person

James J. Mahoney, PhD

Associate Professor/Clinical Neuropsychologist

Contact

Address
930 Chestnut Ridge Road
Morgantown, WV 26505
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Education

  • PhD, University of Houston, 2014
  • MA, Pepperdine University (Los Angeles, California), 2007

Publications

2025

Rezai A, Thompson-Lake DGY, D'Haese PF, Meyer N, Ranjan M, Farmer D, Finomore V, Marton JL, Hodder S, Carpenter J, Bhagwat A, Berry J, Tirumalai P, Adams G, Arsiwala TA, Blanke O, Mahoney JJ 3rd. Focused Ultrasound Neuromodulation: Exploring a Novel Treatment for Severe Opioid Use Disorder. Biol Psychiatry 2025;9:S0006-3223(25)00023-X. Epub ahead of print. PMID: 39798597. DOI: 10.1016/j.biopsych.2025.01.001

2024

Gotra M, Lindberg K, Jasinski N, Scarisbrick D, Reilly S, Perle J, Miller L, Mahoney III J. Changes in the Clinical Practice of Mental Health Service Providers Throughout the COVID-19 Pandemic: Longitudinal Questionnaire Study. JMIR Form Res 2024;8:e50303. PMID: 38683653. PMCID: PMC11060325. DOI: 10.2196/50303

Mahoney JJ, Miller LE, Haut MW. Chapter 38: Substance abuse, prescribed medications, and toxin exposure. In: Boyle GJ, Stern Y, Stein DJ, Sahakian BJ, Golden CJ, Lee TMC, Chen SHA (eds), The SAGE Handbook of Clinical Neuropsychology: Clinical Neuropsychological Disorder 2024. SAGE Publications Ltd. ISBN: 9781529717754 [E-book ISBN: 9781529766707]

Mahoney JJ, Thurn R, Patel V. Non-invasive and Invasive Forms of Neuromodulation for the Treatment of Psychiatric Disorders. Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier 2024. DOI: 10.1016/B978-0-323-95702-1.00159-7

Petersen J, McGough J, Gopinath G, Scantlebury N, Tripathi R, Brandmeir C, Boshmaf SZ, Brandmeir NJ, Sewell IJ, Konrad PE, Abrahao A, Murray A, Lam B, Ranjan M, Hamani C, Frey J, Rohringer C, McSweeney M, Mahoney JJ 3rd, Schwartz ML, Rezai A, Lipsman N, Scarisbrick DM, Rabin JS. Cognitive outcomes following unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: findings from two cohorts. Brain Commun 2024;6(5):fcae293. PMID: 39291168. PMCID: PMC11406546. DOI: 10.1093/braincomms/fcae293

Ranjan M, Mahoney JJ 3rd, Rezai AR. Neurosurgical neuromodulation therapy for psychiatric disorders. Neurotherapeutics 2024;21(3):e00366. PMID: 38688105. PMCID: PMC11070709. DOI: 10.1016/j.neurot.2024.e00366

Thompson-Lake D, Mahoney J, Haut M, Carpenter J, Marton J, Zheng W, Berry J, Ranjan M, Tirumalai P, Mears A, D'Haese P, Finomore V, Rezai A. First in the World Trial of low Intensity Focused Ultrasound for Substance Use Disorder. Drug and Alcohol Dependence 2024;260(Supplement):109956. DOI: 10.1016/j.drugalcdep.2023.109956

2023

Mahoney JJ 3rd, Finomore VS, Marton JL, Ramadan J, Hodder SL, Thompson-Lake DGY, Marsh CB, Koch-Gallup N, Ranjan M, Rezai AR. Identifying biomarkers of drug use recurrence using wearable device technologies and phone applications. Drug Alcohol Depend 2023;249:110817. PMID: 37331302. PMCID: PMC10416187. DOI: 10.1016/j.drugalcdep.2023.110817

Mahoney JJ, Haut MW, Carpenter J, Ranjan M, Thompson-Lake DGY, Marton JL, Zheng W, Berry JH, Tirumalai P, Mears A, D’Haese P, Finomore VS, Hodder SL, Rezai AR. Low-intensity focused ultrasound targeting the nucleus accumbens as a potential treatment for substance use disorder: safety and feasibility clinical trial. Frontiers in Psychiatry 2023;14. DOI: 10.3389/fpsyt.2023.1211566

Mahoney JJ 3rd, Thompson-Lake DGY, Ranjan M, Marton JL, Carpenter JS, Zheng W, Berry JH, Farmer DL, D'Haese P, Finomore VS, Tirumalai P, Mears AS, Suffridge J, Ames A, Hodder SL, Rezai AR. Low-Intensity Focused Ultrasound Targeting the Bilateral Nucleus Accumbens as a Potential Treatment for Substance Use Disorder: A First-in-Human Report. Biol Psychiatry 2023. Epub ahead of print. PMID: 37610405. DOI: 10.1016/j.biopsych.2023.06.031

Mahoney JJ 3rd, Winstanley EL, Castillo F, Luba r, Marton J, Alschuler DM, Liu Y, Comer SD. A pilot study investigating cognitive impairment associated with opioid overdose. Drug and Alcohol Dependence 2023;247:109865. PMID: 37094488. PMCID: PMC10230403. DOI: 10.1016/j.drugalcdep.2023.109865

Muksuris K, Scarisbrick DM, Mahoney JJ 3rd, Cherkasova MV. Noninvasive Neuromodulation in Parkinson's Disease: Insights from Animal Models. J Clin Med 2023;12(17):5448. PMID: 37685514. PMCID: PMC10487610. DOI: 10.3390/jcm12175448

Perle JG, Perle AR, Scarisbrick DM, Mahoney JJ 3rd. A Preliminary Investigation of Telehealth-Focused Supervision in Clinical Psychology Pre-doctoral Internships and Post-doctoral Fellowships Before and After the Onset of COVID-19. Journal of Technology in Behavioral Science 2023. DOI: 10.1007/s41347-023-00353-y

Rezai AR, Mahoney JJ, Ranjan M, Haut MW, Zheng W, Lander LR, Berry JH, Farmer DL, Marton JL, Tirumalai P, Mears A, Thompson-Lake DGY, Finomore VS, D'Haese PF, Aklin WM, George DT, Corrigan JD, Hodder SL. Safety and feasibility clinical trial of nucleus accumbens deep brain stimulation for treatment-refractory opioid use disorder. Journal of Neurosurgery 2023:1-9. Epub ahead of print. PMID: 37329519. DOI: 10.3171/2023.4.JNS23114

2022

Mahoney JJ 3rd, Koch-Gallup N, Scarisbrick DM, Berry JH, Rezai AR. Deep brain stimulation for psychiatric disorders and behavioral/cognitive-related indications: Review of the literature and implications for treatment. J Neurol Sci 2022;437:120253. PMID: 35460949. DOI: 10.1016/j.jns.2022.120253

Perle JG, Perle AR, Scarisbrick DM, Mahoney JJ 3rd. Educating for the Future: a Preliminary Investigation of Doctoral-Level Clinical Psychology Training Program's Implementation of Telehealth Education. J Technol Behav Sci 2022;7(3):351-357. PMID: 35382354. PMCID: PMC8972773. DOI: 10.1007/s41347-022-00255-5

Perle JG, Perle AR, Scarisbrick DM, Mahoney JJ 3rd. Fostering telecompetence: A descriptive evaluation of clinical psychology predoctoral internship and postdoctoral fellowship implementation of telehealth education. J Rural Health 2022. PMID: 36042001. DOI: 10.1111/jrh.12709

2021

Mahoney JJ, Haut MW, Hodder SL, Zheng W, Lander LR, Berry JH, Farmer DL, Marton JL, Ranjan M, Brandmeir NJ, Finomore VS, Hensley JL, Aklin WM, Wang GJ, Tomasi D, Shokri-Kojori E, Rezai AR. Deep brain stimulation of the nucleus accumbens/ventral capsule for severe and intractable opioid and benzodiazepine use disorder. Experimental and Clinical Psychopharmacology 2021;29(2):210-5. PMID: 34043402. DOI: 10.1037/pha0000453

Mahoney JJ, Winstanley EL, Lander LR, Berry JH, Marshalek PJ, Haut MW, Marton JL, Kimble WD, Armistead, Wen S, Cai Y, Hodder SL. High prevalence of co-occurring substance use in individuals with opioid use disorder. Addictive Behaviors 2021;114:106752. PMID: 33348147. DOI: 10.1016/j.addbeh.2020.106752

Reilly SE, Soulliard ZA, McCuddy WT, Mahoney JJ. Frequency and perceived effectiveness of mental health providers’ coping strategies during COVID-19. Current Psychology 2021;1-10. PMID: 33867779. PMCID: PMC8041948. DOI: 10.1007/s12144-021-01683-x

Winstanley EL, Mahoney JJ 3rd, Castillo F, Comer SD. Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A systematic review. Drug and Alcohol Dependence 2021;226:108838. PMID: 34271512. DOI: 10.1016/j.drugalcdep.2021.108838

Zane KL, McCuddy WT, Mahoney III JJ, Kelty MK, Scarisbrick DM. Assessing Psychometrists' Practices to Inform Neuropsychological Services. Arch Clin Neuropsychol 2021;36(5):693-701. PMID: 33316054. PMCID: PMC8292924. DOI: 10.1093/arclin/acaa122

Zane KL, Thaler NS, Reilly SE, Mahoney JJ 3rd, Scarisbrick DM. Neuropsychologists' practice adjustments: The impact of COVID-19. Clin Neuropsychol 2021;35(3):490-517. PMID: 33371799. PMCID: PMC8381282. DOI: 10.1080/13854046.2020.1863473

 

Research Manuscripts (Peer-Reviewed)

*Abbreviated list from 68 total peer-reviewed published manuscripts

Complete List of Published Works: https://www.ncbi.nlm.nih.gov/myncbi/189OsqqAyVeQS/bibliography/public/

 

  1. Mahoney, III, J.J., Kalechstein, A.D., De Marco, A.P., Newton, T.F. & De La Garza, II, R. (2017). The relationship between premorbid IQ and neurocognitive functioning in individuals with cocaine use disorders. Neuropsychology, 31, 311-318.

  2. Mahoney, III, J.J., Bajo, S.D., De Marco, A.P., Arredondo, B.C. & Broshek, D. K. (2017). Referring providers’ preferences and satisfaction with neuropsychological services. Archives of Clinical Neuropsychology, 32, 427-436.

  3. Mahoney, III, J.J., Haile, C.N., De La Garza, II, R., Thakkar, H., & Newton, T.F. (2017). Electrocardiographic characteristics in individuals with cocaine use disorder. American Journal on Addictions, 26, 221-227.

  4. Mahoney, III, J.J., Kalechstein, A.D., Newton, T.F. & De La Garza, II, R. (2017). The limited impact that cocaine use patterns have on neurocognitive functioning in individuals with cocaine use disorder. Journal of Psychopharmacology, 31, 989-995.

  5. Mahoney, III, J.J. (2019). Cognitive Dysfunction in Individuals with Cocaine Use Disorder: Potential Moderating Factors and Pharmacological Treatments. Experimental and Clinical Psychopharmacology, 27, 203-214.

  6. Mahoney, III, J.J., Marshalek, P.J., Rezai, A., Lander, L.R., Berry, J.H., & Haut, M.W. (2020). A Case Report Illustrating the Effects of Repetitive Transcranial Magnetic Stimulation on Cue-Induced Craving in an Individual with Opioid and Cocaine Use Disorder. Experimental and Clin. Psychopharmacology, 28, 1-5.

  7. Mahoney, III, J.J., Hanlon, C.A., Marshalek, P.J., Rezai, A., & Krinke, L. (2020). Transcranial Magnetic Stimulation, Deep Brain Stimulation, and Other Forms of Neuromodulation for Substance Use Disorders: Review of Modalities and Implications for Treatment. Journal of Neurological Sciences, 418, 117149.

  8. Mahoney, III, J.J., Winstanley, E., Lander, L.R., Berry, J.H., Marshalek, P.J., Haut, M.W., Marton, J., Kimble, W., Armistead, M., Wen, S., Cai, Y., & Hodder, S. (2020). High Prevalence of Co-Occurring Substance Use in Opioid Use Disorder.  Addictive Behaviors. 114, 106752.

  9. Mahoney, III, J.J., Haut, M., Hodder, S., Zheng, W., Lander, L., Berry, J., Farmer, D.L., Marton, J.L., Brandmeir, N., Ranjan, M., Finomore, V., Hensley, J.L., Aklin, W.M., Wang, G., Tomasi, D., Shokri-Kojori, E., & Rezai, A. (2021). Deep Brain Stimulation of the Nucleus Accumbens/Ventral Capsule for Co-occurring Opioid and Benzodiazepine Use Disorder. Experimental and Clinical Psychopharmacology, 29, 210-215.

  10. Mahoney, III, J.J., Koch-Gallup, N., Scarisbrick, D.M., & Rezai, A.R. (2022). Deep Brain Stimulation for Psychiatric Disorders and Behavioral/Cognitive-Related Indications: Review of the Literature and Implications for Treatment. Journal of Neurological Sciences, 437, 120253.

Additional Info

Additional Information

 

Academic Honors

 

2016     University of Virginia – Scientist-Practitioner Scholar Fellowship Award

2017    American Psychological Association, Division 28 – Young Psychopharmacologist Award

2017    West Virginia University School of Medicine – Chairman’s Research Award

2018    Bridgewater College – Young Alumnus Award

2019    Journal of Experimental and Clinical Psychopharmacology – Editorial Fellowship

2020    West Virginia University School of Medicine – Chairman’s Research Award

2022    WVU School of Medicine – Chancellor’s Outstanding Achievement in Research Award

 

 

Professional Abstracts

 

*Abbreviated list from 95 total professional abstracts

 

  1. Keith, C., McCuddy, W., Nose, K., Lander, L., Haut, M., Berry, J., Harvey, D., Mahoney, III, J.J., (2019, February). The Relationship between Cognition and Potential Moderating Factors in Individuals with Opioid Use Disorder. International Neuropsychological Society, New York, NY.
  2. Mahoney, III, J.J., Berry, J.H., Lander, L.R., Winstanley, E., Marshalek, P.J., Haut, M.W., Marton, J., Hodder, S., Kimble, W., Armistead, M. (2019, April).  The Prevalence of Poly-Substance Use among Psychiatric and Emergency Department Patients in West Virginia. Annual Meeting of the West Virginia Clinical and Translational Science Institute, White Sulphur Springs, WV.
  3. Mahoney, III, J.J., Berry, J., Lander, L., Winstanley, E., Marshalek, P., Haut, M., Marton, J., Hodder, S., Kimble, W.(2019, June).  The Prevalence of Poly-Substance Use among Psychiatric and Emergency Department Patients in West Virginia. College on Problems of Drug Dependence,. San Antonio, TX.
  4. Mahoney, III, J.J., Winstanley, E., Lander, L.R., Berry, J.H., Marshalek, P.J., Zheng, W., Marton, J., Haut, M.W. (2020, June). Something to Despair: Gender Differences in Adverse Childhood Experiences among Rural Patients. College on Problems of Drug Dependence [virtual meeting due to COVID-19 pandemic].
  5. Mahoney, III, J.J., Haut, M., Hodder, S., Zheng, W., Lander, L., Berry, J., Brandmeir, N., Ranjan, M., Finomore, V., Wang, G., Tomasi, D., Shokri-Kojori, E., Rezai, A. (2021, May). Deep Brain Stimulation of the Nucleus Accumbens/Ventral Capsule for Co-occurring Opioid and Benzodiazepine Use Disorder. 2nd Annual NIH Heal Initiative Investigator Meeting [virtual meeting due to COVID-19 pandemic].
  6. Mahoney, III, J.J., Haut, M., Hodder, S., Zheng, W., Lander, L., Berry, J., Marton, J., Ranjan, M., Finomore, V., Farmer, D., Aklin, W., Wang, G., Tomasi, D., Shokri-Kojori, E., Rezai, A. (2022, April). Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder. 3rd Annual NIH Heal Initiative Investigator Meeting [virtual meeting due to COVID-19 pandemic].
  7. Mahoney, III, J.J., Haut, M., Carpenter, J., Zheng, W., Berry, J., Marton, J., Finomore, V., Rezai, A. (2022, June). Low Intensity Focused Ultrasound Targeting the Nucleus Accumbens as a Potential Adjunctive Treatment for Substance Use Disorder. College on Problems of Drug Dependence, Minneapolis, MN.
  8. Marton, J., Farmer, D., Long, A., Winstanley, E., Finomore, V., Rezai, A., Mahoney, III, J.J. (2022, June). Assessing Changes in Cognitive Functioning in Individuals with Opioid Use Disorder Enrolled in a Residential Treatment Program. College on Problems of Drug Dependence, Minneapolis, MN.

 

 

 

 

Invited Lectures and Oral Presentations

 

*Abbreviated list from 23 invited lectures and oral presentations

 

  1. Mahoney, III, J.J.  (2019, April).  Novel and Innovative Studies on Addiction Treatment. Oral presentation at the Annual Meeting of the WVCTSI. White Sulphur Springs, WV.
  2. Mahoney, III, J.J., Berry, J.H. (2020, June). Rockefeller Neuroscience Institute: Substance Use Disorder Treatment Interventions. Oral presentation for the SAMHSA Region III Harm Reduction Summit [virtual meeting due to COVID-19 pandemic].
  3. Mahoney, III, J.J., Haut, M., Hodder, S., Zheng, W., Lander, L., Berry, J., Brandmeir, N., Ranjan, M., Finomore, V., Wang, G., Tomasi, D., Shokri-Kojori, E., Rezai, A. (2020, June). Deep Brain Stimulation of the Nucleus Accumbens/Ventral Capsule for Co-occurring Opioid and Benzodiazepine Use Disorder. Oral presentation during the Late Breaking Research Session at the annual meeting of the College on Problems of Drug Dependence [virtual meeting due to COVID-19 pandemic].
  4. Mahoney, III, J.J.  (2020, November). Novel and Innovative Studies on Addiction Treatment. Oral presentation at the Rural Drug Addiction Symposium on Substance Use Research [virtual conference due to COVID-19 pandemic].
  5. Mahoney, III, J.J., Rezai, A.R. (2021, February). Neuromodulation for Substance Use Disorders: Invasive and Noninvasive Modalities. Oral presentation at the National Institute on Drug Abuse Intramural Research Program seminar series. Bethesda, MD.
  6. Mahoney, III, J.J. (2021, March). Neuromodulation as an Adjunctive Treatment Strategy for Substance Use Disorders. Oral presentation at the Emerging Addiction Workshop, Columbia University, New York, NY.
  7. Mahoney, III, J.J., Haut, M., Hodder, S., Zheng, W., Lander, L., Berry, J., Brandmeir, N., Ranjan, M., Finomore, V., Rezai, A. (2021, October). Deep Brain Stimulation of the Nucleus Accumbens/Ventral Capsule for Treatment Refractory Substance Use Disorder. Oral presentation during Opioid Awareness Week hosted by Weber State University, Ogden, Utah [virtual conference due to COVID-19 pandemic].
  8. Mahoney, III, J.J. (2021, November). Preliminary Investigation of Low Intensity Focused Ultrasound Applied to the Nucleus Accumbens as a Potential Treatment for Substance Use Disorder: Impact on Substance Craving and Cognition. Oral presentation at the Rural Drug Addiction Symposium on Substance Use Research [virtual conference due to COVID-19 pandemic].
  9. Mahoney, III, J.J. (2022, May). Ensuring that Participant Study-Related Needs Are Met Post-Trial Completion: Responsibilities of the Investigator/Investigative Team. Oral presentation during the BRAIN Neuroethics Working Group (NEWG) workshop on Continuing Trial Responsibilities, National Institute of Health [virtual conference].
  10. Mahoney, III, J.J. (2022, May). Neuromodulation as an Adjunctive Treatment Strategy for Substance Use Disorders. Oral presentation during the Pathway to a Healthier Kentucky Conference hosted by the University of Kentucky Department of Physician Assistant Studies, Lexington, KY.

Research Interests

Research

 

Research Interests

 

My specific areas of research focus includes cognitive sequelae related to substance use as well as the investigation of various forms of neuromodulation, including deep brain stimulation, focused ultrasound, and transcranial magnetic stimulation for the treatment of substance use disorders. My current interests emerged from my previous research work as a Clinical Research Manager at the University of California, Los Angeles and the Baylor College of Medicine where the primary focus of the laboratories was Phase I medication development for stimulant use disorders. During this time, while the primary outcomes of the clinical trials were safety and initial efficacy of the medications, I was able to carve out my own niche that included evaluating whether these compounds impacted cognition as some of these agents had cognitive enhancing properties.

 

Research Topics:

 

  1. Investigating Novel Treatments for Substance Use Disorder
  2. Neuropsychological Sequelae Associated with Substance Use Disorder

 

Research Topics:

  1. Investigating Novel Treatments for Opioid Use Disorder
  2. Neuropsychological Sequelae Associated with Opioid Use Disorder

Patient Care Information

Special Training

  • Fellowship, Clinical Neuropsychology Postdoctoral Fellowship (APPCN Member)
    University of Virginia School of Medicine, 2016
  • Other Speciality Training, Clinical Psychology Internship - Neuropsychology Track
    University of Oklahoma Health Sciences Center, 2014