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- Neurobiology & Anatomy
- Centers for Neuroscience
Program 2: Breast Cancer
- West Virginia University WVU Cancer Institute
- WVU Cancer Institute Research Programs
Ten most recent:
Cerebral response to peripheral challenge with a viral mimetic.
Neurochem Res. 2016; 41(1-2): 144-155.
Peripherally restricted viral challenge elevates extracellular glutamate and enhances synaptic transmission in the hippocampus.
Hunsberger HC, Wang D, Petrisko TJ, Alhowail A, Setti SE, Suppiramaniam V, Konat GW, Reed MN.
J Neurochem. 2016; 138(2): 307-316.
Analysis of extinction acquisition to attenuated tones in prenatally stressed and non-stressed offspring following auditory fear conditioning.
Salm AK, Lally BE, Borysiewicz E, Fil D, Konat GW.
Physiol Behav. 2015; 139: 157-166.
TLR3 ligation protects human astrocytes against oxidative stress.
Borysiewicz E, Doppalapudi S, Kirschman LT, Konat GW.
J Neuroimmunol. 2013;255(1-2):54-59.
A broad upregulation of cerebral chemokine genes by peripherally-generated inflammatory mediators.
Fil D, Borysiewicz E, Konat GW.
Metab Brain Dis. 2011;26(1):49-59.
Peripheral immune challenge with dsRNA enhances kainic acid-induced status epilepticus.
Kirschman LT, Borysiewicz E, Fil D, Konat GW.
Metab Brain Dis. 2011;26(1):91-93.
Peripheral immune challenge with viral mimic during early postnatal period robustly enhances anxiety-like behavior in young adult rats.
Konat GW, Lally BE, Toth AA, Salm AK.
Metab Brain Dis. 2011;26(3):237-240.
Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levels.
Darwish DS, Wang DS, Konat GW, Schreurs BG.
Behav Neurosci. 2010;124(1):115-123.
Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis.
Dod HS, Bhardwaj R, Sajja V, Weidner G, Hobbs GR, Konat GW, Manivannan S, Gharib W, Warden BE, Nanda NC, Beto RJ, Ornish D, Jain AC.
Am J Cardiol. 2010;105(3):362-367.
Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes.
Borysiewicz E, Fil D, Dlaboga D, O'Donnell JM, Konat GW.
Metab Brain Dis. 2009;24(3):481-491.
My research interests are primarily focused on innate immunity of the brain. In particular, the research objective of my laboratory is to elucidate mechanisms by which inflammatory episodes in the periphery elicit inflammatory response in the brain and alter its function.
Metabolic Brain Disease (Editor-in-Chief)
Neurobiology and Anatomy; Center for Basic and Translational Stroke Research
The immune system and the brain maintain intricate communication that plays an important role in both health and disease. For example, epidemiological evidence indicates that peripheral inflammatory conditions are comorbid factors in epilepsy. The putative mechanisms entail pathways by which inflammatory signals are relayed to the brain and lower seizure threshold. However, these pathways have not been defined. We have developed a mouse model to study the effect of viral infections on seizure propensity. In this model, peripheral inflammation is induced by peritoneal injection of dsRNA, a viral mimic. This inflammatory challenge renders the brain hypersusceptible to kainic acid-induced seizures as seen from increased severity and prolonged duration of status epilepticus. Our experimental paradigm provides a valuable heuristic model for unveiling mechanisms by which peripheral inflammatory signals are conveyed to the brain and affect its function.