Jonathan Boyd, PhD

Associate Professor

Organization:

West Virginia University School of Medicine

Department:

Physiology, Pharmacology & Toxicology

Classification:

Faculty

1. Prince N, Penatzer JA, Shackleford TL, Dietz MJ, Boyd JW. Tissue-level cytokines in a rodent model of periprosthetic joint infection. Journal of Orthopaedic Research. Accepted 2020.
2. Sangani R, Rojas E, Forte M, Zulfikar R, Prince N, Tasoglou A, Goldsmith T, Casuccio G, Olfert M, Boyd, JW, Flanagan M, Sharma S. Electronic cigarettes and Vaping Associated Lung Injury (EVALI): Rural Appalachian Experience. Hospital Practice. Accepted 2020
3. Prince N, Penatzer J, Dietz M, Boyd J. Localized cytokine responses to total knee arthroplasty and total knee revision complications. Journal of Translational Medicine 18, 330. 2020. 
3. Prince N, Penatzer JA, Dietz MJ, Boyd JW. Impact of cytokines and phosphoproteins in response to chronic joint infection. Biology 9(7), 167. 2020.  
4. Penatzer JA, Miller JV, Han AA, Prince N, Boyd JW. Salivary cytokines as a biomarker of social stress in a mock hostage rescue mission. Brain, Behavior, & Immunity – Health 4, 1-6. 2020. 
5. Boyd J, Penatzer J, Prince N, Miller J, Han A, Currie H. Chapter 1: Bioenergetic Analyses of In Vitro and In Vivo Samples to Guide Toxicological Endpoints. In Molecular Toxicology Protocols. Eds. P. Keohavong, K. Singh, and W. Gao. Springer International Publishing Switzerland. ISBN: 978-1-0716-0222-5. 2020. 
6. Cellular Signal Transduction In Toxicology and Pharmacology. Eds. J. Boyd and R. Neubig. John Wiley & Sons Limited, Hoboken, NJ.  ISBN: 978-1-119-06026-0. 2019. 
7. Boyd J, Neubig R, Han A, Prediger M. Chapter 1: Introduction to Cellular Signal Transduction: The connection between a biological system and its surroundings. In Cellular Signal Transduction In Toxicology and Pharmacology. Eds. J. Boyd and R. Neubig. John Wiley & Sons Limited, Hoboken, NJ. ISBN: 978-1-119-06026-0. 2019. 
8. Neubig R, Boyd J, Penatzer J. Chapter 2: Mechanisms of Cellular Signal Transduction. In Cellular Signal Transduction In Toxicology and Pharmacology. Eds. J. Boyd and R. Neubig. John Wiley & Sons Limited, Hoboken, NJ. ISBN: 978-1-119-06026-0. 2019. 
9. Miller JV, Prince AN, Penatzer JA, Boyd JW. Chapter 8: A Toxicological Application of Signal Transduction: Early Cellular Changes Can Be Indicative of Toxicity. In Cellular Signal Transduction In Toxicology and Pharmacology. Eds. J. Boyd and R. Neubig. John Wiley & Sons Limited, Hoboken, NJ. ISBN: 978-1-119-06026-0. 2019. 
10. Boyd J, Prince N, Birringer M. Chapter 9: Future Research in Signaling. In Cellular Signal Transduction In Toxicology and Pharmacology. Eds. J. Boyd and R. Neubig. John Wiley & Sons Limited, Hoboken, NJ. ISBN: 978-1-119-06026-0. 2019.
11. Dietz MJ, Hare JT, Ueno C, Prudhomme BJ, Boyd JW. Laser Assisted Fluorescence Angiography to Assess Tissue Perfusion in the Setting of Traumatic Elbow Dislocation. Wounds. 30(10) E93-E97. 2018.
12. Han AA, Currie HN, Loos MS, Scardoni G, Miller JV, Boyd JW. The impact of cytokine responses in the intra- and      extracellular signaling network of a traumatic injury. Cytokine 106, 136-147. 2018. 

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel (SAP) Nominee, 2018 

Innovation, Design and Entrepreneurship Faculty Fellowship, West Virginia University, 2016-2018

Invited Keynote Speaker for C. Eugene Bennett Foundation Careers for Chemists Program, West Virginia University, 2015

Global Medical Discovery names “Forecasting cell death dose-response from early signal transduction responses in vitro” (Toxicological Sciences 140, 338-51. 2014) a Key Scientific Article contributing to biomedical research excellence, 2014

Early Career Innovator of the Year Award, West Virginia University, 2013

West Virginia State American College of Surgeons, Best Paper for "Spatial cytokine distribution following traumatic injury ", 2012

Linking Innovation, Industry and Commercialization (LIINC), Best Intellectual Property Idea of the Evening for "Diagnostic Drugs", 2011

Society of Toxicology, Mixtures Specialty Section Best Abstract Award for "Cell Signal Transduction to Predict Mixture Interactions", 2011

Defense Advanced Research Projects Agency Young Faculty Award, 2009

Hart Prize for Excellence in Independent Research for “Detection of Low Vapor Pressure Materials”, 2008

Keynote speaker, Spring Banquet Awards Ceremony of The Institute of Environmental and Human Health, Lubbock, TX. 2008

Original vapor generation technique (Boyd, et al. 2006) was used as the basis for the DARPA Emissions Program testbed, and was successfully transitioned to three large defense conglomerates and one U.S. national laboratory

Chemical Warfare Expert for the Homeland Security Institute Amber Mist: Chemical Countermeasures Tabletop Exercise, 2005

Annual ANSER Board of Trustees Award, 2005

The Institute of Environmental and Human Health, Texas Tech University, Doctoral Fellowship, 2000-2004

Jonathan Boyd, Ph.D. is a Professor (with tenure) at West Virginia University (WVU) in the Department of Orthopaedics within the School of Medicine (SOM).  Additionally, he holds appointments in the Department of Physiology and Pharmacology in the SOM, the Department of Occupational and Environmental Health Sciences in the School of Public Health, the Intercollegiate Undergraduate Program in Biochemistry at WVU, the Department of Oecotrophologie at Fulda University of Applied Sciences, and is a Guest Researcher for the National Institute of Occupational Safety and Health (NIOSH) at the Centers for Disease Control and Prevention.  He earned the rank of Associate Professor (with tenure) in 2015 in the C. Eugene Bennett Department of Chemistry at West Virginia University, prior to beginning his current faculty appointment in the SOM in 2018.  He obtained his B.S. in Biochemistry from the University of Texas at Austin and his Ph.D. in Environmental Toxicology from Texas Tech University. 

In his research, Dr. Boyd uses fundamental signaling principles to investigate the responses of living systems to changes in their local environment, which often simplifies to following the energy within an organism in response to stimulae.  Rather than regarding insults (e.g., traumatic injury, prosthetic joint infection, etc.) as uncharacterized supervillains wreaking havoc on unprotected and defenseless tissues, his aim is to understand systemic robustness and the molecular impacts of these assaults on functional mechanisms.  His goal is to go beyond identifying adverse effects through trial and error, but rather forecast cellular bifurcations associated with signaling at concentrations above background noise, which requires an understanding of the localized complex environment and direct linkage to clinical observations.  This unique research focus has enabled Dr. Boyd to work translationally across multiple hierarchal levels of biological samples that include mammalian cell culture, animal models (rodents) and human subjects, coupled with a multitude of analytical techniques that range from single point detectors to state-of-the-art imaging.  As a basic scientist, the application of his research is broad and spans toxicity screening to medical diagnostics and inflammation-related disease etiology. 

At WVU, Dr. Boyd’s teaching responsibilities include both formal courses and student training.  His courses have been in the areas of Orthopaedics, Biochemistry, and Toxicology at both the undergraduate and graduate levels.  Dr. Boyd has directed 10 undergraduate research projects and served on 34 graduate student committees (primary advisor for 8) with his students receiving numerous awards and fellowships. His placement record for students includes: University of Cambridge, Harvard University, Ohio State University, University of Pennsylvania, Leibniz University, California University, Pacific Northwest National Laboratory, and Centers for Disease Control and Prevention.

In addition to his research and teaching at WVU, Dr. Boyd serves as the Associate Director of the Musculoskeletal Laboratory, which includes 4000+ square feet of laboratory space and multiple faculty and staff.  He is also the Director of Graduate Studies for the Department of Orthopaedics, which involves the management of graduate curriculum for Ph.D. and MD/Ph.D. students.  His global outreach includes roles as the WVU Program Director of the International Science Student Exchange and U.S. Organizer of the International Spring School at Fulda University of Applied Sciences.  Further, Dr. Boyd has been instrumental in the design and development of a new Center for Inhalational Toxicology at West Virginia University, initially serving as the Basic Science lead (pre-Center status) and now serving on the Advisory Board. 

Surgical Science, Cellular and Integrative Physiology, Center for Inhalational Toxicology, Occupational and Environmental Health Sciences

Dr. Boyd’s research uses fundamental thermodynamic principles to investigate inflammation in living systems. In general, he is interested in understanding the mammalian response to stressors, and specifically, he is working toward an understanding of how humans integrate (from cellular mechanisms to physiological function) chemical and biochemical signals in response to stimulae.  Research in our group involves multiple hierarchal levels of biological samples that include cell culture, animal models and human subjects coupled with analytical techniques that range from single point detectors to state-of-the-art multidimensional MS and imaging.  

The Boyd Research Group immersive scientific team that is at the leading edge of clinical science.  We work with surgeons and scientists toward unraveling the robustness of human responses.  While our research problems come directly from the clinic, we are a basic science research group that is aimed at discovery.  We do work with closely with many academic, government and industry partners to develop scientific solutions that are able to be translated directly back into the field or operating room. 

• Comparative inflammation associated with chemical and pharmacological exposures.
• Neurological inflammation caused by stress and chemical exposures.
• Wound healing on the International Space Station caused by trauma resulting from a femur fracture.
• Cerebral vascular dysfunction and stroke caused by inhalational hazards.