. PMID: 32879659 doi: 10.4253/wjge.v12.i8.241

de Miranda Neto, A.A., de Moura, D.T.H., Ribeiro, I.B., Singh S, et al. Efficacy and Safety of Endoscopic Sleeve Gastroplasty at Mid Term in the Management of Overweight and Obese Patients: a Systematic Review and Meta-Analysis. OBESITY SURGERY 2020; 30, 1971–1987. PMID: 32107706. doi: 10.1007/s11695-020-04449-9.

Kotinda, A.P.S.T., de Moura, D.H., Ribeiro, I.B., Khan, A., Singh, S, et al. Efficacy of Intragastric Balloons for Weight Loss in Overweight and Obese Adults: a Systematic Review and Meta-analysis of Randomized Controlled Trials. OBESITY SURGERY 2020; 30, 2743–2753. PMID: 32300945. doi: 10.1007/s11695-020-04558-5.

Bilal M, Singh S, Le TT, Al-Saadi Y, Guturu P. Select group of patients might benefit from early colonoscopic screening for colorectal cancer. Surg Endosc. 2020 Oct;34(10):4463-4471. doi: 10.1007/s00464-019-07226-7. PMID: 31637604.

A Shah, M Al-Hanayneh, M Bilal, S Singh. Endoscopic Ultrasound Guided Liver Biopsy for Parenchymal Liver Disease. World Journal of Hepatology 2019; 11 (4), 335-343. PMID: 31114638 Doi: 10.4254/wjh.v11.i4.335

Syed A, Babich O, Rao B, Singh S et al. Endoscopic ultrasound guided fine‐needle aspiration vs core needle biopsy for solid pancreatic lesions: Comparison of diagnostic accuracy and procedural efficiency. Diagnostic Cytopathology. 2019 Nov;47(11):1138-1144. PMID: 31313531. doi: 10.1002/dc.24277.

Chowdhry M, Bilal M, Clanton J, Shah H, Singh S. Large Lymphoepithelial Cyst of Pancreas: A rare entity managed using Lumen-apposing Metal Stent. Case Report and review of the Literature. Clinical Journal of Gastroenterology 2019. 12(6):609-614. PMID: 30989626. doi: 10.1007/s12328-019-00982-y.

M Bilal, O Alhajjar, M Madisetty, V Kantamaneni, S Singh, M Babich, A Kapetanos. Adherence to Two Large-Bore Intravenous Lines in Acute Gastrointestinal Bleeding Is Low. Digestive Diseases and Sciences. 2019; 64 (3): 627-631. PMID: 30656564. doi: 10.1007/s10620-019-5455-7.

B Rao, A Syed, S Singh, et al. Performance of a Multidisciplinary Pancreas Cancer Conference in Predicting and Managing Resectable Pancreatic Cancer. Pancreas 2019; 48(1):80-84. PMID: 30451791. doi: 10.1097/MPA.0000000000001209.

A Syed, M Garg, P Patel, S Singh, et al. Fluoroscopy Dose and Time Characteristics During Endoscopic Retrograde Cholangiopancreatography (ERCP). Surgical Laparoscopy Endoscopy & Percutaneous Techniques 2019; 29 (1), 22-25. PMID: 30520816. doi: 10.1097/SLE.0000000000000603.

Mohy-ud-din N, Krill T, Shah A, Chatila A, Singh S, Bilal M, Parupudi S. Barrett's esophagus: What do we need to know?  Disease-a-Month, Dis Mon. 2020;66(1):100850. doi:10.1016/j.disamonth.2019.02.003. PMID: 30808502.

Sharma S, Singh S, et al. Carcinosarcoma of the pancreas: A rare type of pancreatic neoplasia. EC Gastroenterology and Digestive System 2019, 6(6): 439-444.

S Singh, M Chowdhry, M Bilal, K Clarke. Variations in medical treatment of Inflammatory Bowel Diseases among Gastroenterologists. Gastroenterology reports 2018; 6 (1), 61-64. PMID: 29479445. doi: 10.1093/gastro/gox005.

Rao, B; Garg, M; Singh, S et al. Successful use of radiofrequency ablation for the management of a recurrent ampullary adenoma with intraductal extension. VideoGIE 2018; 3 (3), 94-96. PMID: 29916472. doi: 10.1016/j.vgie.2017.12.002.

Saraireh, H. A., Bilal, M., & Singh, S. Role of endoscopic ultrasound in liver disease: Where do we stand in 2017? World Journal of Hepatology 2017, 9(24), 1013–1021. PMID: 28932347. doi: 10.4254/wjh.v9.i24.1013.

Umar, S., Clarke, K., Bilimoria, F., Bilal, M., Singh, S., & Silverman, J. Diagnostic yield from colon biopsies in patients with inflammatory bowel disease and suspected cytomegalovirus infection: is it worth it? Annals of Gastroenterology 2017, 30(4), 429–432. PMID: 28655979. doi: 10.20524/aog.2017.0153.

Bilal M, Singh S, Lee H, Khosa K, Khehra R, Clarke K. Bridges to excellence quality indicators in inflammatory bowel disease (IBD): differences between IBD and non-IBD gastroenterologists. Annals of Gastroenterology 2017; 30(2), 192–196. PMID: 28243040. doi: 10.20524/aog.2016.0114.

Singh S, Dhawan M, Chowdhry M, Babich M, Aoun E. Differences between morning and afternoon colonoscopies for adenoma detection in female and male patients. Annals of Gastroenterology 2016, 29(4), 497–501. doi: 10.20524/aog.2016.0079. PMID: 27708517.

Gomez G, Singh S, Kentamaneni V, Indramohan P, Bilal M, Morrissey S, Thakkar S, Abdul-Baki H, Dhawan M. Effect of Morning vs Afternoon Scheduling of Endoscopic Ultrasound-Guided Fine Needle Aspiration on Outcomes of Solid Pancreatic Lesions. Minerva Gastroenterol Dietol 2017; 63 (2), 163-165. doi: 10.23736/S1121-421X.17.02358-3. PMID: 28391675.

Singh, S, Purohit T, Aoun E, Patel Y, Carleton N, Mitre M, Morrissey S, Dhawan M, Thakkar S. Comparison of the Outcomes of Endoscopic Ultrasound Based on Community Hospital Versus Tertiary Academic Center Settings. Dig Dis Sci. 2014 Aug; 59(8): 1925-30. PMID: 24573718. doi: 10.1007/s10620-014-3075-9.

Singh, S. Colonoscopy withdrawal time and adenoma detection rates for trainees. Surg Endosc. 2013 Jun;27(6):2243-4. PMID: 23292564. doi: 10.1007/s00464-012-2723-4.

Singh, S, Goyal V, Padhi P, Aoun E. Bacteroides fragilis endocarditis in a patient with Crohn's disease. BMJ Case Rep. 2013 Apr 18;2013. PMID: 23605837. doi: 10.1136/bcr-2013-009248.

Singh, S, Aoun E, Thakkar S. Endoscopic management of a major bile duct stricture from surgical clips following laparoscopic hemicolectomy. BMJ Case Rep. 2013 Feb 27;2013. PMID: 23446047. doi: 10.1136/bcr-2012-007982.

Singh, S, Parihar G, Rao R, Goyal V. Focal left atrial tachycardia in a patient with left ventricular noncompaction. Case Rep Med. 2013;2013:430862. PubMed PMID: 23762071. doi: 10.1155/2013/430862.

Singh, S. Polyp detection rates: a possible surrogate for colonoscopy competency in addition to cecal intubation. Am J Gastroenterol. 2012 Dec; 107(12) 1925-6. PMID: 23211860. doi: 10.1038/ajg.2012.349.

Padhi P, Singh, S. Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Small Cell Carcinoma of the Lung. Journal of Cancer Science and Therapy. 2012 Jun; 4(6): 164-166. doi:10.4172/1948-5956.1000133.

S Talal,  S Aslam, S Singh et al.  Lung Metastasis in Pancreatic Cancer: Should Staging Chest CT be Routinely Performed? Submitted for publication.

M Baliss, M Bilal, T S. Krill, S Umar, MS Abougergi, AR Shah, S Chandan, S Singh et al. One Year Risk of Opioid Addiction After an Episode of Acute Pancreatitis and its Impact on Mortality and Healthcare Resource Utilization. Submitted for publication.

Bilal M, Singh S et al. Use of Fully Covered Self-Expanding Metal Biliary Stents for Managing Endoscopic Biliary Sphincterotomy Related Bleeding. Accepted Endoscopy International Open.

L Maciolek, K Kline, M Bilal, S Singh, et al. Adherence to Preventative Health Care in Inflammatory Bowel Disease is Low. Submitted for publication.

C Patel, A Khan, S Singh. Fecal Belching: A Case of Malignant Gastrocolic Fistula. Submitted for publication.

C Patel, S Singh. Endoscopic Treatment of a Bronchoesophageal Fistula After Radiation Therapy. Submitted for publication.

E.S do Monte Junior, I.B Ribeiro, D.T.H  de Moura, S Singh, et al. Esophageal rendezvous technique and self-expanding metal stent in a patient with complete obstruction due to bullous pemphigoid: A Case Report and An Evidence-Based Review. Submitted for publication.

S Singh et al. Impact of COVID-19 pandemic on New Diagnosis of Gastrointestinal Cancers and Outcomes of COVID-19 among patients with Pre-existing Gastrointestinal Cancers in United States. Submitted for publication Gastroenterology.

 

Membership and Honorary/Professional Societies

Moderator Digestive Disease Week 2020, Chicago

Member American Society of Gastrointestinal Endoscopy (ASGE) DDW International Clinical Symposia Committee

International Committee Member American College of Gastroenterology (ACG)

Member American Association of Bariatric Endoscopy (ABE) 

Member American Gastroenterological Association (AGA)

Member American Society for Gastroenterological Endoscopy (ASGE)

Dr. Shailendra Singh is Professor of Medicine and Director of Advanced Therapeutic Endoscopy at West Virginia University (WVU) in Morgantown, West Virginia. He earned his medical degree from Maulana Azad Medical College, Delhi University, India, and completed his residency and fellowship training in Pittsburgh at Allegheny Health Network and the University of Pittsburgh. Dr. Singh specializes in minimally invasive endoscopic procedures, with particular focus on bariatric and surgical endoscopy and advanced endoscopy procedures like Endoscopic Ultrasound (EUS) and ERCP.

Internationally recognized for his expertise, he has authored more than 150 peer-reviewed publications in leading journals and holds multiple patents. He is regarded as a national leader in the performance and teaching of Endoscopic Sleeve Gastroplasty (ESG), EUS-guided ablations, and other interventional endoscopic procedures, and currently leads pivotal U.S. clinical trials in endoscopic weight loss (ESG), metabolic intervention (duodenal mucosal resurfacing), and interventional EUS.

At WVU, Dr. Singh helped establish a state-of-the-art multidisciplinary Advanced Endoscopy Center dedicated to innovation, clinical excellence, and patient-centered care. He was recently honored with the Rising Star Award from the National Pancreas Foundation in recognition of his contributions to pancreatic disease research and the advancement of therapeutic endoscopy.

Dr. Singh frequently serves as course director and faculty at national and international endoscopy courses and workshops, delivering lectures and live case demonstrations both in the United States and abroad. He co-founded the West Virginia Interventional and Surgical Endoscopy (WISE) course. He actively mentors medical students, residents, gastroenterology fellows, and advanced endoscopy trainees while providing guidance to colleagues across the country. He also serves as doctoral dissertation advisor and supervisor for PhD candidate in WVU's Clinical and Translational Science program.

Dr. Singh holds leadership roles on several national committees, including the American Gastroenterological Association (AGA) Clinical Guidelines Committee—through which he co-authored AGA Clinical Practice Guidelines—the Bariatric Advisory Board of the American Society for Gastrointestinal Endoscopy (ASGE), and the Digestive Disease Week (DDW) Planning Committee. He also serves on the editorial board and as a reviewer for numerous gastroenterology journals, contributing to clinical practice, guidelines, and innovation in gastroenterology and advanced endoscopy.

Expertise in advanced endoscopic procedures include:

• EUS-FNA
• EUS-guided biliary drainage; pancreatic fluid collection drainage; gallbladder drainage
• ERCP
• Cholangioscopy
• Transoral Incisionless Fundoplication (TIF)
• EGD/Colonoscopy with resection of Large polyp/EMR
• Barrett's ablation, Barrett's EMR
• EGD/Colonoscopy with dilation and luminal stenting

Expertise in bariatric endoscopy procedures include:

• Minimally invasive, incision-less weight loss therapies, including the intra gastric balloon and endoscopic sleeve gastroplasty (ESG)
• Endoscopic suturing to reduce the size of the gastric pouch and outlet for patients who have regained weight after gastric bypass
• Management of postsurgical complications including post-surgery leak, stricture and fistula 

Research & Publications

https://www.researchgate.net/profile/Shailendra_Singh61

https://orcid.org/0000-0001-9505-4842

Google Scholar: https://scholar.google.com/citations?hl=en&user=w6opyYoAAAAJ&view_op=list_works&sortby=pubdate

CLINICAL TRIALS & GRANTS

1. PI: Migration rates of sutured vs non-sutured esophageal stent placement. Randomized control Trial. Protocol Number: 2101223876. Investigator-initiated study at West Virginia University

2. PI: Microbial isolation from duodenoscopes. Protocol Number: 2101209088. Investigator-initiated study at West Virginia University. Received funding from WVU Medicine Innovation Funds.

3. Co-PI: Endoscopic Ultrasound-guided Chemoablation of Pancreatic Cystic Tumors. Protocol Number 2202531612 Investigator-initiated study at West Virginia University

4. PI: NCT05507151 Effectiveness of endoscopic sleeve gastroplasty in nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Protocol Number: 2202523300

5. PI: Endoscopic Ultrasound-guided Radiofrequency Ablation of Celiac Ganglion for pain management and improvement of quality of life in patients with unresectable pancreatic cancer. Protocol Number: 2202520088. Received funding from GI 21ᵀᴹ Foundation and National Pancreas Foundation

6. PI: A Prospective, Randomized, Double-Blind, Sham Controlled, Multi-Center Pivotal Study to Evaluate the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita® System in Subjects with Type 2 Diabetes on Insulin therapy RevitaT2Di Pivotal Study Protocol Number: C-00044

7. PI: Fractyl Hub: A Prospective, Randomized, Double-Blind, Sham- Controlled, Multi-Center Pivotal Study to Evaluate the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita System in Subjects with Type 2 Diabetes on Insulin Therapy

8. PI: Sampling and Culturing Study of the Olympus TJF-Q190V Duodenoscope to Assess Contamination Risk Following Reprocessing. Post market Surveillance (PS) Study Plan PS200003

9. Co-PI (Advarra) A Phase 4 Study to Assess Symptoms of Exocrine Pancreatic Insufficiency in Subjects with Cystic Fibrosis or Chronic Pancreatitis Treated with Creon(R) (Pancrelipase) with an Alternate Source of Active Pharmaceutical Ingredient

10. Co-PI DESTIN: RANDOMIZED TRIAL COMPARING IMMEDIATE ENDOSCOPIC NECROSECTOMY VS. STEP-UP ENDOSCOPIC INTERVENTIONS IN NECROTIZING PANCREATITIS

11. PI: Endoscopic Sleeve Gastroplasty plus Semaglutide Versus Endoscopic Sleeve Gastroplasty plus Lifestyle Interventions for weight loss: A Ballam’s design RCT

12. Co-PI: RANDOMIZED TRIAL COMPARING ENDOSCOPIC ULTRASOUND-GUIDED GASTROJEJUNOSTOMY AND SURGICAL GASTROJEJUNOSTOMY IN GASTRIC OUTLET OBSTRUCTION

13. Co-Investigator: PEG-J vs PEJ for post-pyloric feeding: Pennsylvania Society of Gastroenterology Research grant

14. RANDOMIZED TRIAL OF EUS-GUIDED CELIAC PLEXUS BLOCK VS. SHAM FOR PALLIATION OF PAIN IN CHRONIC PANCREATITIS (EPOCH TRIAL)

15. PI: A Prospective, Randomized, Double-Blind, Sham-Controlled, Multicenter, Pivotal Study to Assess the Efficac Maintenance in Participants with Obesity and Who Have Achieved at Least 15% Weight Loss on Tirzepatide Obesity Pharmacotherapy (REMAIN-1)

16. PI: REMAIN-1-FRACTYL-HUB: A Prospective, Randomized, Double-Blind, Sham-Controlled, Multicenter, Pivotal Study to Assess the Efficacy of Revita® Duodenal Mucosal Resurfacing (DMR) on Body Weight Maintenance in Participants with Obesity and Who Have Achieved at Least 15% Weight Loss on Tirzepatide Obesity Pharmacotherapy (REMAIN-1)

17. PI: Paclitaxel Coated balloon for the Treatment of chronic bEnigN sTricture-Esophagus (PATENT-E)

18. PI: Paclitaxel Coated balloon for the Treatment of chronic bEnigN sTricture-Bowel (PATENT-B)

19. PI: Effect of Endoscopic Sleeve Gastroplasty (ESG) on Patients with Obesity and Concomitant Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Multicenter, Open-label, Randomized Controlled Trial

20. PI: ENLIGHT Trial: Effect of Endoscopic Sleeve Gastroplasty (ESG) with Fundal Mucosal Ablation (FMA) on Weight Loss, Obesity-Related Comorbidities, and Metabolic Outcomes: A Randomized Controlled Trial. Received Department of Medicine Innovation Grant

21. PI: EUS guided Tumor Ablation Prospective Registry (Radio Frequency Ablation /Microwave Ablation)

22. Co-PI: Microwave ablation for treatment of Pancreatic Ductal Adenocarcinoma. Received grant for Creo Medical

Medical Specialties

• Gastroenterology

Board Certifications

• Gastroenterology, American Board of Internal Medicine
• Internal Medicine, American Board of Internal Medicine

Special Training

• Fellowship, Gastroenterology & Hepatology
  Allegheny Health Network, Pittsburgh, PA, 2017
• Fellowship, EUS, ERCP Advanced Endoscopy
  Allegheny Health Network, Pittsburgh, PA, 2017
• Fellowship, Geriatric Medicine
  University of Pittsburgh, Pittsburgh, PA, 2014
• Residency, Internal Medicine
  Allegheny Health Network, Pittsburgh, PA, 2013