PO Box 9227
room 211, Erma Byrd Biomedical Research Center (BMRC)
- Curriculum Vitae
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- West Virginia University School of Medicine
- Human Performance - Exercise Physiology
Program 2: Breast Cancer
- BS, Health and Physical Education, The College of New Jersey, 1997
- MS, Exercise Science, Appalachian State University, 2001
- PhD, Exercise Physiology, West Virginia University, 2006
Ten most recent:
IL-15Ralpha deficiency in skeletal muscle alters respiratory function and the proteome of mitochondrial subpopulations independent of changes to the mitochondrial genome.
O'Connell GC, Nichols C, Guo G, Croston TL, Thapa D, Hollander JM, Pistilli EE.
Interleukin-15 directly stimulates pro-oxidative gene expression in skeletal muscle in-vitro via a mechanism that requires interleukin-15 receptor alpha.
O'Connell GC, Pistilli EE.
Biochem Biophys Res Commun. 2015;458(3):614-619.
Muscle-specific deletion of exons 2 and 3 of the IL15RA gene in mice: effects on contractile properties of fast and slow muscles.
O'Connell GC, Guo G, Stricker J, Quinn LS, Ma A, Pistilli EE.
J Appl Physiol (1985). 2015;118(4):437-448.
Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy.
Nader GA, von WF, Liu C, Lindvall J, Gutmann L, Pistilli EE, Gordon PM.
J Appl Physiol (1985). 2014;116(6):693-702.
Aging alters contractile properties and fiber morphology in pigeon skeletal muscle.
Pistilli EE, Alway SE, Hollander JM, Wimsatt JH.
J Comp Physiol B. 2014;184(8):1031-1039.
Non-invasive serial casting to treat persistent toe walking in an 18 month old toddler.
Pistilli EE, Rice T, Pergami P, Mandich MB.
Non-invasive serial casting to treat idiopathic toe walking in an 18-month old child.
Pistilli EE, Rice T, Pergami P, Mandich MB.
FER-1/Dysferlin promotes cholinergic signaling at the neuromuscular junction in C. elegans and mice.
Krajacic P, Pistilli EE, Tanis JE, Khurana TS, Lamitina ST.
Biol Open. 2013;2(11):1245-1252.
Microarray analysis reveals novel features of the muscle aging process in men and women.
Liu D, Sartor MA, Nader GA, Pistilli EE, Tanton L, Lilly C, Gutmann L, IglayReger HB, Visich PS, Hoffman EP, Gordon PM.
J Gerontol A Biol Sci Med Sci. 2013;68(9):1035-1044.
IL-15Ralpha deficiency leads to mitochondrial and myofiber differences in fast mouse muscles.
Pistilli EE, Guo G, Stauber WT.
Research in this laboratory is focused on breast cancer-induced cachexia, defined as the loss of skeletal muscle mass and greater muscle dysfunction that occurs during tumor growth and in response to traditional therapies. There is a specific emphasis on the therapeutic implications for the cytokine interleukin-15. In addition to the effects of IL-15 on lymphocytes, my laboratory has established a direct role of IL-15 in stimulating mitochondrial biogenesis in skeletal muscle. Therefore, experiments in the lab are focused on these dual roles of IL-15 during cancer and include: 1) mechanisms of IL-15 in altering the tumor microenvironment by promoting infiltration of NK cells and CD 8 T cells into mammary tumors; and 2) mechanisms of IL-15 in promoting mitochondrial biogenesis within skeletal muscle as a way to attenuate the muscle fatigue typically experienced in cancer patients. We have established a mouse model of mammary tumor growth, evaluated the lymphocyte populations in the mammary tumor microenvironment, and characterized the alterations in muscle contractile properties. Currently, the lab is evaluating the therapeutic effects of IL-15 in our tumor model using transgenic mice that over-express IL-15 within skeletal muscle and transgenic mice that have muscle-specific knockout of IL15Ralpha. The lab also has established a collaboration with breast surgeons in the WVU Cancer Institute to acquire muscle biopsy samples from breast cancer patients. These biopsy samples will be used for NextGen RNASeq to determine the unique genetic signature of muscle in response to breast cancer. Biopsy samples are being collected from multiple breast tumor subtypes which will allow for identification of molecular markers unique to ER/PR+, Her2+, and triple negative tumors as well as markers common among breast tumors. The long-term goals of the lab are to acquire data on the therapeutic efficacy of IL-15-based therapies that can be translated to human breast cancer patients as well as to identify novel molecular markers in muscle in response to breast cancer.